Serum Interleukin-36 in Pityriasis Rosea: A Potential Biomarker for Disease Severity.

Objective: Pityriasis rosea (PR) is a self-limiting acute rash with unclear etiology and pathogenesis. The cytokine profile of PR is an infrequently investigated field of research. The aim of this study was to assess the level of IL-36 in sera of patients with PR and its possible interrelation with disease severity.

Serum Fetuin-A: A Novel Potential Link Between Post-adolescent Acne and Insulin Resistance.

Background: Post-adolescent acne is acne in patients aged older than 25 years. It is more common in women, suggesting an underlying hormonal imbalance. It has been postulated that insulin resistance (IR) may play a role in pathogenesis.

COVID-19 in children ranging from asymptomatic to a multi-system inflammatory disease: A single-center study.

Objectives: To identify clinical and laboratory characteristics of the Saudi children with confirmed COVID-19.

Methods: Eighty-eight children (0-14 years) with COVID-19 who were admitted to Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia from April to June 2020 were recruited.

Results: Mean age was 5.

Serum Levels of Eosinophil-derived Neurotoxin in Patients with Chronic Urticaria.

Despite the many theories that have been published over the years, the exact pathology of chronic urticaria (CU) is still largely unknown. Eosinophils have been implicated in many cutaneous disorders-serving as major effector cells, inducing tissue damage and dysfunction by releasing granule proteins, including eosinophil cationic protein (ECP), inflammatory lipid mediators, mitochondrial DNA, and eosinophil-derived neurotoxin (EDN), which is relatively neutral with some cytotoxic properties. We sought to evaluate serum levels of EDN in patients with CU and to correlate their levels with the severity of their disease.

Relation between GSTP1 polymorphism and oxidative stress in patients with hepatocellular carcinoma.

Background: Glutathione can reduce the oxidative stress by converting the unstable to stable molecules and its status in hepatocellular carcinoma (HCC) is correlated with tumor growth and metastasis. Glutathione S-transferase Pi (GSTP1) is reported to detoxify the xenobiotic substrates by catalyzing their conjugation to reduced glutathione (GSH) and its over-expression was demonstrated in the early stages of HCC, while loss of GSTP1 has been suggested to increase the risk of deoxyribonucleic acid (DNA) damage and mutation. The aim of this study is to assess the relationship of GSTP1 polymorphism Ile105Val (rs1695 A > G) with HCC risk, and to investigate the oxidative stress status of HCC patients by measuring the antioxidant glutathione (GSH) levels.