Dentogingival display through lip border movements: Report of the Committee on Research in Fixed Prosthodontics of the American Academy of Fixed Prosthodontics.

Statement Of Problem: Dentists strive to create natural looking teeth for their patients. However, much of the research on esthetic dentistry has used artificial and computer-generated images to establish esthetic norms. Altered images are helpful in determining personal preferences but may be misleading for natural norms.

Dentin Cross-linking Effect of Carbodiimide After 5 Years.

Carbodiimide (EDC)-based dentin primers preserve hybrid layer (HL) integrity. However, aging >1 y has not been investigated. The present study examined whether the cross-linking effect of EDC was reflected in dentin bond strength, endogenous enzymatic activity, and the chemical profile of the HL after 5-y aging in artificial saliva.

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management.

The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow.

A novel dentin bonding scheme based on extrafibrillar demineralization combined with covalent adhesion using a dry-bonding technique.

Dentin bonding is a dynamic process that involves the penetration of adhesive resin monomers into the extrafibrillar and intrafibrillar demineralized collagen matrix using a wet-bonding technique. However, adhesive resin monomers lack the capacity to infiltrate the intrafibrillar space, and the excess water that is introduced by the wet-bonding technique remains at the bonding interface. This imperfectly bonded interface is inclined to hydrolytic degradation, severely jeopardizing the longevity of bonded clinical restorations.

Effects of pre-mixed hydraulic calcium silicate putties on osteogenic differentiation of human dental pulp stem cells in vitro.

Objectives: An experimental tricalcium silicate and dicalcium silicate-containing endodontic putty has been designed to overcome the issue of reduced shelf life after exposure to atmospheric moisture during repeated opening of the container for clinical retrieval. The present study examined the effects of this experimental hydraulic putty on the mineralogenic characteristics of osteogenic lineage-committed human dental pulp stem cells (hDPSCs), by comparing the cellular responses with a commercially available putty (EndoSequence BC RRM Putty).

Methods: The osteogenic potential of hDPSCs that had been exposed to the putties was examined using quantitative reverse-transcription polymerase chain reaction for osteogenic gene expressions and western blot for osteogenic protein expressions.

Bonding to dentin using an experimental zirconium oxynitrate etchant.

Objective: To investigate, by means of microtensile bond strength test (μTBS), nanoleakage expression analysis (NL), gelatin zymography and in situ zymography, the effects of an experimental metal salt-based zirconium oxynitrate etchant [ZrO(NO),] - ZON with two simplified adhesives on long-term bond strength and endogenous enzymatic activities.

Methods: Middle/deep coronal dentin surfaces (N = 32) were conditioned either with a traditional 37 % HPO etchant (TE) or with ZON. Further, a single-component etch-and-rinse adhesive (EF) or a universal adhesive (AU) were applied and μTBS and NL tests were performed.

Stone verification device for verifying the definitive cast of an implant-supported restoration: A dental technique.

To reduce the risk of implant and prosthetic complications, implant-supported prostheses should be passive. A verification device is used to verify the abutment analog position on the definitive cast, and hence its accuracy. This article describes the fabrication of a Type IV stone implant verification device for verifying the accuracy of the definitive cast.

shifts macrophage polarization toward M1-like phenotype with an altered cytokine profile.

: The macrophage is an innate immune defense cell involved in pathogen recognition and clearance. : In view of the diversity of the macrophage phenotype and function, the present study investigated how infection affects the differentiation, phenotype and cytokine profile of macrophages. : Murine bone marrow-derived stem cells were co-cultured with before and after differentiation.

Curcumin suppresses cell growth and attenuates fluoride-mediated Caspase-3 activation in ameloblast-like LS8 cells.

The trace element fluoride can be beneficial for oral health by preventing dental caries. However, fluoride is also known as an environmental pollutant. Fluoride pollution can lead to fluoride over-ingestion and can cause health issues, including dental fluorosis.

Local delivery of simvastatin maintains tooth anchorage during mechanical tooth moving via anti-inflammation property and AMPK/MAPK/NF-kB inhibition.

Simvastatin (SMV) could increase tooth anchorage during orthodontic tooth movement (OTM). However, previous studies on its bone-specific anabolic and anti-inflammation properties were based on static in vitro and in vivo conditions. AMPK is a stress-activated kinase that protects tissue against serious damage from overloading inflammation.

Clinical outcomes of implant-retained mandibular overdentures using the bar and magnetic attachment systems: an up to 5-year retrospective study.

Background: Implant-retained mandibular overdentures (IODs) represent an effective and reliable treatment modality for edentulous patients. The present retrospective study compared the clinical outcomes of IODs using bar attachment (BA) system with those using magnetic attachment (MA) system after functioning for up to 5 years.

Methods: Human subjects treated with IODs between 01-01-2010 and 12-31-2014 were identified from patient records.