337 results match your criteria: "The Dental College of Georgia[Affiliation]"

Article Synopsis
  • Diabetic retinopathy (DR) is a major cause of blindness, and understanding its mechanisms is crucial for creating better treatments.
  • In this study, human retinal endothelial cells (HRECs) were treated with 15-HETE or D-glucose, leading to significant changes in miRNA expression, with 15-HETE affecting 640 miRNAs and glucose affecting 429 miRNAs.
  • The research highlights the role of the 12/15 lipoxygenase pathway and suggests that targeting these pathways might be beneficial in treating DR.
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Efficacy of root filling removal from aged, minimally instrumented mandibular molars using a retreatment system combination.

J Dent

January 2025

Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada. Electronic address:

Objective: This study evaluated the efficacy of the ProTaper Universal Retreatment system (PTUR) and XP-endo Finisher R instrument (XPFR) in removing 64-month-old root filling material from minimally-instrumented mandibular molar canals.

Methods: Forty-eight root canals with Vertucci type II or IV configurations from 30 mandibular molars were instrumented to size 20/0.04 taper using Vortex Blue NiTi rotary instruments and irrigated with the GentleWave system.

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Advanced Adhesive Approach to Support a Minimally Invasive Full Mouth Rehabilitation.

J Esthet Restor Dent

November 2024

Division of Prosthodontics, Department of Advanced Oral Sciences and Therapeutics, School of Dentistry, University of Maryland, Baltimore, Maryland, USA.

Objective: Patients who exhibit severe loss of tooth structure are challenging to rehabilitate. Conventional treatment of these patients may require adjunctive procedures of surgical crown lengthening, elective endodontic therapy and placement of posts and cores to retain full coverage crowns as part of a full mouth rehabilitation. Minimally invasive approaches to treatment of these patients provides opportunity to conserve tooth structure and to reduce adjunctive procedures by using an advanced adhesive approach to retain all ceramic partial coverage restorations as part of a full mouth rehabilitation.

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Periosteum-bone inspired hierarchical scaffold with endogenous piezoelectricity for neuro-vascularized bone regeneration.

Bioact Mater

February 2025

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China.

The development of scaffolds for repairing critical-sized bone defects heavily relies on establishing a neuro-vascularized network for proper penetration of nerves and blood vessels. Despite significant advancements in using artificial bone-like scaffolds infused with various agents, challenges remain. Natural bone tissue consists of a porous bone matrix surrounded by a neuro-vascularized periosteum, with unique piezoelectric properties essential for bone growth.

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Effect of Electrical Stimulation of Lingual Nerve on Xerostomia: A Randomized Controlled Trial.

JDR Clin Trans Res

October 2024

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Introduction: Xerostomia is a subjective sensation of dry mouth affecting millions of people worldwide. Current management has limitations, often causing side effects. This study aims to investigate whether electrical stimulation of the lingual nerve could offer effective relief for xerostomia sufferers.

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Effectiveness of pulpotomy in managing carious exposure in mature permanent teeth: A systematic review and meta-analysis.

J Dent

November 2024

Hospital of Stomatology, Sun Yat-sen University, Guangzhou, PR China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, PR China. Electronic address:

Objectives: This quantitative systematic review evaluated whether pulpotomy performed with hydraulic calcium silicate cements may be used as an alternative to root canal treatment (RCT) in mature permanent teeth with carious pulp exposure.

Data Sources: A comprehensive search was conducted in PubMed, Web of Science, Scopus, and the Cochrane Library. No language restrictions were applied.

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Background: Limited treatment options exist for damaged nerves and despite impressive advances in tissue engineering, scientists and clinicians have yet to fully replicate nerve development and recruitment. Innervation is a critical feature for normal organ function. While most organs are innervated prior to birth, a rare example of postnatal nerve recruitment occurs in the natural development of secondary teeth during adolescence.

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Mussel-inspired bifunctional coating for long-term stability of oral implants.

Acta Biomater

October 2024

School/Hospital of Stomatology, Lanzhou University, China; Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing of Gansu Province, Lanzhou, 730000, Gansu Province, China. Electronic address:

Peri-implantitis and osseointegration failure present considerable challenges to the prolonged stability of oral implants. To address these issues, there is an escalating demand for a resilient implant surface coating that seamlessly integrates antimicrobial features to combat bacteria-induced peri‑implantitis, and osteogenic properties to promote bone formation. In the present study, a bio-inspired poly(amidoamine) dendrimer (DA-PAMAM-NH) is synthesized by utilizing a mussel protein (DA) known for its strong adherence to various materials.

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A novel simplified method for assessing crystal length and crystalline content in dental ceramics.

Microsc Res Tech

January 2025

Department of Occlusion, Fixed Prosthodontics, and Dental Materials, Federal University of Uberlândia, School of Dentistry, Uberlândia, Minas Gerais, Brazil.

The purpose of this study was to introduce a novel and simple method of evaluating the crystal length and crystalline content of lithium disilicate dental ceramics using images obtained from scanning electron microscopy (SEM) and analyzed with ImageJ (NIH) processing software. Three evaluators with varying experience levels assessed the average crystal length and percentage of crystalline content in four commercial lithium disilicate reinforced glass ceramic materials: IPS e.max (Ivoclar Vivadent), Rosetta SM (Hass), T-Lithium (Talmax), and IRIS CAD (Tianjin).

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Fluoride Alters Gene Expression via Histone H3K27 Acetylation in Ameloblast-like LS8 Cells.

Int J Mol Sci

September 2024

Department of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA.

Article Synopsis
  • - Fluoride ingestion during tooth development can lead to dental fluorosis, and it activates histone acetyltransferase (HAT), which modifies the protein p53 and contributes to fluoride toxicity in specific mouse cells (LS8).
  • - The study showed that fluoride modifies histone acetylation, altering gene expression in LS8 cells, as evidenced by increased acetylation levels of certain genes and corresponding mRNA expression when treated with fluoride.
  • - This research is the first to highlight that fluoride treatment can lead to epigenetic changes through H3 acetylation, indicating a need for further investigation into how fluoride affects enamel development on a genetic level.
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Influence of Battery Levels in Cordless LED Light-curing Units on Properties of Resin Cement and Glass Fiber Post Retention.

Oper Dent

September 2024

*Luís Henrique Araújo Raposo, DDS, MSc, PhD, associate professor, Department of Occlusion, Fixed Prosthodontics and Dental Materials, School of Dentistry, Federal University of Uberlândia, MG, Brazil.

Purpose: This study aimed to assess the impact of battery levels in single-peak and multi-peak light-curing units (LCUs) on irradiance, and their effects on glass fiber post push-out bond strength to root dentin and the degree of conversion of dual-cure universal resin cement.

Methods And Materials: Sixty bovine roots underwent endodontic treatment and were randomly distributed into 6 groups (n=10), formed by combining two LCUs (single-peak and multipeak) and three battery levels (100%, 50%, and 10%). A spectrophotometer measured irradiance (mW/ cm2) and spectral irradiance (mW/cm2/nm).

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Objective: This article puts forward consensus recommendations from PROSEC North America regarding single indirect restorations made from ceramic and nonmetallic biomaterials in posterior teeth.

Overview: The consensus process involved a multidisciplinary panel and three consensus workshops. A systematic literature review was conducted across five databases to gather evidence.

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This study evaluated the influence of hydrofluoric acid (HF) concentration and thermal cycling on the microshear bond strength (µSBS) of a resin luting agent to IPS e.max® CAD and Rosetta® SM. Ceramic specimens (12.

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Recent advances in the pathogenesis and prevention strategies of dental calculus.

NPJ Biofilms Microbiomes

July 2024

State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.

Article Synopsis
  • * If not removed, calculus can cause serious oral conditions like periodontitis, making it crucial to understand its formation mechanisms for better health protection.
  • * Current treatments mainly alleviate symptoms rather than prevent recurrence, highlighting the need for integrated strategies that target both immediate and long-term management of calculus formation.
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Background: This study aimed to assess the quality of various obturation techniques to fill perforation caused by internal root resorption using Micro-computed Tomography.

Methods: Cone-beam computed tomography images of a maxillary central incisor tooth with perforating internal resorptive defect were used to create a 3D printed model of the affected tooth. The replicas were divided into four groups based on the obturation technique used.

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Objective: This study aimed to evaluate the long-term clinical performance of Giomer and a self-etch adhesive system compared with a nanofilled resin composite and etch-and-rinse adhesive system in Class I and Class II restorations.

Method: The study was designed to be double-blinded with intra-individual control. 48 patients with 54 pairs of cavities (class I or class II) were recruited.

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Design and evaluation of an MMP-9-responsive hydrogel for vital pulp therapy.

J Dent

July 2024

Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada. Electronic address:

Objective: To design and evaluate a matrix metalloproteinase 9 (MMP-9)-responsive hydrogel for vital pulp therapy.

Methods: A peptide linker with optimized sensitivity toward MMP-9 was crosslinked with 4-arm poly (ethylene glycol)-norbornene (PEG-NB) by thiol-norbornene photo-polymerization. This resulted in the formation of a hydrogel network in which the peptide IDR-1002 was incorporated.

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Influence of Varied Silane Commercial Brands and Adhesive Application on Bond Strength and Stability to Lithium Disilicate Glass Ceramic.

Oper Dent

May 2024

*Daniel Sundfeld, DDS, MSc, PhD, adjunct professor, Department of Restorative Dentistry and Prosthodontics, Ingá University Center, Uningá, Maningá, PR, Brazil.

Objectives: This study aimed to evaluate the impact of various commercial silane brands with varied chemical compositions with or without the application of an adhesive layer on the microshear bond strength and durability of a resin luting agent to lithium disilicate glass ceramic.

Methods And Materials: Lithium disilicate glass ceramic discs (EMX, IPS e.max Press, Ivoclar Vivadent) measuring 10 mm in diameter and 3 mm in thickness were fabricated (n=240).

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