39 results match your criteria: "The Danish MS Hospitals[Affiliation]"
Identification of disability status in persons with multiple sclerosis by lower limb neuromuscular function - Emphasis on rate of force development.
Mult Scler Relat Disord
November 2022
Exercise Biology, Department of Public Health, Aarhus University, Denmark; The Danish MS Hospitals, Ry and Haslev, Denmark. Electronic address:
Article Synopsis
- Neurodegeneration in multiple sclerosis (MS) notably affects neuromuscular function, specifically in muscle strength and the ability to rapidly increase muscle force (RFD), which is crucial for physical performance.
- The study involved 99 individuals with MS, categorized by disability level, and 34 healthy controls, comparing their neuromuscular metrics like maximal force and RFD along with physical function tests.
- Results indicated significant deficits in all neuromuscular measures for all MS subgroups when compared to healthy controls, highlighting the impact of MS on both muscle force and activation.
The Case for Light Physical Activity and Brain Health: Every Move Counts.
Neurology
September 2022
From the Vanderbilt Memory & Alzheimer's Center (M.A.G.), Vanderbilt University Medical Center, Nashville, TN; Department of Public Health (L.G.H.), Exercise Biology, Aarhus University, Aarhus, Denmark; and The Danish MS Hospitals in Ry and Haslev (L.G.H.), Haslev, Denmark.
Exercise training and neuroprotection in multiple sclerosis.
Lancet Neurol
August 2022
Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Multimethodological validation of the modified fatigue impact scale in a Danish population of people with Multiple Sclerosis.
Mult Scler Relat Disord
September 2022
The Danish MS Hospitals, Ry & Haslev, Denmark.
Objective: To provide a multimethodological validation of MFIS in compliance with the COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN) guidelines using a Danish population of patients with Multiple Sclerosis (pwMS).
Methods: Factor analytic and multidimensional Rasch analytic methods were applied to investigate the structural validity of MFIS. We employed measurement and bi-factor models to address divergence and convergence.
Vitamin D supplementation and increased dairy protein intake do not affect muscle strength or physical function in healthy 6-8-year-old children: the D-pro randomized trial.
Eur J Nutr
October 2022
Section of Sports Science, Department of Public Health, Aarhus University, Aarhus, Denmark.
Purpose: To investigate separate and combined effects of vitamin D supplementation during the extended winter and increased dairy protein intake on muscle strength and physical function in children, and furthermore to explore potential sex differences.
Methods: In a 2 × 2-factorial, randomized winter trial, 183 healthy, 6-8-year-old children received blinded tablets with 20 µg/day vitamin D or placebo, and substituted 260 g/day dairy with yogurts with high (HP, 10 g protein/100 g) or normal protein content (NP, 3.5 g protein/100 g) for 24 weeks during winter at 55° N.
Implications of lower extremity muscle power and force for walking and fatigability in multiple sclerosis - An exploratory pilot-study.
Clin Biomech (Bristol)
June 2022
Faculty of Physical Education, University of Brasília, Brasília, Brazil; Faculty of Ceilândia, University of Brasília, Brasília, Brazil.
Background: Limitations in physical function are common in Multiple Sclerosis (MS), yet it is neither clear how muscle power implicates physical function and walking-fatigability. This pilot-study aims to investigate (1) deficits in muscle power/force alongside walking in persons with MS; (2) associations between muscle power/force and physical functions and (3) the impact of prolonged walking in muscle power/force.
Methods: 30 relapse-remitting persons with MS and 28 healthy controls performed chair rise and plantar flexion on a force platform before and after 12-minutes of intermittent walking to measure lower extremity muscle power/force.
Objectively assessed physiological, physical, and cognitive function along with patient-reported outcomes during the first 2 years of Alemtuzumab treatment in multiple sclerosis: a prospective observational study.
J Neurol
September 2022
Exercise Biology, Department of Public Health, Aarhus University, Dalgas Avenue 4, Aarhus, Denmark.
Article Synopsis
- The study investigates the effects of Alemtuzumab on various aspects of health in patients with multiple sclerosis (pwMS), focusing on physiological, physical, cognitive functions, and patient-reported outcomes over two years of treatment.* -
- Researchers assessed 17 patients through various tests before and at multiple points during treatment, revealing improvements in short distance walking and cognitive functions like memory and processing speed.* -
- Overall, the findings indicate that Alemtuzumab can enhance certain physical and cognitive abilities while stabilizing other health outcomes in pwMS.*
Investigating the potential disease-modifying and neuroprotective efficacy of exercise therapy early in the disease course of multiple sclerosis: The Early Multiple Sclerosis Exercise Study (EMSES).
Mult Scler
September 2022
Exercise Biology, Department of Public Health, Aarhus University, Aarhus C, Denmark.
Background: Potential supplemental disease-modifying and neuroprotective treatment strategies are warranted in multiple sclerosis (MS). Exercise is a promising non-pharmacological approach, and an uninvestigated 'window of opportunity' exists early in the disease course.
Objective: To investigate the effect of early exercise on relapse rate, global brain atrophy and secondary magnetic resonance imaging (MRI) outcomes.
Physical exercise in multiple sclerosis is not just a symptomatic therapy, it has a disease-modifying effect: Commentary.
Mult Scler
May 2022
Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark/The Danish MS Hospitals, Haslev and Ry, Denmark.
Parkinson's disease and intensive exercise therapy - An updated systematic review and meta-analysis.
Acta Neurol Scand
May 2022
Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.
In 2015, Uhrbrand et al. published the first review on Parkinson´s disease (PD) and exercise entirely based on randomized controlled trials (RCT) applying strict exercise definitions. The present review aimed to update the PD literature by assessing the effects of different intensive exercise modalities: resistance training (RT), endurance training (ET), and other intensive exercise modalities (OITM).
View Article and Find Full Text PDFBackground: Inpatient multidisciplinary rehabilitation (MDR) can improve health-related quality of life (HRQoL) in multiple sclerosis (MS) patients. However, the evidence of a long-term benefit is limited.
Objectives: To investigate the long-term effectiveness of inpatient MDR on HRQoL in MS patients.
Spasticity in adults with cerebral palsy and multiple sclerosis measured by objective clinically applicable technique.
Clin Neurophysiol
September 2018
Institute of Neuroscience, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark; Department of Nutrition, Exercise and Sports and Elsass Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark. Electronic address:
Objective: The present study evaluated ankle stiffness in adults with and without neurological disorders and investigated the accuracy and reproducibility of a clinically applicable method using a dynamometer.
Methods: Measurements were obtained from 8 healthy subjects (age 39.3), 9 subjects with spastic cerebral palsy (CP) (age 39.
Is the impact of fatigue related to walking capacity and perceived ability in persons with multiple sclerosis? A multicenter study.
J Neurol Sci
April 2018
REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.
Background: The relationship between fatigue impact and walking capacity and perceived ability in patients with multiple sclerosis (MS) is inconclusive in the existing literature. A better understanding might guide new treatment avenues for fatigue and/or walking capacity in patients with MS.
Objective: To investigate the relationship between the subjective impact of fatigue and objective walking capacity as well as subjective walking ability in MS patients.
Longer term effectiveness of inpatient multidisciplinary rehabilitation on health-related quality of life in MS patients: a pragmatic randomized controlled trial - The Danish MS Hospitals Rehabilitation Study.
Mult Scler
March 2018
Centre of Health Economics Research (COHERE), Department of Public Health, University of Southern Denmark, Odense, Denmark/Healthcare Outcome Research Center, Royal College of Surgeons in Ireland, Dublin, Ireland.
Background: There is insufficient evidence to support the effectiveness of multidisciplinary rehabilitation on the health-related quality of life (HRQoL) of MS patients.
Objectives: To evaluate the longer term effectiveness of inpatient multidisciplinary rehabilitation on the HRQoL of MS patients.
Methods: The study was a two-hospital, pragmatic, randomized controlled trial with a 6-month follow-up.