Psychometric measurement properties and reference values of the six-spot step test, the six-minute walk test, the 25-foot walk test, and the 12-item multiple sclerosis walking scale in people with multiple sclerosis.

Unlabelled: This review investigated the psychometric properties of the most commonly used short-, long-, complex- and patient-reported walking outcome measures in multiple sclerosis(MS): the timed-25-foot walk test (T25FW), the six-minute walk test (6MWT), the six-spot step-test (SSST), and the 12-item MS walking scale (MSWS-12), along with reported reference data of these tests.

Methods: Based on PubMed and Embase searches, psychometric as well as descriptive data of T25FW, 6MWT, SSST, and MSWS-12 were extracted from studies evaluating persons with MS (pwMS). Descriptive data was also extracted from healthy controls (HC), if reported.

Comprehensive evaluation of accelerometer-based physical activity in persons with multiple sclerosis - The influence of disability status and its impact on walking capacity.

Introduction: Multiple sclerosis has a substantial negative impact on physical activity (PA). However, limited knowledge exists on objectively measured PA levels and types across disability status along with its influence on walking capacity.

Objectives: To (1) determine PA levels/types in persons with MS (pwMS) (overall and across disability status) and in healthy controls (HC), and (2) investigate the association between PA levels/types and walking capacity.

Effects of 12-week power training on bone in mobility-limited older adults: randomised controlled trial.

Unlabelled: This study examines how power training affects estimated bone strength, revealing that females benefit more than males, especially in the upper limbs (radius). These findings highlight the importance of designing sex-specific exercise programs to enhance bone health. Further research is needed to optimize training duration and address site-specific differences.

Exercise-induced heat sensitivity in patients with multiple sclerosis: Definition, prevalence, etiology, and management-A scoping review.

Background: For persons with multiple sclerosis (pwMS), exercise is known to be safe and effective at treating several symptoms and it may even be disease-modifying. However, exercise can trigger heat intolerance, exercise-induced heat sensitivity (EIHS), which may cause some pwMS to refrain from exercise. No review has yet summarized the existing knowledge on EIHS in pwMS.

Five days of bed rest in young and old adults: Retainment of skeletal muscle mass with neuromuscular electrical stimulation.

The consequences of short-term disuse are well known, but effective countermeasures remain elusive. This study investigated the effects of neuromuscular electrical stimulation (NMES) during 5 days of bed rest on retaining lower limb muscle mass and muscle function in healthy young and old participants. One leg received NMES of the quadriceps muscle (3 × 30min/day) (NMES), and the other served as a control (CON).

Study protocol: effects of exercise booster sessions on preservation of exercise-induced adaptations in persons with multiple sclerosis, a multicentre randomised controlled trial-the MS BOOSTER trial.

Introduction: Multiple sclerosis (MS) causes a broad range of symptoms, with physical function being one of the most disabling consequences according to patients themselves. Exercise effectively improves lower extremity physical function. Nonetheless, it is unknown which exercise modality is most effective and it remains challenging to keep persons with MS adhering to exercise over a longer period.

Effects of power training in older patients with multiple sclerosis on neurodegeneration, neuromuscular function, and physical function. A study protocol for the "power training in older multiple sclerosis patients (PoTOMS) randomized control trial.

Introduction: Approximately one-third of all persons with multiple sclerosis (pwMS) are older, i.e., having an age ≥60 years.

Exercise as medicine in Parkinson's disease.

Parkinson's disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor and non-motor consequences. Presently, no pharmacological agents can prevent PD evolution or progression, while pharmacological symptomatic treatments have limited effects in certain domains and cause side effects. Identification of interventions that prevent, slow, halt or mitigate the disease is therefore pivotal.

Effects of walking interventions in persons with multiple sclerosis-A systematic review.

Objective: The aim of the present systematic review was to investigate the effects of voluntary walking interventions in persons with multiple sclerosis (pwMS). For this purpose, we developed a framework to describe the components of walking interventions.

Data Sources: Two databases (MEDLINE/PubMed and EMBASE) were searched in January 2023.

Cardiorespiratory fitness (V̇O) across the adult lifespan in persons with multiple sclerosis and matched healthy controls.

Objectives: Cardiorespiratory fitness (measured as peak oxygen uptake; V̇O) is a well-established health predictor in the general population and in persons with multiple sclerosis (pwMS). We aimed to investigate differences in V̇O between age groups and the prevalence of V̇O impairments across the adult lifespan in pwMS compared to age- and sex-matched healthy controls (HC).

Design: Cross-sectional study.

The MoxFo initiative-Mechanisms of action: Biomarkers in multiple sclerosis exercise studies.

Background: As exercise exerts neurobiological and immunomodulatory effects, it might also act as a disease-modifying intervention in MS. However, a clear mechanistic link between exercise and disease-modifying effects in MS has yet to be established.

Objective: Establish recommendations for future mechanistic exercise studies in MS.

Applicability of the Load-Velocity Relationship to Predict 1-Repetition Maximum in the Half-Squat in High-Level Sprinters.

Purpose: To investigate the indirect measurement of 1-repetition-maximum (1RM) free-weight half-squat in high-level sprinters using the load-velocity relationship.

Methods: Half-squat load and velocity data from 11 elite sprinters were collected in 2 separate testing sessions. Approximately 24 hours prior to the first testing session, sprinters completed a fatiguing high-intensity training session consisting of running intervals, staircase exercises, and body-weight exercises.

Muscle Strength and Power in People With Parkinson Disease: A Systematic Review and Meta-analysis.

Background And Purpose: No studies have synthesized the literature regarding mechanical muscle function (ie, strength, power, rate of force development [RFD]) in people with Parkinson disease (PD). Here, we aimed to expand our understanding of mechanical muscle function in people with PD (PwPD) by systematically reviewing (1) the psychometric properties of isokinetic/isometric dynamometry in PD, (2) the literature comparing mechanical muscle function in PwPD with healthy controls (HC), and (3) reported associations between muscle mechanical muscle function and functional capacity and/or disease severity.

Methods: Systematic literature search in 6 databases.

Torque and Discomfort During Electrically Evoked Muscle Contractions in Healthy Young Adults: Influence of Stimulation Current and Pulse Frequency.

Objective: To investigate (1) how current and pulse frequency of electrical stimulation (ES) as well as contraction mode (isometric, concentric, and eccentric) influence torque output and discomfort and (2) how familiarization by repeated ES sessions influences ratings of perceived discomfort.

Design: An experimental study, 3 sessions.

Setting: A university laboratory.