2 results match your criteria: "The Cleveland Clinic and Foundation[Affiliation]"
Bone acidic glycoprotein-75 delineates the extracellular sites of future bone sialoprotein accumulation and apatite nucleation in osteoblastic cultures.
J Biol Chem
June 2004
Department of Biomedical Engineering and the Orthopaedic Research Center, Lerner Research Institute, The Cleveland Clinic and Foundation, Cleveland, Ohio 44195, USA.
Addition of an organophosphate source to UMR osteoblastic cultures activates a mineralization program in which BSP localizes to extracellular matrix sites where hydroxyapatite crystals are subsequently nucleated. This study identifies for the first time novel extracellular spherical structures, termed biomineralization foci (BMF), containing bone acidic glycoprotein-75 (BAG-75), bone sialoprotein (BSP), and alkaline phosphatase that are the exclusive sites of initial nucleation of hydroxyapatite crystals in the UMR model. Importantly, in the absence of added phosphate, UMR cultures after reaching confluency contain two size populations of morphologically identifiable BMF precursors enriched in BAG-75 (15-25 and 150-250 microm in diameter).
View Article and Find Full Text PDFIntermittent lumbar drainage with functional testing in the diagnosis of normal-pressure hydrocephalus.
Eur J Pediatr Surg
December 2001
Department of Neurosurgery, S-80, The Cleveland Clinic and Foundation, Cleveland, OH 44195, USA.