6 results match your criteria: "The City University of New York (CUNY) Graduate Center[Affiliation]"

A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion.

Neuron

December 2024

Neuroscience Initiative, Advanced Science Research Center, The City University of New York (CUNY) Graduate Center, New York, NY 10031, USA; Graduate Program in Biology, CUNY Graduate Center, New York, NY 10016, USA; Graduate Program in Biochemistry, CUNY Graduate Center, New York, NY 10016, USA. Electronic address:

The brain's primary immune cells, microglia, are a leading causal cell type in Alzheimer's disease (AD). Yet, the mechanisms by which microglia can drive neurodegeneration remain unresolved. Here, we discover that a conserved stress signaling pathway, the integrated stress response (ISR), characterizes a microglia subset with neurodegenerative outcomes.

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Article Synopsis
  • The COVID-19 pandemic has significantly impacted various aspects of human life, focusing on public health management through effective communication and behavior change strategies.
  • A large dataset of 51,404 individuals from 69 countries was created for the ICSMP COVID-19 project to analyze the social and moral psychology related to public health behaviors during the early pandemic phase (April-June 2020).
  • The survey included diverse questions on topics like COVID-19 beliefs, social attitudes, ideologies, health, moral beliefs, personality traits, and demographics, and provides raw and cleaned data along with survey materials and psychometric evaluations.
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Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g.

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Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area.

J Chem Neuroanat

November 2014

School of Mental Health and Neuroscience (MHeNs), Faculty of Health, Medicine and Life Sciences, Maastricht University Medical Center, Maastricht, Netherlands. Electronic address:

Hypoxia has been proposed as a mechanism underlying gene-environment interactions in the neurodevelopmental model of schizophrenia, and hypoxia-inducible factor 1 (HIF-1) could mediate the interactions. In the current study, we analyzed the HIF-1 beta subunit, as formed by aryl hydrocarbon receptor nuclear translocator (ARNT) or ARNT2, in the mouse substantia nigra (SN) and the ventral tegmental area (VTA). We performed immunohistochemical studies of ARNT and ARNT2 in the adult mouse brain, and colocalization analyses, with specific emphasis on dopaminergic cells, i.

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he factor structure of the Transcultural Self-Efficacy Tool (TSET) was analyzed using data from 272 culturally diverse undergraduate nursing students. The TSET is a questionnaire designed to measure students' confidence for performing general transcultural nursing skills among diverse client populations. Using the most recent imputation techniques for missing data, researchers demonstrate how common exploratory factor analysis (CEFA)--(as opposed to principal components analysis)--can (and should be) used in examining the factorial composition of the tool.

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