1 results match your criteria: "The City College of New York (J.M.T.). laura.niklason@yale.edu.[Affiliation]"
New Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx.
Arterioscler Thromb Vasc Biol
September 2016
From the Department of Biomedical Engineering (S.D., T.L., W.W., T.R.K., L.E.N.), Department of Anesthesiology (L.G., S.S., J.L.B., L.E.N.), Department of Surgery (W.W., C.T.T.), Department of Medicine (L.T.), and Department of Pharmacology (T.R.K.), Yale University, New Haven, CT; Howard Hughes Medical Institute, Chevy Chase, MD (S.D., R.J.L.); Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY (A.W., C.C., R.J.L.); Department of Biomedical Engineering, University of Connecticut, Storrs (D.S.); and Department of Biomedical Engineering, The City College of New York (J.M.T.).
Objective: It is widely accepted that the presence of a glycosaminoglycan-rich glycocalyx is essential for endothelialized vasculature health; in fact, a damaged or impaired glycocalyx has been demonstrated in many vascular diseases. Currently, there are no methods that characterize glycocalyx functionality, thus limiting investigators' ability to assess the role of the glycocalyx in vascular health.
Approach And Results: We have developed novel, easy-to-use, in vitro assays that directly quantify live endothelialized surface's functional heparin weights and their anticoagulant capacity to inactivate Factor Xa and thrombin.