Bias-corrected CMIP6 global dataset for dynamical downscaling of the historical and future climate (1979-2100).

Dynamical downscaling is an important approach to obtaining fine-scale weather and climate information. However, dynamical downscaling simulations are often degraded by biases in the large-scale forcing itself. We constructed a bias-corrected global dataset based on 18 models from the Coupled Model Intercomparison Project Phase 6 (CMIP6) and the European Centre for Medium-Range Weather Forecasts Reanalysis 5 (ERA5) dataset.

Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways.

Cyanidin is an anthocyanin widely distributed in food diet with novel antioxidant activity. Herein, we investigated the protective effects of cyanidin on HK-2 proximal tubular cells against cisplatin-induced apoptosis and elucidated the underlying mechanisms. The results showed that cisplatin-induced apoptosis in HK-2 cells was significantly attenuated by cyanidin.

The effect of hyaluronan on osteoblast proliferation and differentiation in rat calvarial-derived cell cultures.

Hyaluronan (or hyaluronic acid, HA) is an essential component of extracellular matrices. It interacts with other macromolecules and plays a predominant role in tissue morphogenesis, cell migration, differentiation, and adhesion. The cell signaling functions of HA are mediated through the CD-44 receptor and are dependent upon the molecular weight of the polymer.

A qualitative study of the experiences of a group of Hong Kong Chinese women diagnosed with postnatal depression.

Aim Of The Study: To examine the lived experiences of a group of Hong Kong Chinese women diagnosed with postnatal depression.

Background: Postnatal depression affects approximately 1 in 10 childbearing women in Hong Kong. However, most studies of postnatal depression have been carried out in Western societies and no qualitative research was found describing the experience of Hong Kong Chinese mothers with postnatal depression.

Use of ammonium halides as co-matrices for matrix-assisted laser desorption/ionization studies of oligonucleotides.

Four ammonium salts, NH4F, NH4Cl, NH4Br and NH4I were tested as co-matrices for the matrix-assisted laser desorption/ionization (MALDI) analysis of a number of DNA homopolymers, including phosphorylated d(T)8, d(A)4, d(C)4 and non-phosphorylated d(G)4, using 2-amino-5-nitropyridine (ANP) matrix. In the present study, all the ammonium halides displayed significant enhancement effects on the signal intensities of the intact molecular ions of the DNA homopolymers. Among the halides used, NH4F was found to exhibit the greatest enhancement effects.