Transepithelial phototherapeutic keratectomy for post-traumatic recurrent corneal erosions.

Purpose: To evaluate the outcomes of transepithelial phototherapeutic keratectomy (transepithelial PTK) for treatment of posttraumatic recurrent corneal erosions.

Methods: Twenty-four eyes of 22 patients with posttraumatic recurrent corneal erosions who were treated with transepithelial PTK from April 2018 to July 2020 were included in this retrospective study. The rates of recurrent erosions and complications were evaluated during the follow-up after surgery.

Effects of a hospital-based leisure activities programme on nurses' stress, self-perceived anxiety and depression: A mixed methods study.

Aims: To determine the effects of a hospital-based leisure activities programme on nurses' stress, self-perceived anxiety and depression.

Background: Nursing work in clinical settings is highly stressful and may result in an increase in nurses' turnover rate, which threatens the quality of nursing care and patient safety.

Methods: We used a mixed methods design and a three-month intervention (January to April, 2019) involving a convenience sample of 176 nurses working at a Chinese tertiary hospital.

Vacancy-defect modulated pathway of photoreduction of CO on single atomically thin AgInPS sheets into olefiant gas.

Artificial photosynthesis, light-driving CO conversion into hydrocarbon fuels, is a promising strategy to synchronously overcome global warming and energy-supply issues. The quaternary AgInPS atomic layer with the thickness of ~ 0.70 nm were successfully synthesized through facile ultrasonic exfoliation of the corresponding bulk crystal.

Disease gene prediction with privileged information and heteroscedastic dropout.

Motivation: Recently, machine learning models have achieved tremendous success in prioritizing candidate genes for genetic diseases. These models are able to accurately quantify the similarity among disease and genes based on the intuition that similar genes are more likely to be associated with similar diseases. However, the genetic features these methods rely on are often hard to collect due to high experimental cost and various other technical limitations.

The politics of kitchen work: Co-production of a retired man's "hegemonic masculinity" during the COVID-19 quarantine.

This article documents the reconstructed domestic masculinity of a retired Chinese man during the COVID-19 quarantine period in China. It is based on participant observation of the man and his family as a case study. It demonstrates how the man turns kitchen work into a "masculine" job, and uses it as a contested terrain for constructing hegemonic masculinity by adopting scientific discourse explicitly and traditional patriarchal discourse implicitly.

Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity.

Triple-negative breast cancer (TNBC) is the most challenging subtype of breast cancer. Various endeavor has been made to explore the molecular biology basis of TNBC. Herein, we reported a novel function of factor Kinectin 1 (KTN1) as a carcinogenic promoter in TNBC.

Construction of evaluation indexes of nursing students' quality and safety competencies: A Delphi study in China.

Background: Providing quality and safe nursing care is considered the cornerstone of the healthcare system globally. However, there are no comprehensive evaluation indicators of nursing students' quality and safety competencies in China.

Aim: To develop the evaluation indicators and achieve experts' consensus on bachelor nursing students' quality and safety competencies at their graduation.

Job Stress, Psychological Capital, Perceived Social Support, and Occupational Burnout Among Hospital Nurses.

Purpose: To determine the structural relationships among nurses' occupational burnout, job stress, psychological capital, and perceived support from society.

Design: A cross-sectional design was performed to collect data from 766 registered nurses in three general tertiary Class A hospitals from March to August 2018.

Methods: Structural equation modeling was performed to examine the proposed model.

Infectious keratitis after transepithelial photorefractive keratectomy: A case report.

Transepithelial photorefractive keratectomy (tPRK) promotes faster re-epithelialization which in turn can reduce the risk of infectious keratitis in the postoperative period. We present a case of a 22-year-old man with infectious keratitis in his left eye 8 days after an uneventful bilateral tPRK. A 2 mm × 5 mm anterior stromal area of corneal infiltration with a same sized overlying epithelial defect was noted at the time of presentation.

Selective loss of 5hmC promotes neurodegeneration in the mouse model of Alzheimer's disease.

5-hydroxymethylcytosine (5hmC) is an intermediate stage of DNA de-methylation. Its location in the genome also serves as an important regulatory signal for many biological processes and its levels change significantly with the etiology of Alzheimer's disease (AD). In keeping with this relationship, the TET family of enzymes which convert 5-methylcytosine (5mC) to 5hmC are responsive to the presence of Aβ.

Correction to: A systematic review and meta-analysis of couple-based intervention on sexuality and the quality of life of cancer patients and their partners.

Sentence incorrect.

Regulation of the Circadian Clock by the Spliceosome Component PRP5.

Increasing evidence has pointed to the connection between pre-mRNA splicing and the circadian clock; however, the underlying mechanisms of this connection remain largely elusive. In the filamentous fungus , the core circadian clock elements comprise White Collar 1 (WC-1), WC-2 and FREQUENCY (FRQ), which form a negative feedback loop to control the circadian rhythms of gene expression and physiological processes. Previously, we have shown that in , the pre-mRNA splicing factors Pre-mRNA-processing ATP-dependent RNA helicase 5 (PRP5), protein arginine methyl transferase 5 (PRMT5) and snRNA gene are involved in the regulation of splicing of transcripts, which encode the negative component of the circadian clock system.

Cervical cerclage in twin pregnancy.

Cervical cerclage in women with twin pregnancy is not routinely indicated but appears to be beneficial in subjects with a history of preterm birth or very short cervix or dilated cervix. There is a paucity of literature data regarding transabdominal or laparoscopic cervical cerclage (LCC) in twin pregnancy. It is uncertain whether LCC is more effective than transvaginal cerclage.

Nutritional interventions to prevent and treat frailty.

Purpose Of Review: Frailty is a multidimensional condition common in older adults, where reduced resiliency leads to adverse outcomes. It has strong links with malnutrition and sarcopenia, mostly through muscle health. This review explores the links between nutrition and frailty from different perspectives.

Autotaxin/lysophosphatidic acid signaling mediates obesity-related cardiomyopathy in mice and human subjects.

Obesity is associated with increased cardiovascular morbidity and mortality, but the direct signals to initiate or exaggerate cardiomyopathy remain largely unknown. Present study aims to explore the pathophysiological role of autotaxin/lysophosphatidic acid (LPA) in the process of cardiomyopathy during obesity. Through utilizing mouse model and clinical samples, present study investigates the therapeutic benefits of autotaxin inhibitor and clinical correlation to obesity-related cardiomyopathy.

Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys.

Context: The scarcity of cross-national reports and the changes in Diagnostic and Statistical Manual version 5 (DSM-5) regarding panic disorder (PD) and panic attacks (PAs) call for new epidemiological data on PD and PAs and its subtypes in the general population.

Objective: To present representative data about the cross-national epidemiology of PD and PAs in accordance with DSM-5 definitions.

Design And Setting: Nationally representative cross-sectional surveys using the World Health Organization Composite International Diagnostic Interview version 3.

CRISPR/Cas9 Technology Targeting Fas Gene Protects Mice From Concanavalin-A Induced Fulminant Hepatic Failure.

Fulminant hepatic failure is a life-threatening disease which occurs in patients without preexisting liver disease. Nowadays, there is no ideal therapeutic tool in the treatment of fulminant hepatic failure. Recent studies suggested that a novel technology termed CRISPR/Cas9 may be a promising approach for the treatment of fulminant hepatic failure.

Cancer survival analysis using semi-supervised learning method based on Cox and AFT models with L1/2 regularization.

Background: One of the most important objectives of the clinical cancer research is to diagnose cancer more accurately based on the patients' gene expression profiles. Both Cox proportional hazards model (Cox) and accelerated failure time model (AFT) have been widely adopted to the high risk and low risk classification or survival time prediction for the patients' clinical treatment. Nevertheless, two main dilemmas limit the accuracy of these prediction methods.

Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury.

Autophagic (type II) cell death has been suggested to play pathogenetic roles in cerebral ischemia. Growth arrest and DNA damage response 45b (Gadd45b) has been shown to protect against rat brain ischemia injury through inhibiting apoptosis. However, the relationship between Gadd45b and autophagy in cerebral ischemia/reperfusion (I/R) injury remains uncertain.

Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells.

Background: Growth arrest and DNA-damage inducible protein 45 beta (Gadd45b) is serving as a neuronal activity sensor. Brain ischemia induces the expression of Gadd45b, which stimulates recovery after stroke and may play a protective role in cerebral ischemia. However, little is known of the molecular mechanisms of how Gadd45b expression regulated and the down-stream targets in brain ischemia.

Prognostic value of circulating tumor cells and disseminated tumor cells in patients with ovarian cancer: a systematic review and meta-analysis.

Recent studies have shown diagnostic and prognostic values of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in various cancers, including ovarian cancer. We aimed to evaluate the association of CTCs and/or DTCs with the clinical outcomes of ovarian cancer. Clinical studies of CTCs/DTCs of ovarian cancer were included for systematic review and meta-analysis.

Flexure-based Roll-to-roll Platform: A Practical Solution for Realizing Large-area Microcontact Printing.

A continuous roll-to-roll microcontact printing (MCP) platform promises large-area nanoscale patterning with significantly improved throughput and a great variety of applications, e.g. precision patterning of metals, bio-molecules, colloidal nanocrystals, etc.

MRI-based morphological evidence of spinal cord tethering predicts curve progression in adolescent idiopathic scoliosis.

Background Context: Existing prognostic factors for adolescent idiopathic scoliosis (AIS) patients have focused mainly on curve, maturity, and bone-related factors. Previous studies have shown significant associations between curve severity and morphological evidences of relative shorter spinal cord tethering in AIS, and increased prevalence of abnormal somatosensory cortical-evoked potentials and low-lying cerebellar tonsil in severe AIS. Earlier evidence suggests that there might be neural morphological predictors for curve progression.