53 results match your criteria: "The Children's Hospital at Westmead and The University of Sydney[Affiliation]"
Introduction: We analysed Australian Immunisation Register (AIR) data as at 3 April 2022 for children, adolescents and adults for the calendar year 2021, with data on trends from previous years also presented.
Children: 'Fully vaccinated' coverage in Australian children in 2021 was 0.6-0.
A Global Perspective on PDA Management in the Extremely Premature: Shifting Trend Toward Transcatheter Closure.
J Soc Cardiovasc Angiogr Interv
May 2023
UC Davis Medical Center, Sacramento, California.
Patent ductus arteriosus (PDA) is a frequently encountered defect in infants born extremely premature (≤26 weeks' gestation). Historically, closure of the PDA was performed using cyclooxygenase inhibitor medications or by surgical ligations. However, the benefits of PDA closure using these therapies have never been demonstrated, albeit studies have previously not focused on the extremely premature infants.
View Article and Find Full Text PDFMyostatin and follistatin as monitoring and prognostic biomarkers in dysferlinopathy.
Neuromuscul Disord
February 2023
The John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. Electronic address:
Myostatin is a myokine which acts upon skeletal muscle to inhibit growth and regeneration. Myostatin is endogenously antagonised by follistatin. This study assessed serum myostatin and follistatin concentrations as monitoring or prognostic biomarkers in dysferlinopathy, an autosomal recessively inherited muscular dystrophy.
View Article and Find Full Text PDFAnnual immunisation coverage report 2020.
Commun Dis Intell (2018)
September 2022
National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead and The University of Sydney.
We analysed Australian Immunisation Register (AIR) data as at 31 March 2021 for children, adolescents and adults. This is the first time that adolescent and adult coverage data from the AIR have been included in our annual coverage report.
View Article and Find Full Text PDFWater T2 could predict functional decline in patients with dysferlinopathy.
J Cachexia Sarcopenia Muscle
December 2022
The John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Background: Water T2 (T2 ) mapping is increasingly being used in muscular dystrophies to assess active muscle damage. It has been suggested as a surrogate outcome measure for clinical trials. Here, we investigated the prognostic utility of T2 to identify changes in muscle function over time in limb girdle muscular dystrophies.
View Article and Find Full Text PDFRisdiplam-Treated Infants with Type 1 Spinal Muscular Atrophy versus Historical Controls.
N Engl J Med
July 2021
From the Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston (B.T.D.); the Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (R.M., G.B.), and the Center of Translational and Experimental Myology, IRCCS Istituto Giannina Gaslini, Genoa (C.B.) - both in Italy; the Department of Developmental Neurology, Medical University of Gdańsk, Gdańsk, Poland (M.M.-B.); the Paediatric Gait Analysis Service of New South Wales, the Children's Hospital at Westmead and the University of Sydney, Sydney (K.R.); the Department of Pediatrics, Peking University First Hospital, Beijing (H.X.), and Children's Hospital of Fudan University, Shanghai (Y.W.) - both in China; the Department of Neurology, Faculdade de Medicina, Universidade de São Paulo, São Paulo (E.Z.); the Dubowitz Neuromuscular Centre, National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, and Great Ormond Street Hospital for Children NHS Foundation Trust, London (G.B.), Roche Products, Welwyn Garden City (M.E.-K.), and the Muscular Dystrophy UK Oxford Neuromuscular Centre, the Department of Paediatrics, University of Oxford, Oxford (L.S.) - all in the United Kingdom; Russian Children Neuromuscular Center, Veltischev Clinical Pediatric Research Institute, Pirogov Russian National Research Medical University, Moscow (D.V.); Pharma Development, Safety (M.G.), Product Development Medical Affairs - Neuroscience and Rare Disease (K.G., P.F.), and Pharma Development Neurology (R.S.S.), F. Hoffmann-La Roche, and Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel (O.K., H.K.) - both in Basel, Switzerland; the Division of Child Neurology, Centre de Références des Maladies Neuromusculaires, the Department of Pediatrics, University Hospital Liege, University of Liege, Liege, Belgium (L.S.); and I-Motion, Institut de Myologie, Assistance Publique Hôpitaux de Paris, Hôpital Armand Trousseau, Paris (L.S.).
Article Synopsis
- Type 1 spinal muscular atrophy (SMA) is a severe neuromuscular condition that affects infants, characterized by an inability to sit unsupported and low levels of survival of motor neuron (SMN) protein.
- The study tested risdiplam, a medication that enhances SMN protein levels, in infants aged 1 to 7 months and evaluated its effectiveness and safety over 12 months compared to historical controls.
- Results showed that 29% of infants could sit without support after treatment and significant improvements were seen in key motor function assessments versus historical data.
Facemask against viral respiratory infections among Hajj pilgrims: A challenging cluster-randomized trial.
PLoS One
December 2020
National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead and The University of Sydney, Sydney, New South Wales, Australia.
Background: In this large-scale cluster-randomized controlled trial (cRCT) we sought to assess the effectiveness of facemasks against viral respiratory infections.
Methods And Results: Over three consecutive Hajj seasons (2013, 2014, 2015) pilgrims' tents in Makkah were allocated to 'facemask' or 'no facemask' group. Fifty facemasks were offered to participants in intervention tents, to be worn over four days, and none were offered to participants in control tents.
Deficits in all aspects of social competence identified in children who have undergone epilepsy surgery.
Epilepsy Behav
November 2020
School of Psychology, The University of Sydney, NSW 2006, Australia. Electronic address:
Research on social competence of children who undergo epilepsy surgery is limited. This cross-sectional study aimed to determine the frequency and pattern of impairments in social competence (domains: social skills, social adjustment, and social performance) in a cohort of children who underwent surgery for intractable epilepsy at a single epilepsy surgical center. In addition, we explored the relationships between social competence with epilepsy variables, surgical variables, and seizure outcomes.
View Article and Find Full Text PDFThe upcoming UN general assembly resolution on tuberculosis must also benefit children.
Lancet Glob Health
May 2018
The Indus Hospital, Karachi, Sindh, Pakistan.
Reproducibility of Cardiac Magnetic Resonance Imaging (CMRI)-Derived Right Ventricular Parameters in Repaired Tetralogy of Fallot (ToF).
Heart Lung Circ
March 2018
Cardiology and Cardiac MR, Royal Prince Alfred Hospital, The Heart Centre for Children, The Children's Hospital at Westmead and Cardiovascular Magnetic Resonance, Sydney, NSW, Australia.
Background: Quantification of right ventricular (RV) volumes is challenging owing to variable reproducibility and is especially so in congenital heart disease. Cardiac magnetic resonance (CMR) has the ability to more comprehensively survey the entire right ventricle and is currently considered the gold standard.
Aims: We aimed to determine the inter-observer reproducibility of CMR-derived RV volumes generated by two independent and experienced (SCMR Level III) observers in Tetralogy of Fallot (ToF) patients with varying degrees of RV dilatation.
The changing epidemiology of measles in an era of elimination: lessons from health-care-setting transmissions of measles during an outbreak in New South Wales, Australia, 2012.
Western Pac Surveill Response J
May 2017
National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (NCIRS), The Children's Hospital at Westmead and the University of Sydney, New South Wales.; Discipline of Paediatrics and Child Health, University of Sydney, The Children's Hospital at Westmead, Westmead, New South Wales.
Introduction: In countries where measles is rare, health-care-setting transmissions remain problematic. Australia experienced its largest measles outbreak in 15 years in 2012 with 199 cases reported nationally; 170 cases occurred in the state of New South Wales (NSW) with symptom onset between 7 April and 29 November 2012.
Methods: A descriptive study was conducted using measles case data obtained from metropolitan Sydney local health districts in NSW in 2012.
Optimizing Outcomes in Pediatric Renal Transplantation Through the Australian Paired Kidney Exchange Program.
Am J Transplant
February 2017
Royal Children's Hospital, Parkville, Victoria, Australia.
Kidney paired donation (KPD) programs offer the opportunity to enable living kidney donation when immunological and other barriers prevent safe directed donation. Children are likely to require multiple transplants during their lifetime; therefore, high-level histocompatibility and organ quality matching are key priorities. Details are given for a cohort of seven pediatric renal transplantations performed through the Australian Kidney Exchange (AKX), including barriers to alternative transplantation and outcomes after KPD.
View Article and Find Full Text PDFSafety and efficacy of the predictive low glucose management system in the prevention of hypoglycaemia: protocol for randomised controlled home trial to evaluate the Suspend before low function.
BMJ Open
April 2016
Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia, Australia School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
Introduction: Innovations with sensor-augmented pump therapy (SAPT) to reduce hypoglycaemia in patients with type 1 diabetes are an ongoing area of research. The predictive low glucose management (PLGM) system incorporates continuous glucose sensor data into an algorithm and suspends basal insulin before the occurrence of hypoglycaemia. The system was evaluated in in-clinic studies, and has informed the parameters of a larger home trial to study its efficacy and safety in real life.
View Article and Find Full Text PDFAn assessment of measles vaccine effectiveness, Australia, 2006-2012.
Western Pac Surveill Response J
September 2016
National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead and the University of Sydney, New South Wales, Australia . ; Discipline of Paediatrics and Child Health, University of Sydney, The Children's Hospital at Westmead, Westmead, New South Wales, Australia .
Objective: Vaccine effectiveness analysis serves as a critical evaluation for immunization programmes and vaccination coverage. It also contributes to maintaining public confidence with the vaccine providers. This study estimated measles vaccine effectiveness at the population level using Australian national notifications data between 2006 and 2012.
View Article and Find Full Text PDFMismatching between circulating strains and vaccine strains of influenza: Effect on Hajj pilgrims from both hemispheres.
Hum Vaccin Immunother
March 2016
a National Center for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead and the University of Sydney ; Sydney, NSW , Australia.
The trivalent seasonal influenza vaccine is expected to provide optimum protection if the vaccine strains match the circulating strains. The effect of worldwide mismatch between the vaccine strains and extant strains on travelers attending Hajj pilgrimage is not known. Annually 2-3 million Muslims coming from north and south hemispheres congregate at Hajj in Mecca, Saudi Arabia, where intense congestion amplifies the risk of respiratory infection up to eight fold.
View Article and Find Full Text PDFAustralian vaccine preventable disease epidemiological review series: mumps 2008-2012.
Commun Dis Intell Q Rep
March 2015
National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead and the University of Sydney, Westmead, New South Wales.
In 2007, Australia recorded the highest notification rate (2.8 per 100,000) for mumps since it became notifiable, with outbreaks in Western Australia and the Northern Territory. Of particular concern was the number of cases seen in vaccinated individuals.
View Article and Find Full Text PDFMiddle East respiratory syndrome coronavirus "MERS-CoV": current knowledge gaps.
Paediatr Respir Rev
June 2015
National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead, Westmead, NSW, Australia; Discipline of Paediatrics and Child Health, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, the University of Sydney, Sydney, NSW, Australia.
The Middle East respiratory syndrome coronavirus (MERS-CoV) that causes a severe lower respiratory tract infection in humans is now considered a pandemic threat to the Gulf region. Since its discovery in 2012, MERS-CoV has reached 23 countries affecting about 1100 people, including a dozen children, and claiming over 400 lives. Compared to SARS (severe acute respiratory syndrome), MERS-CoV appears to kill more people (40% versus 10%), more quickly, and is especially more severe in those with pre-existing medical conditions.
View Article and Find Full Text PDFInfectious causes of sudden infant death syndrome.
Paediatr Respir Rev
December 2014
National Centre for Immunisation Research and Surveillance (NCIRS), The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Centre for Perinatal Infection Research, The Children's Hospital at Westmead and The University of Sydney, Sydney, NSW, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity Institute (MBI), University of Sydney, Sydney, NSW, Australia.
Investigators have long suspected the role of infection in sudden infant death syndrome (SIDS). Evidence of infectious associations with SIDS is accentuated through the presence of markers of infection and inflammation on autopsy of SIDS infants and isolates of some bacteria and viruses. Several observational studies have looked into the relation between seasonality and incidence of SIDS, which often showed a winter peak.
View Article and Find Full Text PDFAustralian vaccine preventable disease epidemiological review series: pertussis, 2006-2012.
Commun Dis Intell Q Rep
September 2014
National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead and the University of Sydney, Westmead, New South Wales and Discipline of Paediatrics and Child Health, University of Sydney, The Children's Hospital at Westmead, Westmead, New South Wales.
Despite pertussis vaccine being available since the 1940s and immunisation programs using combined diphtheria-tetanus-pertussis vaccine since the mid-1950s, pertussis has been the most commonly notified vaccine preventable disease in Australia over the past 20 years. Pertussis notification and hospitalisation data have been available nationally since 1993, and provide different perspectives for understanding epidemiological trends. This report follows on from a previous review of Australian pertussis epidemiology from 1995-2005 and summarises routinely collected notification, hospitalisation and mortality data for 2006-2012.
View Article and Find Full Text PDFAntibody and cell-mediated immunity to pertussis 4 years after monovalent acellular pertussis vaccine at birth.
Pediatr Infect Dis J
May 2014
From the *National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead and the University of Sydney, New South Wales; †The Children's Hospital, Westmead, Sydney; ‡The University of Sydney, New South Wales, Australia; §Discipline of Paediatrics, School of Paediatrics and Reproductive Health and the Robinson Institute, The University of Adelaide; ¶Vaccinology and Immunology Research Trials Unit, Women's and Children's Hospital, Women's and Children's Health Network, South Australia; ‖Telethon Institute for Child Health Research and Centre for Child Health Research, Faculty of Medicine and Dentistry, The University of Western Australia, Perth; and **Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Background: In a previous study, we found that monovalent acellular pertussis (aP) vaccine at birth and 1 month achieves higher IgG antibody (Ab) levels to pertussis toxoid (PT), filamentous hemagglutinin (FHA) and pertactin by 8 weeks, when compared with controls. Here, we report antibody and cell-mediated immune responses to 4 years of age.
Methods: IgG Ab to PT, filamentous hemagglutinin and pertactin, diphtheria (D) and tetanus (T) was measured in the 3 groups (aP vaccine at birth and 1 month, aP birth only and no aP) at 2 years of age and before and after DTaP-inactivated polio vaccine (DTaP-IPV) at 4 years of age.
Editorial: "Infectious Diseases in Asia-Pacific: Historical and Contemporary Perspectives".
Infect Disord Drug Targets
November 2016
Has Hajj-associated Middle East Respiratory Syndrome Coronavirus transmission occurred? The case for effective post-Hajj surveillance for infection.
Clin Microbiol Infect
April 2014
National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead and The University of Sydney, Sydney, NSW, Australia.
An outbreak of staphylococcal food poisoning in a commercially catered buffet.
Commun Dis Intell Q Rep
June 2013
National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (NCIRS), The Children's Hospital at Westmead and the University of Sydney, New South Wales, Australia and National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.
Article Synopsis
- - Staphylococcal food poisoning is a prevalent type of foodborne illness, with around 30% of outbreaks in Australia linked to commercial catering since 2000.
- - A study investigated a 2012 outbreak among athletes where 22 participants fell ill after eating a buffet that included fried rice and chicken stir-fry, with specific bacteria found in some stool samples.
- - The outbreak was likely caused by contaminated food from an infected handler, highlighting the need for better reporting and understanding of staphylococcal foodborne illnesses.
Oral antibiotics confer small benefits and small harms in low-risk children with acute otitis media.
Evid Based Med
February 2014
Department of General Medicine, The Children's Hospital at Westmead and The University of Sydney, , Sydney, New South Wales, Australia.