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Upregulation of the creatine synthetic pathway in skeletal muscles of mature mdx mice.
Neuromuscul Disord
August 2007
Department of Pediatrics, University of Colorado-Denver Health Science Center, The Children's Hospital Fitzsimons Campus, Aurora, CO 80045, USA.
Article Synopsis
- Duchenne muscular dystrophy (DMD) is a severe muscle disease linked to a lack of dystrophin, but the mdx mouse lacks dystrophin yet shows milder symptoms, prompting research into its compensatory mechanisms.
- The study focuses on metabolic genes GAMT and AGAT involved in creatine synthesis, finding their mRNA and protein levels significantly increased in mdx muscle compared to controls.
- The heightened expression of GAMT suggests that enhancing the creatine synthesis pathway may help protect muscles from energy failures and could lead to potential treatments for DMD.