8 results match your criteria: "The Chenzhou Affiliated Hospital.[Affiliation]"
Unveiling the multifaceted pathogenesis and therapeutic drugs of Alzheimer's disease: A comprehensive review.
Heliyon
October 2024
Department of Physiology, Hengyang Medical School, University of South China, Hengyang, 421000, Hunan, China.
Alzheimer's disease (AD) is a severe neurodegenerative disorder characterized by the accumulation of β-amyloid (Aβ) plaques and tau phosphorylation-induced neurofibrillary tangles. This review comprehensively summarizes AD pathogenesis and related factors, drawing on a wealth of authoritative reports and research findings. Specifically, we delve into the intricate mechanisms underlying AD pathology, including Aβ deposition, tau protein phosphorylation, cholinergic dysfunction, neuroinflammation, mitochondrial oxidative stress, ferroptosis, imbalance in the gut microbiota, and microRNA dysregulation.
View Article and Find Full Text PDFSimultaneous CNV-seq and WES: An effective strategy for molecular diagnosis of unexplained fetal structural anomalies.
Heliyon
October 2024
Center of Prenatal Diagnosis, The Affiliated Chenzhou Hospital, Hengyang Medical School, University of South China, Chenzhou, 423000, China.
Background: Fetal structural anomalies are detected by ultrasound in approximately 3 % of pregnancies. Numerous genetic diagnostic strategies have been widely applied to identify the genetic causes of prenatal abnormalities. We aimed to assess the value of simultaneous copy number variation sequencing (CNV-seq) and whole exome sequencing (WES) in diagnosing fetuses with structural anomalies.
View Article and Find Full Text PDFICIs in hepatocellular carcinoma: A comprehensive analysis of path forward for multimodal treatment strategies.
Hepatol Commun
August 2024
Department of Pathology, Xiangtan Center Hospital, Xiangtan, China.
The application and therapeutic effect of botulinum toxin type a (BTX-A) in the treatment of patients with pain after cancer treatment: a systematic review and meta-analysis.
Int J Surg
February 2024
Department of Anesthesiology, The First People's Hospital of Chenzhou, The Chenzhou Affiliated Hospital.
Background: Botulinum toxin type A (BTX-A) is a potential treatment for cancer pain. This study aimed to analyze the effectiveness and safety of BTX-A in the treatment of pain after cancer treatment.
Patients And Methods: Systematic searches of PubMed, Cochrane Library, and Embase databases were conducted.
Low dose aspirin associated with greater bone mineral density in older adults.
Sci Rep
September 2022
Department of Joint Surgery, Chenzhou No.1 People's Hospital, Chenzhou, 423000, Hunan, China.
The use of low-dose aspirin in older adults is increasing as is the prevalence of osteoporosis. Aspirin has been shown in numerous studies to affect bone metabolism. However, there is no clear link between low-dose aspirin use and bone mineral density (BMD).
View Article and Find Full Text PDFCorrigendum: Pre-existing proton pump inhibitor treatment and short-term prognosis of acute myocardial infarction patients.
Front Cardiovasc Med
July 2022
Department of Emergency, The First People's Hospital of Chenzhou, Chenzhou, China.
[This corrects the article DOI: 10.3389/fcvm.2022.
View Article and Find Full Text PDFPre-existing Proton Pump Inhibitor Treatment and Short-Term Prognosis of Acute Myocardial Infarction Patients.
Front Cardiovasc Med
July 2022
Department of Emergency, The Chenzhou Affiliated Hospital, Hengyang Medical School, University of South China, Chenzhou, China.
Introduction: Evidence suspects proton pump inhibitor (PPI) use is a risk factor of poor prognosis of acute myocardial infarction (AMI). We aimed to investigate the association between pre-existing PPI use before emergency department (ED) visit and short-term prognosis of AMI patients.
Materials And Methods: AMI patients admitted to ED were included and categorized as cohorts with or without pre-existing PPI use.
Decreased miR-17-92 cluster expression level in serum and granulocytes preceding onset of antithyroid drug-induced agranulocytosis.
Endocrine
January 2018
Department of Metabolism & Endocrinology, the First Affiliated Hospital of University of South China, 69 Chuanshan Road, Hengyang, 421001, China.
Article Synopsis
- The study focused on how the miR-17-92 cluster changes in patients with agranulocytosis caused by antithyroid drugs (ATD), analyzing its expression in serum and granulocytes.
- The researchers used real-time PCR to measure miR-17-92 levels in 20 patients with agranulocytosis and 16 control patients, noting that six patients experienced changes in neutrophil counts.
- Results indicated that miR-17-92 levels were lower in both serum and granulocytes from agranulocytosis patients compared to controls and recovered patients, with no significant correlations found related to bone marrow type or thyroid hormone levels.