2 results match your criteria: "The Centre of Excellence in Cell-Extracellular Matrix Research[Affiliation]"
Renal blood flow and oxygenation drive nephron progenitor differentiation.
Am J Physiol Renal Physiol
August 2014
Rangos Research Center, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
During kidney development, the vasculature develops via both angiogenesis (branching from major vessels) and vasculogenesis (de novo vessel formation). The formation and perfusion of renal blood vessels are vastly understudied. In the present study, we investigated the regulatory role of renal blood flow and O2 concentration on nephron progenitor differentiation during ontogeny.
View Article and Find Full Text PDFCoordination of kidney organogenesis by Wnt signaling.
Pediatr Nephrol
April 2014
The Centre of Excellence in Cell-Extracellular Matrix Research, Oulu, Finland.
Several Wnt proteins are expressed in the embryonic kidney during various stages of development. Gene knockout models and ex vivo studies have provided strong evidence that Wnt-mediated signals are essential in renal ontogeny. Perhaps the most critical factors, Wnt9b and Wnt4, function during the early phase when the cap mesenchyme is induced to undergo morphogenesis into a nephron.
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