106 results match your criteria: "The Central Hospital of Enshi Autonomous Prefecture[Affiliation]"
Int Immunopharmacol
January 2019
Department of orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China. Electronic address:
Ivabradine is most commonly used for the treatment of worsening cardiac failure in patients who cannot tolerate the maximum dose of β-blockers or in whom treatment with β-blockers is contraindicated. While ivabradine is regarded as a highly selective "funny current" (I) inhibitor, the molecular mechanism behind the effect of this drug remains poorly understood. In the present study, we applied ivabradine in the context of osteoarthritis by treating primary human chondrocytes with tumor necrosis factor-α (TNF-α) and measuring degradation of the articular cartilage matrix as well as the expression of various enzymes and pro-inflammatory cytokines.
View Article and Find Full Text PDFInt J Food Sci Nutr
June 2019
a Department of Radiation Oncology , Renmin Hospital of Wuhan University, Wuhan , China.
This study aimed to clarify the association between serum total cholesterol (TC) levels and overall cancer risk. Study-specific relative risks (RR) and 95% confidence intervals (CI) were pooled using a random-effects model, and dose-response relation was also evaluated. Twelve prospective studies were identified with a total of 1,926,275 participants and 13,1676 cases.
View Article and Find Full Text PDFJ Cell Biochem
April 2019
Department of Radiology, The Central Hospital of Enshi Autonomous Prefecture, Enshi, China.
Colon adenocarcinoma (COAD) is one of the most common cancers, and its carcinogenesis and progression is influenced by multiple long non-coding RNAs (lncRNA), especially through the miRNA sponge effect. In this study, more than 4000 lncRNAs were re-annotated from the microarray datasets through probe sequence mapping to obtain reliable lncRNA expression profiles. As a systems biology method for describing the correlation patterns among genes across microarray samples, weighted gene co-expression network analysis was conducted to identify lncRNA modules associated with the five stepwise stages from normal colonic samples to COAD (n = 94).
View Article and Find Full Text PDFCancer Manag Res
October 2018
Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China,
Background: Colon cancer (CC) patients with early relapse usually have a poor prognosis. In this study, we aimed to identify a novel signature to improve the prediction of relapse-free survival (RFS) in CC.
Methods: Four microarray datasets were merged into a training set (n=1,045), and one RNA-sequencing dataset was used as a validation set (n=384).
Onco Targets Ther
October 2018
Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China,
Background And Aims: Gastric cancer (GC) is one of the most common cancers worldwide, and its pathogenesis is related to a complex network of gene interactions. The aims of our study were to find hub genes associated with the progression and prognosis of GC and illustrate the underlying mechanisms.
Methods: Weighted gene co-expression network analysis (WGCNA) was conducted using the microarray dataset and clinical data of GC patients from Gene Expression Omnibus (GEO) database to identify significant gene modules and hub genes associated with TNM stage in GC.
Aging (Albany NY)
September 2018
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Psychiatry Res
November 2018
Department of Anesthesiology, The Central Hospital of Enshi Autonomous Prefecture, Enshi 445000, China. Electronic address:
Some studies have indicated that ketamine has a rapid antidepressant effects, but the underlying molecular mechanism is still unclear. Researchers have found that mature brain-derived neurotrophic factor (mBDNF) and its precursor proBDNF are related to depression; they elicit opposite effects on cellular functions. It is clear that tissue plasminogen activator (tPA) is a key regulatory element in the conversion of proBDNF to mBDNF.
View Article and Find Full Text PDFEur J Pharmacol
November 2018
Pharmacological Center, Shandong New Time Pharmaceutical Co., Ltd, Linyi 273400, China; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd, Linyi 273400, China. Electronic address:
In this study, the pharmacokinetic properties and stability of isoliquiritigenin (ILQ) in microsomes were evaluated. The data showed ILQ administrated by i.h had high absorption degree (absolute bioavailability> 90%), and strong elimination ability (average t≈ 67 min).
View Article and Find Full Text PDFMedicine (Baltimore)
August 2018
Digestive Endoscopy Center Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan Department of Gastroenterology, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei Department of Gastroenterology Department of Intensive Care Unit, Haimen People's Hospital, Haimen, Nantong, Jiangsu, P.R. China.
Background: In recent years, Trichuris suis ova (TSO) therapy in inflammatory bowel disease (IBD) has attracted much attention. However, efficacy and safety of TSO therapy are still not well described. The aim of the study was to perform a meta-analysis to assess the effectiveness of TSO therapy in IBD.
View Article and Find Full Text PDFExp Ther Med
June 2018
Department of Gastroenterology, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei 445000, P.R. China.
The effect of microRNA (miRNA)-19a on gastrointestinal motility in rats with functional dyspepsia was investigated. Fifty adult Sprague-Dawley (SD) rats were randomly divided into 5 groups, 10 rats in each group, one group as the normal group, one group as the model group, and the other three groups were divided into negative control group, miRNA-19a mimic group and miRNA-19a inhibitor group. All rats were intraperitoneally injected with miRNA-19a scramble, miRNA-19a mimic and miRNA-19a inhibitor.
View Article and Find Full Text PDFAging (Albany NY)
May 2018
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Superovulation procedures and assisted reproductive technologies have been widely used to treat couples who have infertility problems. Although generally safe, the superovulation procedures are associated with a series of complications, such as ovarian hyper-stimulation syndrome, thromboembolism, and adnexal torsion. The role of long-term repeated superovulation in ovarian aging and especially in associated disorders such as osteoporosis and cardiovascular diseases is still unclear.
View Article and Find Full Text PDFWest J Nurs Res
April 2019
2 Sichuan University, Chengdu, Sichuan Province, China.
The purpose of the study was to examine the independent associations of each individual physical performance measure (i.e., grip strength, walking speed, repeated chair stands, and balance test) with subdomains of cognitive function and to determine predictors for each subdomain of cognitive function.
View Article and Find Full Text PDFMedicine (Baltimore)
May 2018
Department of Endocrinology The Second Department of Oncology, The Central Hospital of Enshi Autonomous Prefecture, Enshi, China.
Epidemiological studies exploring the role of flavonoids intake in preventing type 2 diabetes mellitus (T2DM) showed inconsistent results. Therefore, we performed a meta-analysis of relevant studies to examine the relationship between flavonoids intake and risk of T2DM. We hypothesized that flavonoids intake may decrease the risk of developing T2DM.
View Article and Find Full Text PDFInt Urol Nephrol
July 2018
West China Nursing School/West China Hospital, Sichuan University, Chengdu, 610061, Sichuan, China.
Purpose: The purpose of the study was to investigate the major factors affecting fatigue symptoms and to examine the relationships between fatigue symptoms and subjective and objective indicators in patients on hemodialysis (HD).
Methods: Patients on HD who met the inclusion criteria were chosen from two grade A tertiary general hospitals by convenience sampling and cross-sectional survey methods.
Results: A total of 511 patients were included in the study.
Medicine (Baltimore)
March 2018
Department of Pathology, The Central Hospital of Enshi Autonomous Prefecture Department of Hepatobiliary Surgery, The Central Hospital of Enshi Autonomous Prefecture, Enshi, China.
Background: The comparison between endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) and EUS guided fine needle biopsy (FNB) in sampling pancreatic masses is still controversial.
Methods: A systematic search was conducted in PubMed and Web of Science to identify all relevant randomized controlled trials (RCTs). Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated for dichotomous outcomes of interest (specimen adequacy, diagnostic accuracy, complications, and technical success), while mean difference (MD) and 95% CI were pooled for continuous variables (number of needle passes required for diagnosis).
Am J Clin Nutr
February 2018
Department of Gastroenterology, The Central Hospital of Enshi Autonomous Prefecture, Enshi, China.
Urolithiasis
April 2019
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
The objectives of the study are to compare the safety and efficacy of "all-seeing needle" optical puncture system micro-percutaneous nephrolithotomy (micro-PCNL) and flexible ureterorenoscopy (FURS) for the treatment of lower calyceal stones of ≤ 2 cm and to determine the advantages and disadvantages of each. 116 patients in total with lower calyceal stones of ≤ 2 cm were randomly divided into two equal groups, "all-seeing needle" optical puncture system micro-PCNL and FURS. In both groups, holmium laser was utilized for lithotripsy.
View Article and Find Full Text PDFInt J Infect Dis
March 2018
West China Nursing School/West China Hospital, Sichuan University, Chengdu, China. Electronic address:
Objectives: Continuous renal replacement therapy (CRRT) is a specialized type of dialysis. However, the characteristics and factors associated with nosocomial pneumonia in patients undergoing CRRT have received little attention to date. Therefore, this study investigated the characteristics of and factors contributing to nosocomial pneumonia in patients receiving CRRT.
View Article and Find Full Text PDFJ Cell Physiol
November 2018
Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Breast cancer is a kind of common female cancers. Increasing evidence has exhibited that lncRNAs exert a crucial role in breast cancer. So far, the mechanism of lncRNAs in breast cancer is still not well established.
View Article and Find Full Text PDFCancer Med
February 2018
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Current prognostic signatures need to be improved in identifying high-risk patients of gastric cancer (GC). Thus, we aimed to develop a reliable prognostic signature that could assess the prognosis risk in GC patients. Two microarray datasets of GSE662254 (n = 300, training set) and GSE15459 (n = 192, test set) were included into analysis.
View Article and Find Full Text PDFMol Med Rep
January 2018
Department of Spinal Surgery, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei 445000, P.R. China.
Osteosarcoma (OS) is the leading cause of cancer‑associated mortality in adolescents and children. MicroRNAs (miRNAs) have critical roles in cancer, particularly in the initiation and progression of OS. Therefore, OS‑associated miRNAs should be identified for use as therapeutic targets for treatment of OS.
View Article and Find Full Text PDFEur J Clin Nutr
February 2018
Department of Gastroenterology, The Central Hospital of Enshi Autonomous Prefecture, Enshi, 445000, China.
Oncotarget
November 2017
Department of Oncology, The Central Hospital of Enshi Autonomous Prefecture, Enshi 445000, China.
Dietary fat intake is potentially associated with the onset of esophageal carcinoma (EC), but evidence from observational studies has remained unclear. This study aimed to evaluate the role of fat intake in the development of esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). A systematic search was conducted in PubMed and Web of Science to identify all relevant studies.
View Article and Find Full Text PDFOncotarget
November 2017
Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
The role of intestinal lamina propria (LP) NKG2D+ NK cells is unclear in regulating Th1/Th2 balance in ulcerative colitis (UC). In this study, we investigated the frequency of LP NKG2D+ NK cells in DSS-induced colitis model and intestinal mucosal samples of UC patients, as well as the secretion of Th1/Th2/Th17 cytokines in NK cell lines after MICA stimulation. The role of Th1 cytokines in UC was validated by bioinformatics analysis.
View Article and Find Full Text PDFOncotarget
November 2017
Department of Gastroenterology, The Central Hospital of Enshi Autonomous Prefecture, Enshi, China.
Unlabelled: Although 14-day triple therapy has been widely administrated for eradicating in Asia, its antibiotic-associated side effects restrict the effectivity of eradication therapy in pediatric patients. Therefore, a network meta-analysis (NMA) was conducted to compare the efficacy and safety of probiotics supplemented in 14-day triple therapy in Asian pediatric patients.
Materials And Methods: Randomized controlled trials (RCTs) were retrieved comprehensively in electronic databases (such as PubMed, Cochrane library, Embase, CNKI, Wan fang database, VIP database and CBM) until April 2017.