20 results match your criteria: "The Center for the Prevention of Cardiovascular Disease[Affiliation]"

Background: The timing of antihypertensive drugs administration is controversial. The aim was to compare the efficacy of dosing of antihypertensive drugs in the morning versus evening.

Methods: A PubMed, EMBASE, and clinicaltrials.

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Prediabetes affects at least 1 in 3 adults in the U.S. and 1 in 5 in Europe.

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A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However, it is unknown if a PGS is associated with obstructive CAD and high-risk CAD phenotypes in patients with symptoms suggestive of CAD.

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Arsenic Exposure, Arsenic Metabolism, and Glycemia: Results from a Clinical Population in New York City.

Int J Environ Res Public Health

April 2021

Division of Cardiology and the Center for the Prevention of Cardiovascular Disease, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.

Little information is available regarding the glycemic effects of inorganic arsenic (iAs) exposure in urban populations. We evaluated the association of total arsenic and the relative proportions of arsenic metabolites in urine with glycemia as measured by glycated blood hemoglobin (HbA1c) among 45 participants with prediabetes (HbA1c ≥ 5.7-6.

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Fine particulate air pollution <2.5 μm in diameter (PM) is a major environmental threat to global public health. Multiple national and international medical and governmental organizations have recognized PM as a risk factor for cardiopulmonary diseases.

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Myocardial infarction accelerates breast cancer via innate immune reprogramming.

Nat Med

September 2020

NYU Cardiovascular Research Center, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, USA.

Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity or surgery, alters cancer pathogenesis. Patients with cancer, particularly those with breast cancer, can be at increased risk of cardiovascular disease due to treatment toxicity and changes in lifestyle behaviors. While elevated risk and incidence of cardiovascular events in breast cancer is well established, whether such events impact cancer pathogenesis is not known.

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Smooth Muscle Cell Reprogramming in Aortic Aneurysms.

Cell Stem Cell

April 2020

Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

The etiology of aortic aneurysms is poorly understood, but it is associated with atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) signaling in smooth muscle. Here, we investigated the interactions between these different factors in aortic aneurysm development and identified a key role for smooth muscle cell (SMC) reprogramming into a mesenchymal stem cell (MSC)-like state. SMC-specific ablation of TGF-β signaling in Apoe mice on a hypercholesterolemic diet led to development of aortic aneurysms exhibiting all the features of human disease, which was associated with transdifferentiation of a subset of contractile SMCs into an MSC-like intermediate state that generated osteoblasts, chondrocytes, adipocytes, and macrophages.

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Inflammasome Signaling and Impaired Vascular Health in Psoriasis.

Arterioscler Thromb Vasc Biol

April 2019

From the Center for the Prevention of Cardiovascular Disease, Department of Medicine (M.S.G., E.A.F., J.S.B.), New York University School of Medicine, New York.

Objective- Psoriasis is an inflammatory skin disease which heightens the risk of cardiovascular disease. This study directly investigated vascular endothelial health and systemically altered pathways in psoriasis and matched controls. Approach and Results- Twenty patients (mean age, 40 years; 50% male) with active psoriasis and 10 age-, sex-matched controls were recruited.

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Severe obesity and bariatric surgery alter the platelet mRNA profile.

Platelets

February 2020

Department of Medicine, Leon H. Charney Division of Cardiology and the Center for the Prevention of Cardiovascular Disease, New York University School of Medicine, New York , NY , USA.

Mechanisms explaining the relationship between obesity and cardiovascular disease (CVD) are needed. Despite growing recognition of the importance of the anucleate platelet transcriptome, low levels of RNA in platelets make assessment difficult. We sought to perform unbiased platelet RNA profiling in obesity by performing a prospective study of severe obesity and weight loss via bariatric surgery on platelet characteristics and mRNA profile in 26 pre-menopausal, non-diabetic women (31.

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Changes in High-Density Lipoprotein Cholesterol Efflux Capacity After Bariatric Surgery Are Procedure Dependent.

Arterioscler Thromb Vasc Biol

January 2018

From the Department of Medicine, Leon H. Charney Division of Cardiology and the Center for the Prevention of Cardiovascular Disease (S.P.H., B.L., J.S.B., E.A.F.), Department of Surgery (M.P.), and Department of Surgery, Division of Vascular Surgery, New York University Langone Medical Center (J.S.B.), New York University School of Medicine, New York; Department of Food Science and Experimental Nutrition, University of Sao Paulo, Brazil (B.S.); and Vascular Strategies LLC, Plymouth Meeting, PA (S.J.A., H.L.C.).

Objective: High-density lipoprotein cholesterol efflux capacity (CEC) is inversely associated with incident cardiovascular events, independent of high-density lipoprotein cholesterol. Obesity is often characterized by impaired high-density lipoprotein function. However, the effects of different bariatric surgical techniques on CEC have not been compared.

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Primary Prevention of Cardiovascular Disease in Diabetes Mellitus.

J Am Coll Cardiol

August 2017

Division of Cardiology and the Center for the Prevention of Cardiovascular Disease, Department of Medicine, New York University Medical Center; New York, New York.

Type 2 diabetes mellitus (T2D) is a major risk factor for cardiovascular disease (CVD), the most common cause of death in T2D. Yet, <50% of U.S.

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Hyperglycemia enhances arsenic-induced platelet and megakaryocyte activation.

J Transl Med

March 2017

Division of Cardiology and the Center for the Prevention of Cardiovascular Disease, Department of Medicine, New York University School of Medicine, TRB rm. 853, New York, NY, 10016, USA.

Objective: Low to moderate inorganic arsenic (iAs) exposure is independently associated with cardiovascular disease (CVD), particularly for patients with diabetes mellitus (DM). The mechanism of increased CVD risk from iAs exposure in DM has not been adequately characterized. We evaluated whether increasing concentrations of glucose enhance the effects of iAs on platelet and megakaryocyte activity, key steps in atherothrombosis.

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Inflammatory processes in cardiovascular disease: a route to targeted therapies.

Nat Rev Cardiol

March 2017

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, OX3 9DU, UK.

Inflammatory processes are firmly established as central to the development and complications of cardiovascular diseases. Elevated levels of inflammatory markers have been shown to be predictive of future cardiovascular events. The specific targeting of these processes in experimental models has been shown to attenuate myocardial and arterial injury, reduce disease progression, and promote healing.

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Regression of Atherosclerosis: The Journey From the Liver to the Plaque and Back.

Arterioscler Thromb Vasc Biol

February 2016

From the Department of Medicine (Cardiology), the Marc and Ruti Bell Program in Vascular Biology and the Center for the Prevention of Cardiovascular Disease, New York University School of Medicine.

Cardinal events in atherogenesis are the retention of apolipoprotein B-containing lipoproteins in the arterial wall and the reaction of macrophages to these particles. My laboratory has been interested in both the cell biological events producing apolipoprotein B-containing lipoproteins, as well as in the reversal of the damage they cause in the plaques formed in the arterial wall. In the 2013 George Lyman Duff Memorial Lecture, as summarized in this review, I covered 3 areas of my past, present, and future interests, namely, the regulation of hepatic very low density lipoprotein production by the degradation of apolipoprotein B100, the dynamic changes in macrophages in the regression of atherosclerosis, and the application of nanoparticles to both image and treat atherosclerotic plaques.

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How an artery heals.

Circ Res

November 2015

From the Section of Endocrinology, Diabetes, & Metabolism, Temple University School of Medicine, Philadelphia, PA (K.J.W.); Department of Molecular and Clinical Medicine, Sahlgrenska Academy of the University of Gothenburg, Göteborg, Sweden (K.J.W.); Departments of Medicine, Pathology & Cell Biology, and Physiology, Columbia University Medical Center, New York, NY (I.T.); and Department of Medicine (Cardiology), the Marc and Ruti Bell Program in Vascular Biology and The Center for the Prevention of Cardiovascular Disease, NYU School of Medicine, New York, NY (E.A.F.).

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Immunostaining of Macrophages, Endothelial Cells, and Smooth Muscle Cells in the Atherosclerotic Mouse Aorta.

Methods Mol Biol

April 2016

Marc and Ruti Bell Vascular Biology Program, Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, NY, 10016, USA.

The atherosclerotic mouse aorta consists of a heterogeneous population of cells, including macrophages, endothelial cells, and smooth muscle cells that play critical roles in cardiovascular disease. Identification of these vascular cells in the vessel wall is important to understanding their function in pathological conditions. Immunohistochemistry is an invaluable technique used to detect the presence of cells in different tissues.

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A current approach to statin intolerance.

Clin Pharmacol Ther

July 2014

The Center for the Prevention of Cardiovascular Disease, Leon H. Charney Division of Cardiology, NYU-Langone Medical Center, New York, New York, USA.

Statins are the first-line pharmacotherapy for cholesterol reduction. Use of these drugs in large randomized clinical trials has consistently shown significant reductions in major vascular events, including death, myocardial infarction, stroke, and coronary revascularization. The updated guidelines for the treatment of high blood cholesterol from the American College of Cardiology/American Heart Association (ACC/AHA), will lead to an increase in the number of patients taking statins.

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The impact of biotechnology on advances in cardiovascular medicine.

Trends Cardiovasc Med

October 2012

Elkan R. Blout Professor of Biological Sciences and the Director of the Center for the Prevention of Cardiovascular Disease and Division of Biological Sciences, Harvard School of Public Health Boston, MA 02115, USA; Professor of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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