548 results match your criteria: "The Center for Research[Affiliation]"
Experiencing pain: perspectives of Patrick D. Wall-founding editor of the journal PAIN.
Pain
January 2025
Department of Cell and Developmental Biology, Silberman Institute of Life Sciences, and the Center for Research on Pain, The Hebrew University of Jerusalem, Givat Ram Campus, Jerusalem, Israel.
Pain is a sensory and emotional experience. How did Pat Wall, founding editor of the journal PAIN and recognized pain guru, view the relation between the brain and the experience of pain? He was certain what it is not. It is not impulses in peripheral nociceptors that light up neurons in a central pain nucleus.
View Article and Find Full Text PDFEnteral nutritional practices in extremely preterm infants: a survey of U.S. NICUs.
J Perinatol
December 2024
Department of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Lateral violence and its effects on the health of sexual minority pre-service teachers in township schools in South Africa.
Cult Health Sex
December 2024
The Center for Research on School Climate, Georgia State University, Atlanta, GA, USA.
Article Synopsis
- Research indicates that teaching is a high-risk profession for lateral violence, which involves harmful behaviors among employees of similar or lower power.
- This study focused on the experiences of sexual minority pre-service teachers in South African township schools, using interviews to gather in-depth insights about their challenges.
- Findings highlight that these teachers face significant lateral violence mainly from school management and veteran teachers, which negatively affects their mental, physical, and social health, emphasizing the need for professional development around sexuality and gender diversity.
Predictors of intradialytic hypotension in critically ill patients undergoing kidney replacement therapy: a systematic review.
Intensive Care Med Exp
November 2024
Department of Critical Care, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Article Synopsis
- This systematic review investigates predictors of intradialytic hypotension (IDH) in critically ill patients receiving kidney replacement therapy (KRT) for acute kidney injury (AKI).
- It analyzed data from 8 studies with 2873 patients, finding that machine learning models, particularly Extreme Gradient Boosting Machine (XGB) and deep neural networks (DNN), had the highest predictive accuracy compared to traditional indicators.
- The study emphasizes the need for combining predictive models and clinical indicators to enhance prediction of IDH and highlights that further validation in different healthcare settings is necessary.
Randomized Trial of Very Early Medication Abortion.
N Engl J Med
November 2024
From the Department of Women's and Children's Health, Division of Obstetrics and Gynecology (K.B., K.G.-D.), and the Department of Clinical Sciences at Danderyd Hospital (H.K.K.), Karolinska Institutet, and the Department of Obstetrics and Gynecology, Karolinska University Hospital (K.G.-D.), Stockholm, Södertälje Hospital, Södertälje (K.B.), the Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg (T.J.-A., H.H.), the Department of Obstetrics and Gynecology, Skåne University Hospital, Malmö (P.T.), the Department of Clinical Sciences, Lund University Faculty of Medicine, Lund (P.T.), the Department of Clinical Sciences, Obstetrics, and Gynecology, Umeå University, Umeå (M.B.), and Statisticon, Uppsala (J.B.) - all in Sweden; the Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, and Chalmers Centre, NHS Lothian - both in Edinburgh (J.R.-W., S.C.); the Departments of Obstetrics and Gynecology (F.G., J.K., O.H.) and General Practice and Primary Health Care (F.G.), University of Helsinki and Helsinki University Hospital, Helsinki, and the Division of Health and Social Services, Wellbeing Services County of Vantaa and Kerava, Vantaa (F.G.) - both in Finland; the Center for Research on Environment, Health, and Population Activities, Kathmandu (A.T.), and KIST Medical College Teaching Hospital, Lalitpur (H.T.) - both in Nepal; Family Planning Australia, Sydney Medical School, University of Sydney, and the School of Public Health, University of Technology Sydney - all in Sydney (C.B.); Women's Health, Auckland City Hospital, Auckland, New Zealand (K.S., G.G.); the Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway (M.L.); and the Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Hvidovre (M.M.K.), and the Hospital of Southern Jutland, Aabenraa (E.K.) - both in Denmark.
Article Synopsis
- The study investigated the effectiveness and safety of medication abortion using mifepristone and misoprostol in women up to 42 days of gestation without confirmed intrauterine pregnancy using ultrasound.
- A total of 1504 women were randomly assigned to either an early-start abortion group or a standard delayed care group, and the primary outcome measured was the rate of complete abortion.
- The results showed a nearly identical rate of complete abortion between the two groups (95.2% early-start vs 95.3% standard), indicating that starting medication abortion before confirming intrauterine pregnancy is as safe and effective as standard care.
Protocolized fluid balance neutralization during continuous renal replacement therapy.
Intensive Care Med
December 2024
Division of Nephrology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Canada.
Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans.
N Engl J Med
October 2024
From the Department of Pediatrics, Duke University Medical Center, Durham (R.A.G.), and the Departments of Medicine (B.I.F.) and Biochemistry (N.D.P.), Wake Forest University School of Medicine, Winston-Salem - both in North Carolina; the Department of Medicine, University of Nigeria, Nsukka (I.U.), the Department of Medicine, College of Medicine, University of Ibadan, Ibadan (S. Ajayi, Y.R., A.D.A., A. Asinobi, O. Amodu, B.L.S.), the Department of Medicine, University of Ilorin, Ilorin (T.O.), the Department of Medicine, Obafemi Awolowo University, Ile-Ife (F.A.), the Department of Medicine, University of Abuja, Abuja, Nigeria (M. Mamven), the Department of Medicine, College of Medicine, University of Lagos, Lagos (T.A.), the Department of Medicine, College of Medicine, Lagos State University, Ojo (A.S., O. Awobusuyi), the Department of Medicine, Usmanu Danfodiyo University, Sokoto (M. Makusidi), Nnamdi Azikiwe University Teaching Hospital, Nnewi (U.O.), Delta State University Teaching Hospital, Oghara (O.O.), and Aminu Kano Teaching Hospital, Kano (A. Abdu) - all in Nigeria; the Department of Medicine, University of Ghana Medical School (C.O., M. Matekole, V.A., V.B., D.A.), and Noguchi Memorial Institute for Medical Research, University of Ghana (A.N., A.G.), Accra, the Department of Medicine, University of Cape Coast, Cape Coast (I.E.), and Kwame Nkrumah University of Science and Technology, Kumasi (J.P.-R., S. Antwi) - all in Ghana; the Basic Research Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick (C.A.W.), the Center for Research on Genomics and Global Health, National Human Genome Research Institute (A.A.A.), and the Division of Kidney, Urologic and Digestive Disease, National Institute of Diabetes and Digestive Kidney Diseases (P.L.K.), National Institutes of Health, Bethesda - all in Maryland; the Departments of Human Genetics (D.B.), Medicine (M.K.), and Pathology (J.B.H.), University of Michigan Medical School, Ann Arbor; the Parkinson School of Health Sciences and Public Health, Loyola University, Chicago (R.C., B.T.); the Department of Medicine, Boston University School of Medicine (T.O.I.), the Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School (M.R.P.), and the Departments of Pathology (B.C.) and Medicine (W.W.), Massachusetts General Hospital and Harvard Medical School - all in Boston; the Department of Medicine, College of Medicine, University of Arizona, Tucson (F.C.B.); the Departments of Biostatistics and Data Science (M.P., J.S.) and Medicine (C.I.A., J.W., A.O.), University of Kansas Medical Center, Kansas City, Kansas; and the Department of Medicine and Pediatrics, Women's College Hospital, Hospital for Sick Children and University of Toronto, Toronto (R.S.P.).
Background: Apolipoprotein L1 gene () variants are risk factors for chronic kidney disease (CKD) among Black Americans. Data are sparse on the genetic epidemiology of CKD and the clinical association of variants with CKD in West Africans, a major group in the Black population.
Methods: We conducted a case-control study involving participants from Ghana and Nigeria who had CKD stages 2 through 5, biopsy-proven glomerular disease, or no kidney disease.
Buparlisib and ponatinib inhibit aggressiveness of cholangiocarcinoma cells via suppression of IRS1-related pathway by targeting oxidative stress resistance.
Biomed Pharmacother
November 2024
Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address:
Cholangiocarcinoma (CCA) is an oxidative stress-driven liver cancer with bile duct epithelial cell phenotypes and currently lacks effective treatments, making targeted drug therapy urgently needed. Oxidative stress plays a critical role in CCA carcinogenesis, involving cells with oxidative stress resistance via upregulation of the PI3K and MEKK3 signaling pathways. In this study, we investigated the antineoplastic efficacy of a PI3K inhibitor (buparlisib) and a multi-tyrosine kinase inhibitor (ponatinib) on CCA.
View Article and Find Full Text PDFPhysiotherapists' perspectives on factors affecting the scope of in-home palliative care treatments: a qualitative study.
Physiother Theory Pract
October 2024
Department of Physical Therapy, Faculty of Social Welfare & Health Sciences, University of Haifa, Haifa, Israel.
Background: Physiotherapy has demonstrated significant benefits in enhancing quality of life and managing symptoms of people in need of palliative care (PC). Despite these benefits, palliative physiotherapy is infrequently integrated into community-based care, where most PC services are delivered. The limited prevalence of these treatments highlights the need to explore the factors influencing their delivery in home settings.
View Article and Find Full Text PDFThe QIBA Profile for Diffusion-Weighted MRI: Apparent Diffusion Coefficient as a Quantitative Imaging Biomarker.
Radiology
October 2024
From the Center for Research and Innovation, American College of Radiology, 50 S 16th St, Philadelphia, PA 19102 (M.A.B.); Department of Radiology, University of Michigan, Ann Arbor, Mich (D.M., T.L.C.); Department of Radiology, University of Washington, Seattle, Wash (S.P.); Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (N.O.); Departments of Medical Physics and Radiology, Memorial Sloan Kettering Cancer Center, New York, NY (A.S.D.); The Institute of Cancer Research, London, UK (J.M.W., N.M.d.S.); The Royal Marsden NHS Foundation Trust, London, UK (J.M.W., N.M.d.S.); Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Tex (C.D.F.); CaliberMRI, Boulder, Colo (K.M.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (V.M.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, Calif (M.O., L.J.W.); Aim Medical Imaging, Vancouver, Canada (R.A.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (T.A.); and Department of Radiology, Weill Cornell Medical College, New York, NY (D.J.M.).
Article Synopsis
- The Apparent Diffusion Coefficient (ADC) measures how water moves in tissues, helping doctors see changes caused by diseases or treatments.
- The QIBA has made progress on using ADC measurements in different body parts like the brain, liver, prostate, and breast, by creating guidelines for their use.
- The report explains the right amounts of change in ADC values that indicate real differences in tissue, helping doctors track patients’ health more accurately.
More Than 1.4 Million US Children Have Lost a Family Member to Drug Overdose.
Am J Public Health
December 2024
Ashton M. Verdery is with the Department of Sociology and Criminology and the Institute for Computational and Data Sciences, and Cayley Ryan-Claytor is with the Department of Sociology and Criminology, Pennsylvania State University, University Park. At the time of the study, Nilakshi Sarkar was with the Department of Psychology, Pennsylvania State University, University Park. Emily Smith-Greenaway is with the Department of Sociology and the Spatial Sciences Institute, University of Southern California, Los Angeles. Michelle Livings is with the Center for Research on Child and Family Wellbeing, Princeton University, Princeton, NJ.
To estimate children's exposure to family overdose in the United States. We used recent demographic kinship modeling advances and the Centers for Disease Control and Prevention's most recent underlying cause of death estimates to model how many children aged younger than 18 years in 2019 had lost 1 or more parents, siblings, grandparents, aunts or uncles, or cousins to overdose mortality since birth. We calculated the number and proportion of children with such exposures and considered age, cohort, and gender patterning.
View Article and Find Full Text PDFComparison of the Diagnostic Accuracy of Teledermoscopy, Face-to-Face Examinations and Artificial Intelligence in the Diagnosis of Melanoma.
Indian J Dermatol
August 2024
From the Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Rapid diagnosis of melanoma is crucial for better patient outcomes, and this study evaluates the effectiveness of teledermoscopy using the FotoFinder device and Moleanalyzer Pro AI compared to in-person clinical exams.
- The study involved 30 melanocytic moles from 29 patients, analyzing the sensitivity and specificity of the three diagnosis methods against histopathological results.
- Results showed that face-to-face exams had the highest sensitivity and specificity, while the teledermoscopy provided better agreement with pathology than the AI method, indicating that AI cannot fully replace dermatologists' expertise.
Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia.
N Engl J Med
September 2024
From Respiratory Medicine, Allergology, and Palliative Medicine, Department of Clinical Sciences in Lund, Faculty of Medicine, Lund University, Lund (M.E., F.B.), the Department of Medicine, Blekinge Hospital, Karlskrona (M.E.), the COPD Center, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg (A.A.), and the Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital (S.P.), Gothenburg, Karlstad County Hospital, Karlstad (T.K.), Northern Älvsborg County Hospital, Trollhättan (B.P.), Linköping University Hospital, Linköping (O.K.), Falun Hospital, Falun (P.S.), the Department of Respiratory Medicine and Allergology, Faculty of Medicine, Karolinska University Hospital (M.R.), and Karolinska University Hospital Huddinge (R.H.), Stockholm, the Department of Medical Sciences, Respiratory, Allergy, and Sleep Research, Uppsala University (A.P., E.L., C.J.), and the Uppsala Clinical Research Center (N.H.), Uppsala, the Center for Research and Development, Gävle Hospital, Gävle (A.P.), the Department of Public Health and Clinical Medicine, Umeå University, Umeå (A.B.), Sundsvall-Härnösand County Hospital, Sundsvall (B.S.), and the Department of Respiratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro (J.S.) - all in Sweden; the Institute for Breathing and Sleep and the Department of Respiratory and Sleep Medicine, Austin Health, Melbourne, VIC (C.F.M.), and the Graduate School of Medicine, Faculty of Science, Medicine, and Health, University of Wollongong, Wollongong, NSW (D.C.C.) - both in Australia.
Background: Long-term oxygen supplementation for at least 15 hours per day prolongs survival among patients with severe hypoxemia. On the basis of a nonrandomized comparison, long-term oxygen therapy has been recommended to be used for 24 hours per day, a more burdensome regimen.
Methods: To test the hypothesis that long-term oxygen therapy used for 24 hours per day does not result in a lower risk of hospitalization or death at 1 year than therapy for 15 hours per day, we conducted a multicenter, registry-based, randomized, controlled trial involving patients who were starting oxygen therapy for chronic, severe hypoxemia at rest.
Characterization of flare-ups and impact of garetosmab in adults with fibrodysplasia ossificans progressiva: a post hoc analysis of the randomized, double-blind, placebo-controlled LUMINA-1 trial.
J Bone Miner Res
September 2024
Department of Medicine, Mayo Clinic, Rochester, MN 55905, United States.
Article Synopsis
- Fibrodysplasia ossificans progressiva (FOP) is a rare disorder causing painful flare-ups and abnormal bone growth, known as heterotopic ossification (HO).
- In a clinical trial, patients receiving the anti-activin A antibody garetosmab experienced fewer severe and lengthy flare-ups compared to those given a placebo, leading to a notable difference in quality of life.
- The study found that 71% of placebo patients had flare-ups linked to new HO lesions, while garetosmab reduced the severity, duration, and frequency of these flare-ups throughout the trial.
Survey of vitamin D supplementation practices in extremely preterm infants.
Pediatr Res
August 2024
Department of Pediatrics, Division of Perinatal-Neonatal Medicine, University of Texas Health Science Center Houston, McGovern Medical School, Houston, TX, USA.
Background: Most extremely preterm (EP) infants are vitamin D deficient (serum 25-hydroxyvitamin D levels below 20 ng/mL), and optimal supplementation practices for EP infants remain unknown. Our objective is to assess current vitamin D supplementation practices in U.S.
View Article and Find Full Text PDFRising incidence of obesity-related cancers among younger adults in China: A population-based analysis (2007-2021).
Med
November 2024
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Diabetes Institute, Beijing 100730, China; Beijing Key Laboratory of Diabetes Research and Care, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China. Electronic address:
Background: Developing countries face an "obesity epidemic," particularly affecting children and younger adults. While obesity is a known risk factor for 12 types of cancer, primarily affecting older populations, its impact on younger generations is understudied.
Methods: This study analyzed data from a population-based cancer registry covering 14.
Pathological and Immunohistochemical Assessment of Aging of the Abdominal Skin Treated with Carboxytherapy: A Randomized, Split-body Trial.
J Clin Aesthet Dermatol
August 2024
Drs Abdolhosseini and Tavoosidana are with the Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences in Tehran, Iran.
Background: Skin aging as a continuous and irreversible process is mainly the result of alterations of function and structure of the dermis. Among the modalities used for treating skin aging, carboxytherapy has been introduced as a safe minimally-invasive method for rejuvenation, reparation, and reconditioning of the skin.
Objective: We assessed the efficacy of carboxytherapy for the treatment of intrinsic skin aging through pathological and immunohistochemical (IHC) investigations.
Trauma center rehabilitation systems in Latin America.
OTA Int
July 2024
Serviço de Ortopedia e Traumatologia Prof. Nova Monteiro, Hospital Municipal Miguel Couto, Rio de Janeiro, Brazil.
Trauma is a leading cause of mortality and morbidity worldwide with high rates of disability in survivors. With improvements in care, rehabilitation of the trauma patient is a cornerstone to reducing sequelae. A lack of well-established hospital rehabilitation units and standardized protocols for managing posttraumatic injuries is a common problem in Latin American countries.
View Article and Find Full Text PDFExploring Cancer Incidence Trends by Age and Sex Among 14.14 Million Individuals in China From 2007 to 2021: Population-Based Study.
JMIR Public Health Surveill
August 2024
Beijing Key Laboratory of Diabetes Research and Care, Department of Endocrinology and Metabolism, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Background: Sex is a crucial factor in the development, progression, and treatment of cancer, making it vital to examine cancer incidence trends by sex for effective prevention strategies.
Objective: This study aimed to assess the incidence of cancer in China between 2007 and 2021, with a focus on sex-based trends.
Methods: A population-based cancer registry comprising 14.
Wound Care Capacity of the Addiction Workforce in the Setting of Xylazine.
J Addict Med
November 2024
From the Center for Research on Healthcare, University of Pittsburgh School of Medicine, Pittsburgh, PA (RJ, MS); Grayken Center for Addiction Training and Technical Assistance, Boston Medical Center, Boston, MA (RJ, SB, SM, ASV, TH, AW, CLB); and Boston Health Care for the Homeless Program, Boston, MA (TJ).
Objectives: As xylazine increasingly adulterates the unregulated opioid supply, people who use drugs (PWUD) are more likely to experience sequalae from xylazine. Given xylazine exposure is consistently associated with development of wounds which can heal with medically directed wound care, we sought to understand the level of preparedness and ability of front-line addiction professionals who interact with PWUD to provide wound care treatment.
Methods: We administered a 26-item online survey assessing participant and organizational characteristics, level of wound care training, ability to test for xylazine and treat xylazine-associated wounds, and funding and billing characteristics to a national sample of addiction professionals using a listserv of over 11,000 individuals.
Cognition and communication in patients with spinal muscular atrophy: A systematic review.
Heliyon
July 2024
Université Libre de Bruxelles, ULB, Hôpital Universitaire de Bruxelles (HUB), Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), Department of Paediatric Neurology and Neuromuscular Reference Center, Brussels, Belgium.
•Synthesizes evidence from 12 studies on cognitive and communicative impacts in SMA, focusing on nuanced functional outcomes.•Highlights cognitive variability in SMA1, revealing subtle challenges in SMA2 and 3, and stresses tailored assessment methodologies.•Identifies communication barriers in SMA, emphasizing the urgency of investigating their potential interplay with cognitive functions.
View Article and Find Full Text PDFBehind the scenes: Key lessons learned from the RELIEVE-AKI clinical trial.
J Crit Care
October 2024
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address:
Continuous kidney replacement therapy (CKRT) is commonly used to manage critically ill patients with severe acute kidney injury. While recent trials focused on the correct dosing and timing of CKRT, our understanding regarding the optimum dose of net ultrafiltration is limited to retrospective data. The Restrictive versus Liberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury (RELIEVE-AKI) trial has been conducted to assess the feasibility of a prospective randomized trial in determining the optimum net ultrafiltration rate.
View Article and Find Full Text PDFThe Holocaust Experience and Its Role in the Association Between Meaning in Life, Depressive Symptoms and Life Satisfaction.
J Gerontol Soc Work
October 2024
Department of Gerontology, The Center for Research and Study of Aging, University of Haifa, Haifa, Israel.
Holocaust survivors often reveal long-term depressive symptoms, while demonstrating life satisfaction. The present study examined the role of meaning in life (MIL) of Holocaust survivors in this context. Survivors ( = 44) and comparisons ( = 51) provided background information and completed MIL, depressive symptoms, and life satisfaction scales.
View Article and Find Full Text PDFEffect of Routine Child Physical Abuse Screening Tool on Emergency Department Efficiency.
Pediatr Emerg Care
July 2024
UCHealth Memorial Hospital Central, Colorado Springs, CO.
Objectives: Physical abuse is a significant cause of morbidity and mortality for children. Routine screening by emergency nurses has been proposed to improve recognition, but the effect on emergency department (ED) workflow has not yet been assessed. We sought to evaluate the feasibility of routine screening and its effect on length of stay in a network of general EDs.
View Article and Find Full Text PDFMultiplexed serum biomarkers to discriminate nonviable and ectopic pregnancy.
Fertil Steril
September 2024
Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Objective: To evaluate combinations of candidate biomarkers to develop a multiplexed prediction model for identifying the viability and location of an early pregnancy. In this study, we assessed 24 biomarkers with multiple machine learning-based methodologies to assess if multiplexed biomarkers may improve the diagnosis of normal and abnormal early pregnancies.
Design: A nested case-control design evaluated the predictive ability and discrimination of biomarkers in patients at risk of early pregnancy failure in the first trimester to classify viability and location.