1 results match your criteria: "The Center for AIDS Prevention and Control[Affiliation]"
Mechanism of Se-Indocalamus tessdatus polycassine(S-ITPS) against human immunodeficiency virus type 1 (HIV-1).
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
March 2000
The Center for AIDS Prevention and Control, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Objective: To study the mechanism of Se- Indochalamus tessdatus polycassine (S-ITPS) against HIV-1 and to provide a theoretical support for developing the anti-HIV drugs.
Methods: S-ITPS was added to MT4 cells before viral inoculation, at the same time of viral inoculation, then the cells were cultured with or without S-ITPS for 1-4 weeks, finally, cytopathic effect (CPE), MTT staining method for viable cells(MTT assay),p24 antigen titer (ELISA), or infectivity (TCID50 assay) of the cultural supernatants were used as markers to monitor the virus growth.
Results: S-ITPS can inhibit HIV-induced CPE (1C50 = l0microg/ml)and viral replication (1C50 = 156 microg/ml)in dose dependent manner.