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Elevated serum levels of syndecan-1 are associated with renal involvement in patients with systemic lupus erythematosus.
J Rheumatol
February 2015
From the Division of Rheumatology, The Catholic University of Korea, Seoul, Republic of Korea.K-J. Kim, MD, Division of Rheumatology, St. Vincent Hospital, The Catholic University of Korea; J-Y. Kim, PhD, Institute of Bone and Joint Diseases, Catholic Research Institutes of Medical Sciences, The Catholic University of Korea; I-W. Baek, MD, Division of Rheumatology, Yeouido St. Mary's Hospital, The Catholic University of Korea; W-U. Kim, MD, PhD, Division of Rheumatology, Seoul St. Mary's Hospital, The Catholic University of Korea; C-S. Cho, MD, PhD, Division of Rheumatology, Yeouido St. Mary's Hospital, The Catholic University of Korea.
Objective: Syndecan-1 (SDC-1) is a major constituent of the endothelial glycocalyx, which plays a role in maintaining vascular homeostasis and functions as a glomerular filtration barrier. SDC-1 is readily shed into the blood under various conditions, but the clinical implication of circulating SDC-1 in patients with systemic lupus erythematosus (SLE) remains unclear. We aimed to investigate the association of serum SDC-1 level with certain clinical manifestations of SLE.
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