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Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer's disease.

Acta Neuropathol Commun

May 2021

Department of Medical Biochemistry and Microbiology, SciLifeLab Uppsala, University of Uppsala, The Biomedical Center Husargatan 3, Box 582, 751 23, Uppsala, Sweden.

Defective amyloid-β (Aβ) clearance from the brain is a major contributing factor to the pathophysiology of Alzheimer's disease (AD). Aβ clearance is mediated by macrophages, enzymatic degradation, perivascular drainage along the vascular basement membrane (VBM) and transcytosis across the blood-brain barrier (BBB). AD pathology is typically associated with cerebral amyloid angiopathy due to perivascular accumulation of Aβ.

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