2 results match your criteria: "The Babies and Children's Hospital of New York[Affiliation]"

Ameliorating anthracycline cardiotoxicity in children with cancer: clinical trials with dexrazoxane.

Semin Oncol

August 1998

Department of Pediatrics, College of Physicians and Surgeons of Columbia University, The Babies and Children's Hospital of New York, New York 10032, USA.

Anthracyclines have major activity against a broad range of childhood cancers. Concern over the risk of long-term cardiotoxicity associated with their use has called into question the role of these agents in the frontline treatment of many patients. Dexrazoxane was developed as a specific cardioprotectant "antidote" which can prevent anthracycline cardiotoxicity without inhibiting its antitumor effect.

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Background: Exposure to environmental tobacco smoke is associated with detrimental effects on pulmonary function in children. The authors investigated the relation between airway complications in children receiving general anesthesia and the passive inhalation of tobacco smoke.

Methods: Six hundred two children scheduled to receive general anesthesia were enrolled in this prospective study.

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