Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia.

Introduction: L-Asparaginase (L-Asp) is a key drug in the treatment of acute lymphoblastic leukemia (ALL); however, it is commonly associated with the occurrence of adverse events (AE). Risk factors such as age, sex, nutritional status, and some single nucleotide variants (SNVs) in specific genes could be related to hypersensitivity reactions to L-Asp. The objective of this study was to identify the influence of individual characteristics and three SNVs in the and genes on the occurrence of the most significant adverse events caused by the use of L-Asp in Mexican children with ALL.

Antibacterial Effects of Silver Diamine Fluoride with and without Potassium Iodide against .

Introduction: Silver diamine fluoride (SDF) is a topical treatment for carious lesions and a primary preventative for newly exposed high-risk surfaces such as fissures and roots in the first molars. Using potassium iodide (KI) after applying SDF has been recommended as a way of reducing the severity of black staining, as well as preserving its antibacterial effect useful in deep caries.

Objective: The objective of this research was to compare the antibacterial effect of SDF, with and without KI, on (.

[Cardiovascular risk factors in young Mexican adults].

Background: Cardiovascular diseases (CVDs) are the main cause of morbidity and mortality in the adult population worldwide. Most studies on risk factors have focused on children and adults of mature age. Quite the opposite, there are few which specifically analyze young individuals.

Clinical and non-clinical variables associated with preventive and curative dental service utilisation: a cross-sectional study among adolescents and young adults in Central Mexico.

Objective: The present study aimed to identify preventive and curative dental health service utilisation (DHSU) in the context of associated clinical and non-clinical factors among adolescents and young adults in Mexico.

Design: Cross-sectional study.

Setting: Applicants to a public university in Mexico.

Out-Of-Pocket Expenditures on Dental Care for Schoolchildren Aged 6 to 12 Years: A Cross-Sectional Estimate in a Less-Developed Country Setting.

: The objective of this study was to estimate the Out-Of-Pocket Expenditures (OOPEs) incurred by households on dental care, as well as to analyze the sociodemographic, economic, and oral health factors associated with such expenditures. : A cross-sectional study was conducted among 763 schoolchildren in Mexico. A questionnaire was distributed to parents to determine the variables related to OOPEs on dental care.

Acid resistance and structural changes of human dental enamel treated with Er:YAG laser.

Objective: The purpose of this study was to evaluate the acid resistance and structural changes in the enamel surface of permanent teeth after subablative Er:YAG laser irradiation in vitro.

Background Data: Er:YAG irradiation laser is expected to enhance acid resistance and to produce morphological changes on the enamel surface.

Methods: One hundred twenty samples of human enamel were divided into four groups (n = 30): Group I was the control (no laser irradiation), and Groups II, III, and IV were irradiated with Er:YAG laser at 100 mJ (12.