Structural dynamics of human deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase).

Structural- and functional heterogeneity, as well as allosteric regulation, in homo-monomeric enzymes is a highly active area of research. One such enzyme is human nuclear-associated deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase), which has emerged as an interesting drug target in combination therapy with traditional nucleotide analogue treatment of cancer. We report, for the first time, a full structural dynamics study of human dUTPase by NMR.

Production of Cu at a biomedical cyclotron via Zn(p,α)Cu reaction and its evaluation in a preclinical study using small animal SPECT/CT.

Clinical advancements in nuclear medicine theranostics has excited a research interest in exploring novel radionuclides for medical use. The duo of the β emitter Cu and the positron emitter Cu, has advantages over the well-established clinical pair Ga and Lu in terms of capability for high-precision therapy. Low availability has hindered the use of Cu whereas Cu has become established at a limited number of sites through production in low-to-medium energy biomedical cyclotrons.

Agreement between child- and parent-reported orofacial symptoms in patients with juvenile idiopathic arthritis.

Objective: To assess the agreement between child- and parent-reported orofacial symptoms in the Danish version of the patient questionnaire Assessment of Orofacial Symptoms in Juvenile Idiopathic Arthritis.

Method: This cross-sectional study was conducted at Aarhus University in March 2023. Eligible candidates were consecutive subjects with juvenile idiopathic arthritis (JIA) and temporomandibular joint involvement accompanied by a parental proxy for examination in the Craniofacial Clinic.

Effects of oxygen levels and temperature on growth and physiology of pikeperch juveniles cultured in a recirculating aquaculture system.

This study aimed to understand how environmental factors, specifically water temperature and oxygen saturation, affect the growth performance and physiology of pikeperch (Sander lucioperca) juveniles in recirculating aquaculture systems (RASs). Given the importance of optimising growth conditions in aquaculture to maximise efficiency, it aims to assess whether different combinations of oxygen levels and temperatures can enhance growth while maintaining the physiological health and welfare of the fish. The experimental design included the culturing pikeperch juveniles (22.

Weathering words: a virtual reality study of environmental influence on reading dynamics.

Introduction: Reading is a fundamental cognitive activity that is influenced by both textual and external environmental factors, although the latter has been less thoroughly explored. This study aims to examine the impact of environmental visual conditions on reading performance using Virtual Reality (VR) technology.

Methods: We conducted two experiments to assess the effects of visual contrast and simulated weather conditions on reading dynamics.

Large language models to facilitate pregnancy prediction after in vitro fertilization.

We evaluated the efficacy of large language models (LLMs), specifically, generative pre-trained transformer-4 (GPT-4), in predicting pregnancy following in vitro fertilization (IVF) treatment and compared its accuracy with results from an original published study. Our findings revealed that GPT-4 can autonomously develop and refine advanced machine learning models for pregnancy prediction with minimal human intervention. The prediction accuracy was 0.

Arctic freshwater outflow suppressed Nordic Seas overturning and oceanic heat transport during the Last Interglacial.

The Last Interglacial period (LIG) was characterized by a long-term Arctic atmospheric warming above the preindustrial level. The LIG thus provides a case study of Arctic feedback mechanisms of the cryosphere-ocean circulation-climate system under warm climatic conditions. Previous studies suggested a delay in the LIG peak warming in the North Atlantic compared to the Southern Ocean and evoked the possibility of southward extension of Arctic sea ice to the southern Norwegian Sea during the early LIG.

Appetite Loss in Patients with Advanced Cancer Treated at an Acute Palliative Care Unit.

Appetite loss is prevalent in patients with advanced cancer and negatively affects their quality of life. However, understanding of the factors associated with appetite loss is limited. The current study aims to explore characteristics and therapeutic interventions used for patients with and without appetite loss admitted to an acute palliative care unit.

Looks at what isn't there: eye movements on a blank screen when processing negation in a first and a second language.

Is negation more difficult to process than affirmation? If it is, does processing negation in a second language (L2) compound the difficulty compared to the first language (L1)? This article addresses the issues of difficulties in processing different types of negation in the L1 and L2 by looking at the differences in the ways in which comprehenders anticipate upcoming visual information during sentence processing. Using a blank-screen paradigm, we recorded eye fixations of Croatian native speakers and Croatian learners of English while they were anticipating matching or mismatching pictures to sentences with various types of negation in L1 (Croatian) and L2 (English). Using a between-group design, we manipulated sentence polarity (affirmative vs.

The role of indirect interspecific effects in the stochastic dynamics of a simple trophic system.

Indirect interspecific effects (IIEs) occur when one species affects another through a third intermediary species. Understanding the role of IIEs in population dynamics is key for predicting community-level impacts of environmental change. Yet, empirically teasing apart IIEs from other interactions and population drivers has proven challenging and data-demanding, particularly in species-rich communities.

Sámi Healthcare Staff Experiences of Encounters with Sámi Patients and Their Expectations for Non-Sámi Healthcare Staff.

Objective: The aim of this study was to explore Sámi healthcare staff experiences in encounters with Sámi patients and their expectations for non-Sámi healthcare staff.

Methods: Focus groups and individual interviews with 14 participants were conducted, and the participants' experiences were subjected to a thematic analysis approach.

Results: The findings show that the Sámi healthcare staff expect non-Sámi healthcare staff to enhance their knowledge about Sámi language and culture.

Validity of the Johns Hopkins Adjusted Clinical Groups system on the utilisation of healthcare services in Norway: a retrospective cross-sectional study.

Background: The Adjusted Clinical Groups (ACG) System is a validated electronic risk stratification system. However, there is a lack of studies on the association between different ACG risk scores and the utilisation of different healthcare services using different sources of input data. The aim of this study was therefore to assess the validity of the association between five different ACG risk scores and the utilisation of a range of different healthcare services using input data from either general practitioners (GPs) or hospitals.

A randomized trial on three different minimally invasive decompression techniques for lumbar spinal stenosis. Five years follow-up from the NORDSTEN-SST.

Purpose: The short-term clinical outcome for midline-preserving posterior decompression techniques was comparable. The aim of this study was to evaluate long-term clinical results after three different midline-preserving posterior decompression techniques.

Material: In the NORDSTEN spinal stenosis trial (NORDSTEN-SST) 437 patients were randomized to three different midline-retaining posterior decompression techniques: Unilateral laminotomy with crossover (UL), bilateral laminotomy (BL) and spinous process osteotomy (SPO).

Effectiveness of a Bullying Intervention (Be-Prox) in Norwegian Early Childhood and Education Care Centers: Protocol for a Cluster Randomized Controlled Trial.

Background: A new and growing body of research has studied bullying among children in early childhood education and care centers (ECECs). The Bernese Program (Be-Prox) is designed to systematically prevent and handle bullying between children in Swiss ECECs. However, the effectiveness of the Be-Prox intervention has not yet been explored in a Norwegian ECEC setting.

Roles of miR-20a-5p in breast cancer based on the clinical and multi-omic (CAMO) cohort and in vitro studies.

MicroRNAs are involved in breast cancer development and progression, holding potential as biomarkers and therapeutic targets or tools. The roles of miR-20a-5p, a member of the oncogenic miR-17-92 cluster, remain poorly understood in the context of breast cancer. In this study, we elucidate the role of miR-20a-5p in breast cancer by examining its associations with breast cancer risk factors and clinicopathological features, and its functional roles in vitro.

Influence of Menstrual-Cycle Phase on Sleep and Recovery Following High- and Low-Intensity Training in Eumenorrheic Endurance-Trained Women: The Female Endurance Athlete Project.

Purpose: To investigate the influence of menstrual-cycle (MC) phase on objective sleep and perceived recovery following high- (HIT) and low-intensity training (LIT) in endurance-trained women.

Methods: Fifteen naturally menstruating, endurance-trained women completed standardized HIT and LIT sessions during the early follicular phase (EFP), ovulatory phase (OP), and midluteal phase (MLP) of 2 MCs. Overnight sleep was monitored using a Somnofy sleep monitor after each training session, and perceived recovery was assessed after 24 hours using self-report scales.

PFAS Exposure is Associated with a Lower Spermatic Quality in an Arctic Seabird.

Several studies have reported an increasing occurrence of poly- and perfluorinated alkyl substances (PFASs) in Arctic wildlife tissues, raising concerns due to their resistance to degradation. While some research has explored PFAS's physiological effects on birds, their impact on reproductive functions, particularly sperm quality, remains underexplored. This study aims to assess (1) potential association between PFAS concentrations in blood and sperm quality in black-legged kittiwakes (), focusing on the percentage of abnormal spermatozoa, sperm velocity, percentage of sperm motility, and morphology; and (2) examine the association of plasma levels of testosterone, corticosterone, and luteinizing hormone with both PFAS concentrations and sperm quality parameters to assess possible endocrine disrupting pathways.

Mouse liver sinusoidal endothelial cell responses to the glucocorticoid receptor agonist dexamethasone.

Liver sinusoidal endothelial cells (LSECs) which make up the fenestrated wall of the hepatic sinusoids, are active scavenger cells involved in blood waste clearance and liver immune functions. Dexamethasone is a synthetic glucocorticoid commonly used in the clinic and as cell culture supplement. However, the response is dependent on tissue, cell type, and cell state.

Validity of self-reported number of pregnancies and maternal age at first birth among females attending organized mammographic screening.

Aims: Reproductive history conveys information about potential health risks later in adulthood. This study aimed to examine the validity of self-reported number of pregnancies and maternal age at first birth (AFB) among females attending BreastScreen Norway.

Methods: Participants were identified through the Janus Serum Bank cohort in Norway and were eligible for this cross-sectional validation study if they participated in a health survey issued by BreastScreen Norway between 2006 and 2015.