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Background: Mature lysostaphin (~28-kDa Lss) from Staphylococcus simulans proves effective in killing methicillin-resistant Staphylococcus aureus (MRSA) which is endemic in hospitals worldwide. Lss is Zn-dependent endopeptidase, but its bacteriolytic activity could be affected by exogenously added Zn.

Objective: To gain greater insights into structural and functional impacts of Znand Nion Lss-induced bioactivity.

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Gastric cancer (GC) is one of the most common fatal cancers among gastrointestinal malignancies. At present, the treatment of gastric cancer involves a combination of surgery and chemotherapy. Isofebrifugine (IFE) is an alkaloid with many biological properties.

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