Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury mice.

Sodium butyrate (SB) has been widely used to treat cerebral diseases. The aim of the present study is to examine the neuroprotective effects of SB on early TBI in mice and to explore the underlying mechanisms of these effects. TBI was induced using a modified weight-drop method.

Topical application of epidermal growth factor with no scaffold material on the healing of human traumatic tympanic membrane perforations.

Objective: We evaluated the effects of conservative treatment and topical application of epidermal growth factor (EGF) with no scaffold material on the healing of human traumatic tympanic membrane perforations (TMPs).

Study Design: Prospective, randomised clinical trial.

Methods: A prospective analysis was performed between January 2015 and March 2015 for the treatment of human traumatic TMPs.

Risk factors affecting human traumatic tympanic membrane perforation regeneration therapy using fibroblast growth factor-2.

Objective: The use of growth factors to achieve closure of human traumatic tympanic membrane perforations (TMPs) has recently been demonstrated. However, pretreatment factors affecting healing outcomes have seldom been discussed. The objective of this study was to evaluate pretreatment factors contributing to the success or failure of healing of TMPs using fibroblast growth factor-2 (FGF-2).

Utility of basic fibroblast growth factor in the repair of blast-induced total or near-total tympanic membrane perforations: A pilot study.

Objective: A pilot study was performed to investigate the utility of basic fibroblast growth factor (bFGF) in the repair of blast-induced total or near-total tympanic membrane perforations (TMPs).

Study Design: Prospective clinical study.

Setting: Tertiary university hospital.

The protective role of montelukast against intestinal ischemia-reperfusion injury in rats.

Several drugs are effective in attenuating intestinal ischemia-reperfusion injury (IRI); however little is known about the effect of montelukast. Fifty rats were randomly assigned to 3 groups: model group (operation with clamping), sham group (operation without clamping), and study group (operation with clamping and 0.2, 2 and 20 mg/kg montelukast pretreatment).

The effect of ofloxacin otic drops on the regeneration of human traumatic tympanic membrane perforations.

Objective: To investigate the effects of direct application of ofloxacin otic drops on human traumatic tympanic membrane perforations (TMPs).

Study Design: Prospective, sequential allocation, controlled clinical study.

Setting: Tertiary university hospital.

Comparative study on the effects of EGF and bFGF on the healing of human large traumatic perforations of the tympanic membrane.

Objectives/hypothesis: We evaluated the effects of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on the healing of large traumatic tympanic membrane perforations (TMPs).

Study Design: Prospective clinical study.

Setting: Tertiary university hospital.

Evaluation of the optimum time for direct application of fibroblast growth factor to human traumatic tympanic membrane perforations.

Objective: The aim of this study was to determine the optimum time for direct application of basic fibroblast growth factor (bFGF) on large traumatic tympanic membrane perforations (TMPs).

Study Design: Prospective clinical study.

Setting: Tertiary University Hospital.

Effects of basic fibroblast growth factor dose on traumatic tympanic membrane perforation.

Objective: To compare the healing outcomes of higher and lower doses of basic fibroblast growth factor (bFGF) on human traumatic tympanic membrane perforation (TMP).

Study Design: Prospective clinical study.

Methods: All patients with traumatic TMP were treated by direct application of bFGF, and were sequentially allocated into one of two groups: lower-dose group (2-3 drops of bFGF solution daily, approximately 0.

Comparison of the healing mechanisms of human dry and endogenous wet traumatic eardrum perforations.

This prospective study aimed to assess the spontaneous healing mechanisms of human dry and endogenous wet traumatic tympanic membrane perforations (TMPs). A total of 106 patients with traumatic TMPs were included. Based on the presence or absence of endogenous bloody or watery exudates on the residual eardrum and/or at perforation margins, 73 perforations were classified as dry perforations and the remaining 33 as endogenous wet perforations.

Natural evolution of an eardrum bridge in patients with a traumatic eardrum perforation.

Although the "eardrum bridge" of traumatic tympanic membrane perforations (TMPs) is very little seen, the underlying natural evolution during the healing process are still unknown.The aim of this retrospective study was to evaluate the natural evolution of the "eardrum bridge" of TMPs. The data for 36 patients with barotrauma-associated traumatic TMPs with an "eardrum bridge" between January 2006 and December 2007 were retrieved.

Enhancement of invasion of hepatocellular carcinoma cells through lysophosphatidic acid receptor.

Objectives: Lysophosphatidic acid (LPA) is a bioactive lipid mediator involved in tumour progression, cell invasion and metastasis. The mechanism of action of LPA in the invasive and metastatic capacity of human hepatocellular carcinoma (HCC) is not fully understood. This study investigated the effects of LPA on HCC cell invasion and induction of matrix metalloproteinase (MMP) -2 and -9.

Late crust formation as a predictor of healing of traumatic, dry, and minor-sized tympanic membrane perforations.

Objective: The goal of this study was to evaluate the effects of crust formation on the healing of traumatic, dry, and minor-sized tympanic membrane perforations (TMPs) in humans.

Study Design: Case series with a chart review.

Setting: Tertiary university hospital.