Molecular significance of circRNAs in malignant lymphoproliferative disorders: pathogenesis and novel biomarkers or therapeutic targets.

Recent studies have shown that circular RNAs (CircRNAs) have the novel functions and molecular mechanisms in the pathogenesis of malignant diseases. CircRNAs have been found to be associated with the occurrence and development of lymphoproliferative diseases, impacting on lymphocyte proliferation. This article provides a review of the pathogenesis of circRNAs in malignant lymphoproliferative disorders, focusing on conditions such as acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), and lymphoma.

Synthetic ditempolphosphatidylcholine liposome-like nanoparticles for anti-oxidative therapy of atherosclerosis.

Atherosclerosis (AS), a chronic inflammatory disease, is the leading cause of death worldwide. Anti-oxidative therapy has been developed for AS therapy in light of the critical role of ROS in pathogenesis of AS, but current anti-oxidants have exhibited limited outcomes in the clinic. Herein, new ROS-eliminating liposome-like NPs (Tempol-Lips) were assembled from synthetic lipids that covalently conjugated two Tempol molecules with phosphatidylcholine by esterification reaction.

LINC00630 as a miR-409-3p sponge promotes apoptosis and glycolysis of colon carcinoma cells via regulating HK2.

Long-chain non-coding RNAs (lncRNAs) belong to the family of non-coding RNAs and contain more than 200 nucleotides. They are involved in the growth, apoptosis, and glycolysis of carcinoma cells. A newly discovered lncRNA, LINC00630, has been reported in colon carcinoma.

relieves liver injury by regulating immunity and suppression of the enterogenic endotoxin-induced inflammatory response in rats cotreated with alcohol and iron.

Excessive alcohol and iron intake can reportedly cause liver damage. In the present study, we investigated the effect of on liver injury in rats co-exposed to alcohol and iron and evaluated its possible mechanism. Sixty male Wistar rats were randomly divided into three groups for 12 weeks: the Control group (administered normal saline by gavage and provided a normal diet); alcohol +iron group (Model group, treated with alcohol [3.

Follicular dendritic cell sarcoma of the tonsil: case report and review of literature.

Objective: To explore the clinicopathologic features, immunophenotype, differential diagnosis, and prognosis of tonsil follicular dendritic cell sarcoma (FDCS).

Methods: In the Department of Pathology, the affiliated Yantai Yuhuangding Hospital of Qingdao University, in 2019, a case of tonsil FDCS was diagnosed and retrospectively analyzed to summarize its clinical and pathologic characteristics. Relevant literature was reviewed.

Microcystic urothelial carcinoma: a case report.

Microcystic urothelial carcinoma (MUC) is a rare variant of urothelial carcinoma that is highly aggressive with poor prognosis. Due to the scarcity of cases, its histologic morphology and immunohistochemical characteristics are still not clear. This paper reports a 71-year old female patient with gross hematuria and abdominal pain.

Collision tumor of carcinoma and lymphoma in the cecum: case report and review of literature.

Collision tumors that occur in the gastrointestinal tract, especially the intestine, are rare, and collisions of carcinoma and lymphoma are even more rare. We report a case of collision tumor with adenocarcinoma and non-Hodgkin's diffuse large B-cell lymphoma in the cecum of an elderly male patient. Literature was reviewed to explore the clinicopathologic features, differential diagnosis, treatment, and prognosis of collision tumors with carcinoma and lymphoma involving the gastrointestinal tract, to enhance the understanding of this rare tumor, and improve diagnosis and treatment.

The clinicopathological features of combined primary hepatic adenosquamous-hepatocellular carcinoma.

Objective: To explore the pathological features of combined primary hepatic adenosquamous carcinoma (ASC) and hepatocellular carcinoma (HCC).

Methods: The clinicopathological data of one case of cASC-HCC was collected, and the features were analyzed through a literature review.

Results: The male patient was 59 years old and had suffered from inconsistent, upper abdominal pain without any obvious cause for one year.

High-grade serous carcinoma of fallopian tube with yolk sac tumor differentiation in a postmenopausal patient.

Yolk sac tumors (YSTs) are the second most common germ cell malignancy of the ovaries, generally presenting in children and young women. However, they rarely occur in the fallopian tubes of postmenopausal patients. The current rare case is composed of yolk sac tumor differentiation within high-grade serous carcinoma (HGSC) arising in the fallopian tube of a 68-year-old woman.

Mixed malignant peripheral nerve sheath tumor in the inguinal region: a case report.

Malignant peripheral nerve sheath tumor (MPNST) is a rare malignant soft tissue tumor that accounts for approximately 5% of all soft tissue sarcomas. This tumor originates from the peripheral nerves and occurs mainly in the limbs, head and neck, and spine. As a more aggressive tumor, it has higher recurrence and metastasis rates, and patient prognosis is poor.

Three-point sign in subacute combined degeneration of the spinal cord: A case report.

Rationale: Subacute combined degeneration (SCD) of the spinal cord has been reported to have distinctive characteristics on magnetic resonance imaging (MRI), such as an "inverted V sign", a "pair of binoculars sign", and a "dot sign". We report a 3-point sign as a novel MRI characteristic, expanding the spectrum of imaging signs for SCD.

Patient Concerns: A 64-year-old female vegetarian presented with a 3-month history of progressive numbness and weakness in the lower extremities.

Upregulated miR-222 targets BCL2L11 and promotes apoptosis of mesenchymal stem cells in preeclampsia patients in response to severe hypoxia.

Abnormal maternal trophoblast invasion is a common finding in preeclampsia pregnancy. A hypoxic environment develops in the placenta after the 10th week of pregnancy and exerts a major influence over trophoblast activity. In the present study, we investigated expression of miR-222 and apoptosis-related BCL2L11 in preeclampsia placenta and in primary placenta mesenchymal stem cells (MSCs) under hypoxia.

Reduced CRHR-2 in placental tissues is associated with the high DNA methylation of CRHR-2 promoter in idiopathic preterm birth.

The present study was to explore the expression of CRHR-1 and CRHR-2 in the placentas of idiopathic preterm birth (PTB-I), and to identify the and methylation with the deregulated CRHR-1 and CRHR-2. Immunohistochemical staining, real-time quantitative PCR and western blot analysis were performed to examine the expression of CRHR-1 and CRHR-2. The methylation in promoter regions of the and genes were specifically was analyzed using MethyLight method.

-Butylphthalide Improves Cognitive Function in Rats after Carbon Monoxide Poisoning.

Cognitive impairment is the most common neurologic sequelae after carbon monoxide (CO) poisoning, and the previous investigations have demonstrated that -Butylphthalide (NBP) could exert a broad spectrum of neuroprotective properties. The current study aimed to investigate the effect of NBP on cognitive dysfunction in rats after acute severe CO poisoning. Rats were randomly divided into a normal control group, a CO poisoning group and a CO+NBP group.

[The clinical significance of Delphian lymph node metastasis in papillary thyroid cancer].

To evaluate the clinical significance of Delphian lymph node (DLN) metastasis in papillary thyroid cancer (PTC). A total of 505 cases with PTC confirmed pathologically in our hospital between January 2015 and December 2015 were retrospectively reviewed. 208 patients with DLN assessed separately by histopathologic examination who underwent primary surgery for PTC were included for the following analysis.

-Butylphthalide Alleviates Blood-Brain Barrier Impairment in Rats Exposed to Carbon Monoxide.

Carbon monoxide (CO) poisoning is one of the most important health concerns and may result in neuropathologic changes and neurologic sequelae. However, few studies have addressed the correlation between CO poisoning and blood-brain barrier (BBB) impairment. In this study, we investigated the effects of -butylphthalide (NBP) on the expressions of zonula occludens-1 (ZO-1), claudin-5 and aquaporin-4 (AQP-4) proteins in a CO poisoning rat model.