4 results match your criteria: "The Affiliated Stomatology Hospital of Guizhou Medical University[Affiliation]"
SIRT7 inhibits the aging and inflammatory damage of hPDLFs by suppressing the AKT/mTOR.
Int Immunopharmacol
December 2024
School of Stomatology, Guizhou Medical University, Guiyang 550004, Guizhou Province, PR China; Department of Prosthodontics, The Affiliated Stomatology Hospital of Guizhou Medical University, Guiyang 550004, Guizhou Province, PR China. Electronic address:
Article Synopsis
- Periodontitis is a global oral health issue that hasn’t seen a decline despite prevention efforts, potentially linked to DNA damage-induced cellular senescence.
- SIRT7, an important protein with deacetylase activity, is found to be downregulated in human periodontal ligament fibroblasts when exposed to inflammatory bacteria, which leads to increased senescence and inflammation.
- Overexpression of the SIRT7 gene inhibits the production of related senescence molecules and inflammatory cytokines, suggesting that targeting SIRT7 could be a promising approach for treating periodontitis.
LncRNA HOTTIP facilitates osteogenic differentiation in bone marrow mesenchymal stem cells and induces angiogenesis via interacting with TAF15 to stabilize DLX2.
Exp Cell Res
August 2022
Department of Pathology and Pathophysiology, School of Basic Medicine, Guizhou Medical University, Guiyang, 550002, Guizhou Province, PR China; Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, Guizhou Province, PR China. Electronic address:
Aim: The molecular mechanism of differentiation in bone marrow mesenchymal stem cells (BMSCs) preserves to be further elucidated. LncRNA HOTTIP has been proven to accelerate osteogenic differentiation, but the regulation mechanism is still unclear.
Methods: The human BMSCs (hBMSCs) were isolated and identified by the antigen CD29, CD34, CD44, CD45, and CD90 through flow cytometry.
DLX2 activates Wnt1 transcription and mediates Wnt/β-catenin signal to promote osteogenic differentiation of hBMSCs.
Gene
June 2020
Guizhou University of Traditional Chinese Medicine, Guiyang 550025, PR China. Electronic address:
Objectives: The molocular mechanism underlying human bone marrow mesenchymal stem cells (hBMSCs) differentiation remains to be further elucidated. DLX2 has been confirmed to accelerate osteogenic differentiation which is one member of Distal-less family genes. However, how DLX2 regulates in osteogenic differentiation is still unclear.
View Article and Find Full Text PDF[The expression and significance of S100A9 in oral squamous cell carcinoma].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
February 2017
Oral and Maxillofacial Surgery of the Affiliated Stomatology Hospital of Guizhou Medical University, Guiyang, 550004, China.
This research intended to explore the expression levels of S100A9 protein in oral squamous cell carcinoma (OSCC), and to analyze its relation with clinicopathologic features in OSCC, then discuss its clinical significance in diagnosis and prognosis of OSCC. Using immunohistochemistry and Western blot to examine S100A9 in 35 oral squamous cell carcinoma specimen and 30 normal oral tissue as control.Expression of S100A9 in oral squamous cell carcinoma (77.
View Article and Find Full Text PDF