1 results match your criteria: "The Affiliated Nanjing Children's Hospital of Nanjing Medical University Nanjing 210008[Affiliation]"
CCND1 G870A polymorphism is associated with toxicity of methotrexate in childhood acute lymphoblastic leukemia.
Int J Clin Exp Pathol
December 2016
Department of Hematology and Oncology, The Affiliated Nanjing Children's Hospital of Nanjing Medical University Nanjing 210008, China.
CCND1 plays a key role in cell cycle progression and may cause methotrexate (MTX) resistance, as well as its cytotoxicity. CCND1 870A variant allele is associated with altered transcripts of this gene. We hypothesized that this polymorphism may contribute to the elimination rate and hepatotoxicity of MTX in childhood acute lymphoblastic leukemia (ALL).
View Article and Find Full Text PDF