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Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model.
Nanoscale Adv
January 2023
Department of Dermatology, The Affiliated Jiangning Hospital with Nanjing Medical University Nanjing 211100 China
Article Synopsis
- Microneedle technology is effective in reducing hypertrophic scarring in both animals and humans by utilizing physical contact inhibition.
- The study focuses on the impact of different microneedle materials on scar formation, specifically using a rabbit ear hypertrophic scar model over 42 days.
- Among various materials tested, polymethylmethacrylate microneedles showed the best results in lowering tissue fibrosis and expressions of key proteins and mRNA, while other materials like polycarbonates and polyurethanes also suppressed certain biomarker expressions but were less effective overall.