295 results match your criteria: "The Affiliated Hospital to Changchun University of Chinese Medicine[Affiliation]"
BMC Palliat Care
December 2024
Alexander Hospital of National University Hospital System, Singapore, Singapore.
Background: In the current era of rapid technological development, digital technology is progressively transforming the medical field. In palliative care, its integration is an inevitable trend, offering new possibilities for improving care delivery and patient outcomes.
Objective: This study aimed to review the application of digital technologies in palliative care, focusing on their advantages, challenges, and measurable impacts across diverse care settings.
Tissue Cell
November 2024
Children's Diagnosis and Treatment Center, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun City, Jilin Province 130000, PR China. Electronic address:
Asthma is a prevalent chronic pediatric lung disease which is commonly perceived as a syndrome of airway inflammation characterized by cough and wheeze in clinic. Klotho is implicated in diverse cellular activities, including inflammation, oxidative stress and apoptosis. This paper aims to explore the role of klotho in asthma and investigate the relevant molecular reaction mechanisms.
View Article and Find Full Text PDFRegen Ther
June 2024
Department of Nephrology, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, China.
Kidney stones are a foremost clinical concern in urology with CaOx crystals accounting for roughly 80% of these renal formations. This research endeavor seeks to ascertain the protective effects of Metformin-encapsulated selenium nanoparticles (M@Se NPs), combined with a 55% hydroethanolic flower extract from () in countering the formation of kidney stones in Male Sprague Dawley rats. The particle's diameter was measured to be 39 nm and 13.
View Article and Find Full Text PDFMedicine (Baltimore)
December 2024
The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin Province, China.
Myocardial infarction, a type of coronary artery disease, results from various factors such as genetic predisposition, lifestyle choices, and immune system regulation. The exact causal links between immune cells, plasma metabolites, and myocardial infarction are currently unclear. Therefore, our study employed the Mendelian randomization approach to explore these potential causal relationships.
View Article and Find Full Text PDFACS Omega
December 2024
Gastroenteric Medicine and Digestive Endoscopy Center, The Second Hospital of Jilin University, Changchun, Jilin Province 130041, China.
Antibody-based tumor-targeting nanomedicines, despite their high efficacy, present significant challenges in preparation and long-term storage. We introduce a novel approach for the synthesis of durable, ready-to-use, antibody-coupled nanomedical drugs. Our research centers on the development of HER2-targeting DM1-loaded nanoparticles for gastric cancer treatment using a modular methodology.
View Article and Find Full Text PDFJ Cell Mol Med
December 2024
Department of Gynaecology, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin, China.
Endometritis is one of the common reproductive diseases in human and animal. In recent years, a number of studies have found that Schisandra B (Sch B), as a natural Chinese medicine extract, has antioxidant, anti-inflammatory and other biological activities. Based on the above, in this study, mice were used to conduct an in vivo experiment to investigate the effect and mechanism of Sch B on lipopolysaccharide (LPS)-induced endometritis.
View Article and Find Full Text PDFHeliyon
October 2024
Precision Medicine Center, Jilin Province People's Hospital, Changchun, Jilin, 130021, China.
Oxidative stress is closely associated with the estimated glomerular filtration rate (eGFR) levels. A comprehensive indicator for evaluating dietary and lifestyle exposures to oxidative stress is the Oxidative Balance Score (OBS), with higher OBS suggesting more substantial antioxidant exposures. The aim of this study is to explore the relationship between OBS and eGFR levels.
View Article and Find Full Text PDFJ Asthma
December 2024
Department of Respiratory, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China.
Background: Neuroticism has been associated with asthma, but the nature of this relationship remains unclear due to limited understanding of the impact of psychological factors on asthma risk. While Neuroticism is known to affect various health outcomes, its specific role in respiratory conditions like asthma is not fully understood.
Methods: We conducted Mendelian randomization (MR) analyses using genome-wide association studies (GWAS) to explore the causal link between 12 Neuroticism traits and asthma.
J Tradit Chin Med
December 2024
Department of Pediatrics, the Affiliated hospital to Changchun University of Chinese Medicine, Changchun 130017, China.
Objective: To investigate the effect of baijinpingchuan (, BJPC) on the asthma rat model and identify differential metabolites and disturbed metabolic pathways.
Methods: The rats were categorized into six groups: control, dexamethasone (DEX), ovalbumin (OVA), and low-, median-, and high-dose BJPC. The rats, except for the control group, were initially treated with OVA to develop the asthma model, which was then activated using DEX, OVA, and low-, median-, and high-dose BJPC.
Biochem Biophys Rep
December 2024
Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Yin deficiency syndrome is a theoretical concept of traditional Chinese medicine (TCM) that claims an imbalance between Yin and Yang serves as a potential etiological factor disrupting physiological homeostasis. Its diagnosis in TCM is hindered by the intricate and diverse etiology, resulting in the absence of quantification and standardization. Hence, this study developed a hydrocortisone (HC) induced Yin deficiency syndrome model to investigate the intricate network underlying TCM and elucidate its intervention mechanism.
View Article and Find Full Text PDFMol Cell Biochem
November 2024
Department of Cardiology, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, 130021, China.
Coronary artery disease, atherosclerosis, and its life-threatening sequels impose the hugest burden on the healthcare systems throughout the world. The intricate process of atherosclerosis is considered as an inflammatory-based disorder, and therefore, the components of the immune system are involved in different stages from formation of coronary plaques to its development. One of the major effectors in this way are the antibody producing entities, the B cells.
View Article and Find Full Text PDFNat Prod Res
November 2024
College of Pharmacy, Changchun University of Chinese Medicine, Changchun, China.
American ginseng( L.), a traditional herbal extensively utilised in China, exhibits both medicinal and food properties. Diverse processing American ginseng gain extensive utilisation in China.
View Article and Find Full Text PDFJ Med Internet Res
November 2024
Center of Children's Clinic, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China.
Background: Kawasaki disease (KD) is an acute pediatric vasculitis that can lead to coronary artery aneurysms and severe cardiovascular complications, often presenting with obvious fever in the early stages. In current clinical practice, distinguishing KD from other febrile illnesses remains a significant challenge. In recent years, some researchers have explored the potential of machine learning (ML) methods for the differential diagnosis of KD versus other febrile illnesses, as well as for predicting coronary artery lesions (CALs) in people with KD.
View Article and Find Full Text PDFFront Pharmacol
October 2024
Department of Encephalopathy, The Affiliated Hospital of Changchun University of Chinese Medicine, Jilin, China.
Introduction: Ferroptosis is a crucial process contributing to neuronal damage following intracerebral hemorrhage (ICH). Didang Tang (DDT), a traditional therapeutic, has been used clinically to manage ICH for many years, yet the molecular mechanisms by which by DDT protects neurons from ferroptosis after ICH remain elusive.
Methods: This study utilized high-performance liquid chromatography-based fingerprint analysis to characterize DDT's chemical composition.
Int J Mol Med
January 2025
Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130021, P.R. China.
Ginseng may improve the myelosuppression and intestinal microbiota disorder induced by cyclophosphamide (CY); however, the effect of ginseng components on hematopoietic stem cell (HSC) damage remains largely unexplored. The present study aimed to assess the protective effect of ginseng extract (GE), total ginsenosides (TG) and total polysaccharides (TP) from ginseng on the intestinal microflora and HSCs of model mice. In the present study, a mouse model of HSC damage induced by CY was constructed, intestinal microflora of fecal samples were sequenced using the 16S ribosomal RNA (rRNA) sequencing techniques, the differentially expressed genes (DEGs) of HSCs were analyzed using high‑throughput RNA‑sequencing, cell apoptosis and erythroid differentiation were detected using flow cytometry and the blood cell parameters were analyzed using a hematology analyzer.
View Article and Find Full Text PDFBMC Pediatr
November 2024
Department of Pediatrics, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, 130022, China.
Objective: This study aimed to investigate the relationship between serum lactate levels at admission to the intensive care unit (ICU) and the clinical outcomes of children with sepsis.
Methods: We used the Pediatric Intensive Care (PIC) database to identify 288 pediatric patients with sepsis. We analyzed the relationship between lactate levels and hospital and ICU mortality in sepsis by establishing a segmented multivariable Cox regression model.
Front Cardiovasc Med
October 2024
College of Integrative Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Objectives: There is limited amount of research on the association between fecal incontinence (FI) and cardiovascular disease (CVD). This study aims to evaluate whether there is a relationship between FI and CVD among adults in the United States.
Methods: This study employed a cross-sectional design, encompassing 11,237 adults aged 20 years and older, drawn from the National Health and Nutrition Survey conducted from 2005 to 2010.
Neurochem Int
December 2024
Department of Anatomy, Histology and Embryology, K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. Electronic address:
Capsaicin activates primary afferent transient receptor potential vanilloid 1 (TRPV1) in the spinal dorsal horn and induces exaggerated glutamate release. This capsaicin action is followed by a lasting refractory state referred to as "capsaicin desensitization", which is considered a presynaptic event. In this study, using whole-cell recordings and holographic photostimulation, we reassessed this notion by investigating presynaptic glutamate release and the postsynaptic glutamate response during capsaicin administration.
View Article and Find Full Text PDFFront Med (Lausanne)
October 2024
Fangzheng Research Laboratory, Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, China.
Background: Rheumatoid arthritis (RA) is a widespread chronic autoimmune disease that primarily causes joint inflammation and damage. In advanced stages, RA can result in joint deformities and loss of function, severely impacting patients' quality of life. The "Tianyu" pair (TYP) is a traditional Chinese medicine formulation developed from clinical experience and has shown some effectiveness in treating RA.
View Article and Find Full Text PDFBiochimie
October 2024
Changchun University of Chinese Medicine, Changchun, 130117, China.
Front Cell Infect Microbiol
October 2024
The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China.
Parkinson's disease (PD) is a neurodegenerative disorder that significantly impacts patients' quality of life. Recent evidence has highlighted a complex relationship between the gut microbiota (GM) and PD. Understanding this relationship is crucial for potentially targeting GM in PD treatment and expanding therapeutic options.
View Article and Find Full Text PDFBiomol Biomed
October 2024
Department of Encephalopathy, The Affiliated Hospital to Changchun University of Chinese Medicine, Jilin, Changchun, China.
J Appl Microbiol
October 2024
Children's Diagnosis and Treatment Center, The Affiliated Hospital to Changchun University of Chinese Medicine, No. 185, Shenzhen Street, Nanguan District, Changchun, Jilin 130022, China.
J Ethnopharmacol
January 2025
College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, PR China; Center of Children's Clinic, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, 130022, PR China. Electronic address:
Endocr Metab Immune Disord Drug Targets
October 2024
Department of Prevention and Treatment of Disease Care Center, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, 130000, China.