9 results match your criteria: "The Affiliated Hospital of Guiyang Medical University[Affiliation]"
Article Synopsis
- CSF1 is usually produced by immune cells to help regulate macrophage function, particularly in maintaining intestinal health, and is important in understanding necrotizing enterocolitis (NEC) in newborns.
- In a study, researchers found that CSF1 expression in the intestines of infants with NEC was reduced, and the presence of CSF1R macrophages diminished in affected tissues, indicating their role in intestinal inflammation.
- The findings suggest that while CSF1 helps support normal intestinal function and macrophage activity, its downregulation during inflammation (like in NEC) can lead to immune dysfunction and tissue damage.
Opportunistic Screening Using Low-Dose CT and the Prevalence of Osteoporosis in China: A Nationwide, Multicenter Study.
J Bone Miner Res
March 2021
Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing, China.
Opportunistic screening for osteoporosis can be performed using low-dose computed tomography (LDCT) imaging obtained for other clinical indications. In this study we explored the CT-derived bone mineral density (BMD) and prevalence of osteoporosis from thoracic LDCT in a large population cohort of Chinese men and women. A total of 69,095 adults (40,733 men and 28,362 women) received a thoracic LDCT scan for the purpose of lung cancer screening between 2018 and 2019, and data were obtained for analysis from the China Biobank Project, a prospective nationwide multicenter population study.
View Article and Find Full Text PDFFlurbiprofen Inhibits Androgen Productions in Rat Immature Leydig Cells.
Chem Res Toxicol
August 2019
Department of Anesthesiology , The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou , Zhejiang 325027 , People's Republic of China.
Flurbiprofen is one of the nonsteroidal anti-inflammatory drugs. Whether flurbiprofen affects androgen biosynthesis in Leydig cells is still unknown. Immature Leydig cells (ILCs) isolated from 35-day-old male Sprague-Dawley rats were cultured with 0-100 μM flurbiprofen for 24 h and medium androgen levels and Leydig cell mRNA levels were measured.
View Article and Find Full Text PDFRemission assessment of rheumatoid arthritis in daily practice in China: a cross-sectional observational study.
Clin Rheumatol
March 2018
Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
The objective of this study is to evaluate the remission rate and describe the current use of medication in a large cohort of rheumatoid arthritis (RA) patients under routine clinical care in China. RA patients were recruited from 40 large teaching hospitals nationwide in China. Data regarding RA disease activity, medication treatment, and adverse events were recorded using a standardized clinical data questionnaire.
View Article and Find Full Text PDFMicroRNA-605 functions as a tumor suppressor by targeting INPP4B in melanoma.
Oncol Rep
August 2017
Department of Dermatology, The Affiliated Hospital of Guiyang Medical University, Yunyan, Guiyang, Guizhou 550004, P.R. China.
Article Synopsis
- MicroRNAs, specifically miR-605, are implicated in the development and progression of melanoma, with its downregulation observed in both melanoma cell lines and clinical samples.
- Functional studies show that miR-605 inhibits melanoma cell growth by targeting the INPP4B gene, which is linked to SGK3 activation.
- These findings suggest that miR-605 acts as a tumor suppressor in melanoma and could be a promising target for future cancer therapies.
Cul1 promotes melanoma cell proliferation by promoting DEPTOR degradation and enhancing cap-dependent translation.
Oncol Rep
February 2016
Department of Dermatology, The Affiliated Hospital of Guiyang Medical University, Guiyang, Guizhou 550004, P.R. China.
Cullin1 (Cul1) serves as a rigid scaffold in the SCF (Skp1/Cullin/Rbx1/F-box protein) E3 ubiquitin ligase complex and has been found to be overexpressed in melanoma and to enhance melanoma cell proliferation by promoting G1-S phase transition. However, the underlying mechanisms involved in the regulation of melanoma cell proliferation by Cul1 remain poorly understood. In the present study, we found that Cul1 promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR.
View Article and Find Full Text PDFExpression and clinicopathological significance of CD9 in gastrointestinal stromal tumor.
J Korean Med Sci
October 2013
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. ; Department of Gastrointestinal Surgery of the Affiliated Hospital of Guiyang Medical University, Guiyang, Guizhou Province, China.
This study investigated the expression and clinicopathological significance of CD9 in gastrointestinal stromal tumor (GIST). Immunohistochemistry staining for CD9 was performed on tumor tissues from 74 GIST patients. The correlation with clinicopathological features, risk classification and prognosis was analyzed.
View Article and Find Full Text PDF[Prospective observational study exploring the relationship between the levels and variability of blood glucose and the prognosis of critical patients].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
September 2012
Department of Critical Care Medicine, the Affiliated Hospital of Guiyang Medical University, Guiyang 550004, Guizhou, China.
Objective: To explore the relationship between the levels and variability of blood glucose and the prognosis of critical patients.
Methods: A prospective study was conducted. Blood glucose monitoring and prognosis observation were performed for the adult nondiabetic patients admitted in intensive care unit (ICU) from June 2011 to January 2012.
[Analysis for myeloperoxidase genetic polymorphism in gastric cancer].
Zhonghua Wei Chang Wai Ke Za Zhi
July 2011
Department of Gastrointestinal Surgery, The Affiliated Hospital of Guiyang Medical University, Guiyang 550004, China.
Objective: To investigate the association of myeloperoxidase(MPO) genetic polymorphism and gastric cancer.
Methods: A case-control study was performed including 62 patients with gastric cancer and 61 healthy controls. Peripheral blood was collected for genetic analysis of MPO-463.