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Single-cell transcriptomics reveals writers of RNA modification-mediated immune microenvironment and cardiac resident Macro-MYL2 macrophages in heart failure.
BMC Cardiovasc Disord
August 2024
First Department of Cardiology, The Affiliated Guangdong Second Provincial General Hospi-tal of Jinan University, NO. 466, Xingang Middle Road, Haizhu District, Guangzhou City, China.
Background: Heart failure (HF), which is caused by cardiac overload and injury, is linked to significant mortality. Writers of RNA modification (WRMs) play a crucial role in the regulation of epigenetic processes involved in immune response and cardiovascular disease. However, the potential roles of these writers in the immunological milieu of HF remain unknown.
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