43 results match your criteria: "The Affiliated Foshan Hospital of Sun Yat-sen University[Affiliation]"
Cell Death Dis
September 2020
Department of Hematology, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, Guangdong, China.
Acute myeloid leukemia (AML) is a heterogeneous myeloid neoplasm with poor clinical outcome, despite the great progress in treatment in recent years. The selective Bcl-2 inhibitor venetoclax (ABT-199) in combination therapy has been approved for the treatment of newly diagnosed AML patients who are ineligible for intensive chemotherapy, but resistance can be acquired through the upregulation of alternative antiapoptotic proteins. Here, we reported that a newly emerged histone deacetylase inhibitor, chidamide (CS055), at low-cytotoxicity dose enhanced the anti-AML activity of ABT-199, while sparing normal hematopoietic progenitor cells.
View Article and Find Full Text PDFCase Rep Gastroenterol
February 2020
Department of Hepatic Surgery, the Affiliated Foshan Hospital of Sun Yat-sen University, Foshan, China.
Situs inversus totalis (SIT) is a rare congenital condition in which the usual position of the organs is reversed from left to right as a mirror image of the normal situation. Due to the abnormal transposition, this represents a technical challenge for the surgeon. In the present study, right hemihepatectomy via the anterior approach was performed for a 68-year-old hepatocellular carcinoma (HCC) patient with SIT.
View Article and Find Full Text PDFJ Endocrinol Invest
September 2020
Division of Interventional Ultrasound, Department of Medical Ultrasound, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.
Purpose: To retrospectively evaluate the clinical outcomes of percutaneous ultrasound (US)-guided radiofrequency ablation (RFA) in treatment of adrenal metastasis (AM), and to compare with adrenalectomy (Adx).
Methods: From June 2008 to August 2018, a total of 60 patients with AM treated at our hospital were retrospectively reviewed, of whom 29 treated by RFA (RFA group) and 31 by Adx (Adx group). The technical success, local tumor progression (LTP) and overall survival (OS) after the treatment were evaluated and compared.
Med Oncol
March 2020
Department of Infectious Disease, The Third Affiliated Hospital of Sun Yat-Sen University, No.600 Tianhe Road, Tianhe District, Guangzhou, 510630, China.
Lenvatinib is a long-awaited alternative to sorafenib for the first-line targeted therapy of patients with advanced hepatocellular carcinoma (HCC). However, resistance to lenvatinib has also become a major obstacle to improving the prognosis of HCC patients. The underlying molecular mechanisms contributing to lenvatinib resistance in HCC are largely unknown.
View Article and Find Full Text PDFInt J Hyperthermia
October 2020
Division of Interventional Ultrasound, Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
To summarize the published literature on thermal ablation for primary hyperparathyroidism (PHPT) and to evaluate the effectiveness and safety of thermal ablation as a novel treatment strategy. Two authors carried out the literature search using four databases independently, including PubMed, Embase, Cochrane, and Web of Science. The meta-analysis included prospective and retrospective data that compared post-ablative outcomes to pre-ablative values.
View Article and Find Full Text PDFTransl Cancer Res
March 2020
Department of Hepatic Surgery, the First People's Hospital of Foshan, the Affiliated Foshan Hospital of Sun Yat-sen University, Foshan 528000, China.
Background: Chaperonin containing TCP1 subunits (CCTs) are important components in the folding of newly synthesized proteins and are involved in cell growth, proliferation, and apoptosis in eukaryotes. Accumulating evidence indicates that dysregulation of CCTs is involved in tumorigenesis. However, the roles of distinct CCTs in the occurrence and development of hepatocellular carcinoma (HCC) are largely unknown.
View Article and Find Full Text PDFCancer Lett
October 2019
Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China. Electronic address:
Leukemia stem cells (LSCs) are deemed to the mainspring for treatment failure in acute myeloid leukemia (AML). Conventional chemotherapeutic drugs fail to eradicate leukemia stem cells, which becomes the root of drug resistance and disease recurrence. Hence, new therapeutic strategies targeting LSCs are supposed to be critical for patients with AML.
View Article and Find Full Text PDFMedicine (Baltimore)
June 2019
Department of General Medicine, The First People's Hospital of Foshan (The Affiliated Foshan Hospital of Sun Yat-sen University), Foshan, Guangdong, China.
Rationale: Acute cerebral infarction after snake bites is rare. The underlying mechanism causing the thrombotic process remains complex and unknown.
Patient Concerns: We herein describe a 49-year-old female who was bitten by a Trimeresurus stejnegeri.
Eur J Pharmacol
July 2019
Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, 361003, PR China. Electronic address:
Acute myeloid leukemia (AML) is a heterogeneous malignancy of hematopoietic stem cells with poor clinical outcome despite recent improvements in chemotherapy and stem cell transplantation regimens. Thus, new therapeutic agents are urgently needed in order to prolong the disease-free survival of AML patients in clinic. Here, we report that BBI608 is highly active against diverse AML cell lines in vitro and primary samples obtained from patients with AML ex vivo, as well as effective in vivo in AML xenograft models.
View Article and Find Full Text PDFMedicine (Baltimore)
May 2019
Department of Hepatopancreatic Surgery.
Rationale: Hepatocellular carcinoma (HCC) metastases to the zygomatic bone are extremely uncommon, and the treatment of target drugs against such case is unknown.
Patient Concerns: A 48-year-old male patient was admitted to our hospital under suspicion of an advanced liver tumor due to an increase in levels of alpha-fetoprotein (AFP) after radiofrequency ablation for independent nodule in his liver 1 month before. He had a hepatitis B virus (HBV) history for 20 years without treatment.
Medicine (Baltimore)
August 2018
Department of Hepatopancreatic Surgery, The First People's Hospital of Foshan, the Affiliated Foshan Hospital of Sun Yat-Sen University, Guangdong, China.
Rationale: Ectopic variceal bleeding due to hepaticojejunostomy (HJ) is unusual and difficult to manage. Reports on the use of side-to-side splenorenal shunt for severe bleeding from varices at HJ anastomosis are lacking.
Patient Concerns: A 43-year-old man was admitted to our hospital with repeated episodes of hematemesis.
Knee Surg Sports Traumatol Arthrosc
January 2019
The Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People's Republic of China.
Purpose: This study compared the diagnostic accuracy of second-look arthroscopy, clinical assessment, and magnetic resonance imaging (MRI) in evaluating meniscal healing following repair. To explore the application of 3D-MRI sequences with signal-to-noise ratio (SNR) measurements and the analysis of sensitivity and accuracy in evaluating meniscal healing status after meniscal repair.
Methods: This study included 75 patients (75 menisci; mean age, 25.
J Cancer
September 2017
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou.
Given recent results indicating that diminished LKB1 expression in laryngeal cancer correlates with shorter survival. We aim to perform an analysis estimate the role of decreased liver kinase B1(LKB1) and in the prognostication of human laryngeal squamous cell carcinoma (LSCC). We conducted a retrospective study and evaluate the expression of LKB1 and p16INK4a (p16) in 208 clinical advanced-stage LSCC tissue samples by using immunohistochemistry.
View Article and Find Full Text PDFJ Am Heart Assoc
October 2017
Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
Background: Obesity is a risk factor for many diseases. However, the potential association between adiposity and cognitive decline in hypertensive patients is inconclusive. We performed a secondary data analysis of the CSPPT (China Stroke Primary Prevention Trial) to examine whether adiposity is correlated with longitudinal cognitive performance in hypertensive adults.
View Article and Find Full Text PDFJ Cancer
July 2017
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou.
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is known to function in several types of cancer. In this study, we investigated the expression and clinicopathologic significance of DNA-PKcs in laryngeal squamous cell carcinoma (LSCC). We conducted a retrospective study of 208 patients with advanced-stage LSCC treated at Sun Yat-sen University Cancer Center, Guangzhou, China.
View Article and Find Full Text PDFExp Ther Med
October 2015
Department of Plastic Surgery, The Affiliated Foshan Hospital of Sun Yat-sen University, Foshan, Guangdong 528000, P.R. China.
Marjolin's ulcers, which are epidermoid carcinomas arising on non-healing scar tissue, may be of various pathological types, including squamous cell carcinoma. The pathogenesis of squamous cell carcinoma arising in an ulcer differs from that of the primary cutaneous squamous cell carcinoma. This squamous cell carcinoma is aggressive in nature, and has a high rate of metastasis.
View Article and Find Full Text PDFClin Radiol
December 2014
Minimally Invasive Interventional Division, Medical Imaging Center, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China. Electronic address:
Aim: To evaluate the safety and efficacy of combined therapy with transarterial chemoembolization (TACE) and sorafenib for hepatocellular carcinoma (HCC) with portal venous tumour thrombus (PVTT).
Materials And Methods: This study was approved by the institutional review board. From May 2009 to May 2012, 170 consecutive patients were newly diagnosed with advanced-stage HCC and treated with TACE plus sorafenib.
World J Gastroenterol
April 2009
Department of Hepatobiliary Surgery, the Affiliated Foshan Hospital of Sun Yat-Sen University, Foshan, Guangdong Province, China.
Aim: To explore the feasibility of passage of bone-marrow-derived liver stem cells (BDLSCs) in culture systems that contain cholestatic serum.
Methods: Whole bone marrow cells of rats were purified with conditioning selection media that contained 50 mL/L cholestatic serum. The selected BDLSCs were grown in a proliferating culture system and a differentiating culture system.