The relationship between negative emotions and adjustment disorder in young adults: the mediating role of rumination and insomnia.

Introduction: This study aimed to investigate the influence of negative emotions on adjustment disorder (AjD) in young adults, focusing on the mediating role of rumination and insomnia.

Methods: The study recruited 2015 young patients (aged 18-35) receiving treatment at the Psychosomatic Medicine Department of the Affiliated Encephalopathy Hospital of Zhengzhou University from February 2023 to March 2024. Participants completed the Depression Anxiety and Stress Scale (DASS), Ruminative Responses Scale (RRS), Insomnia Severity Scale (ISI), and Adjustment Disorder - New Module 20(ADNM-20) to assess negative emotions, rumination thinking, sleep status, and AjD.

Metabolic pathway modulation by olanzapine: Multitarget approach for treating violent aggression in patients with schizophrenia.

Background: The use of network pharmacology and blood metabolomics to study the pathogenesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment plans.

Aim: To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent aggression.

Methods: Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment, and the related metabolic pathways were identified.

Refining antipsychotic treatment strategies in schizophrenia: discovery of genetic biomarkers for enhanced drug response prediction.

Schizophrenia (SCZ) is a severe mental disorder affecting around 1% of individuals worldwide. The variability in response to antipsychotic drugs (APDs) among SCZ patients presents a significant challenge for clinicians in determining the most effective medication. In this study, we investigated the biological markers and established a predictive model for APD response based on a large-scale genome-wide association study using 3269 Chinese schizophrenia patients.