Efficacy and safety of once-weekly semaglutide 2.4 mg for weight management in participants from China: A prespecified analysis of the STEP 7 randomized clinical trial.

Aim: To evaluate the efficacy and safety of semaglutide 2.4 mg versus placebo for weight management in a population of Chinese adults with overweight or obesity.

Materials And Methods: In STEP 7 (NCT04251156), a double-blind, phase 3a trial, adults from a predominantly East Asian population with overweight or obesity, with or without type 2 diabetes, were randomized 2:1 to once-weekly subcutaneous semaglutide 2.

tRF-Pro-CGG Suppresses Cell Proliferation and Promotes Apoptosis in Pancreatic Cancer.

Objective: This study aimed to investigate the role of tRNA-derived RNA fragment tRF-Pro-CGG in pancreatic cancer (PC), focusing on its expression levels in PC tissues and cell lines, and its effects on cell proliferation, clonality, migration, invasion, and apoptosis. Additionally, the study explored the potential of tRF-Pro-CGG as a diagnostic biomarker and therapeutic target in PC.

Methods: The expression levels of tRF-Pro-CGG in PC tissues and cell lines were analyzed using next-generation sequencing and quantitative real-time PCR (qRT-PCR).

H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition in airway epithelial cells.

Silica exposure-induced airway epithelial-mesenchymal transition (EMT) is a critical pathological process in pulmonary fibrosis. This study investigated the role of NLRP3 inflammasome, glycolysis, and histone lactylation in silica-induced EMT of human bronchial epithelial cells (16HBE). Silica exposure activated NLRP3 inflammasome, enhanced glycolysis and H3K18 lactylation, as well as induced EMT in 16HBE cells.

Non-differential gut microbes contribute to hypertension and its severity through co-abundances: A multi-regional prospective cohort study.

Microbial dysbiosis, characterized by an imbalanced microbial community structure and function, has been linked to hypertension. While prior research has primarily focused on differential abundances, our study highlights the role of non-differential microbes in hypertension. We propose that non-differential microbes contribute to hypertension through their ecological interactions, as defined by co-abundances (pairs of microbes exhibiting correlated abundance patterns).

Cardiac computed tomography-derived coronary artery volume to myocardial mass for the prediction of risk stratification for acute coronary syndrome.

Purpose: The study aimed to assess various characteristics of coronary computed tomography angiography (CCTA) in patients presenting with suspected coronary artery disease (CAD). Additionally, the research sought to investigate the predictive value of the coronary artery volume to myocardial mass (V/M) derived from CCTA in risk stratification for patients with acute coronary syndrome (ACS) and to determine the relationship between the V/M ratio and the Global Registry of Acute Coronary Events (GRACE) risk score in ACS.

Methods: This was a single-center, retrospective study.

[Analysis of Gene Mutation in Patients with Chronic Myelomonocytic Leukemia].

Objective: To characterize the occurrence of mutations in chronic myelomonocytic leukemia(CMML) patients and their correlation with other gene mutations and some clinical characteristics.

Methods: The clinical data of 43 CMML patients diagnosed in Changzhou No.2 People's Hospital and Wuxi No.

Integration of multiple machine learning approaches develops a gene mutation-based classifier for accurate immunotherapy outcomes.

In addition to traditional biomarkers like PD-(L)1 expression and tumor mutation burden (TMB), more reliable methods for predicting immune checkpoint blockade (ICB) response in cancer patients are urgently needed. This study utilized multiple machine learning approaches on nonsynonymous mutations to identify key mutations that are most significantly correlated to ICB response. We proposed a classifier, Gene mutation-based Predictive Signature (GPS), to categorize patients based on their predicted response and clinical outcomes post-ICB therapy.

Efficacy and safety of ongericimab in Chinese patients with heterozygous familial hypercholesterolemia: A randomized, double-blind, placebo-controlled phase 3 trial.

Background And Aims: Heterozygous familial hypercholesterolemia (HeFH) is a prevalent autosomal dominant disorder of lipid metabolism but severely underdiagnosed and undertreated in China. This phase 3 trial aims to evaluate the efficacy and safety of ongericimab, a novel monoclonal antibody that targets proprotein convertase subtilisin/kexin type 9 (PCSK9), in Chinese patients with HeFH.

Methods: Patients who have been diagnosed with definite HeFH according to Dutch Lipid Clinical Network criteria and receiving stable and optimized lipid-lowering therapy were enrolled.

Mucous Permeable Nanoparticle for Inducing Cuproptosis-Like Death In Broad-Spectrum Bacteria for Nebulized Treatment of Acute Pneumonia.

The emergence of antibiotic-resistant bacteria has exacerbated the challenge of treating infectious diseases. Quorum sensing (QS), a bacterial communication system regulating virulence and biofilm formation, presents a target for novel therapies. Cuproptosis death is a innovation mode of death, however, this effect may be partially inhibited by glutathione (GSH).

Association between gallbladder disease and colorectal neoplasia: a meta-analysis.

Although studies are available on the impact of gallbladder disease on the risk of colorectal neoplasia (CRN), the results are still debatable. We conducted a meta-analysis to summarize the correlation between gallbladder diseases and CRN. Eligible studies up to June 2024 were screened and retrieved using PubMed and Web of Science as well as by performing a manual review of references.

[Application of nickel-titanium shape memory staples in treatment of multiple metatarsal fractures].

Objective: To investigate the effectiveness of nickel-titanium shape memory staples in treating multiple metatarsal fractures.

Methods: The clinical data of 27 patients with multiple metatarsal fractures who were treated between January 2022 and June 2023 and met the selection criteria were retrospectively analysed. The cohort consisted of 16 males and 11 females, aged 33-65 years (mean, 47.

Long non-coding RNA AK007111 mediates mast cells apoptosis via targeting of protein MOAP1.

Background: Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological processes in a variety of diseases including asthma. In this study, we reported the identification of lncRNA-AK007111 as an essential modulator of mast cell apoptosis and investigated its potential mechanism.

Methods: RNA-seq profiling and transcriptome sequencing technology were adopted to screen for differentially expressed genes.

Cancer Cell and Cancer-Associated Fibroblast Communication-Mediated Molecular Subtypes Portray Non-Inflamed Tumor Microenvironment and Guide the Precision Treatment of Bladder Cancer.

Cancer-associated fibroblasts (CAFs) drive tumor progression through restructuring of the tumor microenvironment. This investigation aim to elucidate the function of molecular subtypes (MS) derived from cancer cells communication with CAFs, depicting the hallmarks of the tumor microenvironment and precise bladder cancer (BLCA) treatment. The BLCA data from TCGA and several external sources are utilized to generate a novel ligand, receptor, and transcription factor (LRT) associated molecular subtype and their corresponding score (LRT score).

MBST-Driven 4D-CBCT reconstruction: Leveraging swin transformer and masking for robust performance.

Objective: This research developed an innovative Mask-based Swin Transformer network (MBST) to enhance the quality of 4D cone-beam computed tomography (4D-CBCT) reconstruction. The network is trained on 4D-CBCT reconstructed under limited scanning conditions, enabling its application to a broad range of 4D-CBCT reconstruction scenarios, including those with high scanning speeds.

Methods: 4D imaging data from 20 patients with thoracic tumors were used to train and evaluate the deep learning model.

Calculation of CT ideal screw path and safety angle before percutaneous sacroiliac screw placement.

Introduction: Percutaneous sacroiliac screw placement is the main surgical approach to treat unstable posterior pelvic ring injuries. Intraoperative fluoroscopic imaging is an important part of safe sacroiliac screw placement. However, how to determine the right perspective view is challenging.

Effect of weight loss following Roux-en-Y gastric bypass on cancer risk: A Mendelian randomization study.

Cancer incidence and development are strongly correlated with obesity, however there is insufficient data to support a causal relationship between intentional weight loss and the prevention or promotion of cancer. We investigated the causal relationship between weight loss following Roux-en-Y gastric bypass (RYGB) and the incidence of 18 cancers using Mendelian randomization (MR). A genome-wide association studies (GWAS) data related to weight loss following RYGB from the GWAS catalog database were used as exposure, and GWAS data related to 18 cancers from the Medical Research Council integrative epidemiology unit open GWAS project were used as outcomes.

Virtual biopsy for non-invasive identification of follicular lymphoma histologic transformation using radiomics-based imaging biomarker from PET/CT.

Background: This study aimed to construct a radiomics-based imaging biomarker for the non-invasive identification of transformed follicular lymphoma (t-FL) using PET/CT images.

Methods: A total of 784 follicular lymphoma (FL), diffuse large B-cell lymphoma, and t-FL patients from 5 independent medical centers were included. The unsupervised EMFusion method was applied to fuse PET and CT images.

LncRNA PTS-1 Protects Against Osteoarthritis Through the miR-8085/E2F2 Axis.

Background: Osteoarthritis (OA) is a leading cause of pain, disability, and reduced mobility worldwide, characterized by metabolic imbalances in chondrocytes, extracellular matrix (ECM), and subchondral bone. Emerging evidence highlights the critical role of long non-coding RNAs (lncRNAs) in OA pathogenesis. This study focuses on lncRNA PTS-1, a novel lncRNA, to explore its function and regulatory mechanisms in OA progression.

Safety and effectiveness of dual therapy for Helicobacter pylori infection and the effect on the glycated hemoglobin level in type 2 diabetes.

Patients with diabetes have a high risk of failure of H. pylori eradication therapy. The present study aims to evaluate the efficacy and safety of vonoprazan-amoxicillin (VA) dual therapy for the treatment of H.

Low-carbohydrate diet score and chronic obstructive pulmonary disease: a machine learning analysis of NHANES data.

Background: Recent research has identified the Low-Carbohydrate Diet (LCD) score as a novel biomarker, with studies showing that LCDs can reduce carbon dioxide retention, potentially improving lung function. While the link between the LCD score and chronic obstructive pulmonary disease (COPD) has been explored, its relevance in the US population remains uncertain. This study aims to explore the association between the LCD score and the likelihood of COPD prevalence in this population.

Association between solid cooking fuels exposure and metabolic syndrome: Evidence from China.

Epidemiological evidence connecting cooking fuel use to metabolic syndrome (MetS) is lacking. Solid cooking fuel usage and MetS prevalence were prospectively investigated in this study. We included participants in 2011 and 2015 from the China Health and Retirement Longitudinal Study (CHARLS) data.

Acquired Nail Hypertrophy Due to Nickel Contact Allergy with Dermoscopic findings: A Case Report and Literature Review.

Nickel stands as one of the prevalent contact allergens, but acquired nail hypertrophy presenting as ACD due to nickel exposure is infrequent. Here we report a case of acquired nail hypertrophy stemming from ACD due to nickel, displaying an uneven coloration, along with nail grooves, deck distortion damage, small surface pits and ecchymosis beneath the damaged deck. The patient limited nickel contact and recovered after 11 months of follow-up.

Psychological stress and influence factors in elderly patients with mild coronary heart disease: a longitudinal follow-up study in Shanghai, China.

Introduction: Effective health management is crucial for elderly patients with coronary heart disease (CHD). This study applied a Psycho-Cardiology model to CHD management, aiming to assess psychological stress among patients with mild CHD and identify potential influencing factors to provide substantiating evidence.

Methods: This longitudinal study was based on a 9-year follow-up program of a community population in Shanghai, China.

and : Potential Therapeutic Targets for Gastric Cancer.

Background: Detecting and treating stomach cancer requires a comprehensive understanding of how gastric cancer develops and progresses. In this context, efforts have been made to elucidate the regulation of glutamine-fructose-6-phosphate transaminase 1 () and Lysine demethylase 4C () in gastric cancer.

Methods: Bioinformatics was utilized to predict the levels and correlation of and in gastric cancer, followed by determining their expressions via quantitative real-time polymerase chain reaction (qRT-PCR).