5 results match your criteria: "The Affiliated AnQing Municipal Hospitals of Anhui Medical University[Affiliation]"
4,8-dicarboxyl-8,9-iridoid-1-glycoside Promotes Neural Stem Cell Differentiation Through MeCP2.
Dose Response
August 2022
Department of Orthopedic, The Affiliated AnQing Municipal Hospitals of Anhui Medical University, AnQing, China.
Background: Borojó (Borojoa patinoi Cuatrec) fruit has recently been shown to have a variety of health benefit, but the mechanisms have been little studied. The aim of this study was to investigate the effect of 4,8-dicarboxyl-8,9-iridoid-1-glycoside (388) on proliferation and differentiation of embryonic neural stem cells (NSCs).
Methods: NSCs were treated with 388 and stem cell differentiation was determined by western blotting and immunofluorescence staining.
Anesthetic management of a giant paraganglioma resection: a case report.
BMC Anesthesiol
July 2022
Department of Endocrinology, The Affiliated AnQing Municipal Hospitals of Anhui Medical University, AnQing, China.
Background: Patients with pheochromocytomas are often diagnosed with acute myocardial infarction (AMI) due to initial symptoms of palpitations and chest tightness. We describe a case of AMI syndrome where a giant paraganglioma was unexpectedly identified. The anesthetic management of the paraganglioma resection was challenging and complex.
View Article and Find Full Text PDFDetermination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose-response trial.
BMC Anesthesiol
July 2022
Department of Anesthesiology, The Affiliated AnQing Municipal Hospitals of Anhui Medical University, 352th, Renming Road, AnQing, 246003, AnHui Province, China.
Article Synopsis
- Laryngeal mask airways (LMAs) might irritate patients during insertion, especially older adults, leading to potential safety issues due to hemodynamic changes.
- A study involving 90 geriatric patients (age ≥ 65) was conducted to find the effective dose of sufentanil required to minimize reactions during LMA insertion, using various dose levels and monitoring vital signs pre- and post-procedure.
- Probit regression analysis indicated that the median effective dose (ED50) of sufentanil for inhibiting responses to LMA insertion in older patients was approximately 0.18 µg/kg, with significant differences in physiological responses between effective and ineffective insertions.
Osthole-Mediated Inhibition of Neurotoxicity Induced by Ropivacaine via Amplification of the Cyclic Adenosine Monophosphate Signaling Pathway.
Dose Response
March 2022
Department of Orthopedics, The First Affiliated Hospitals of Sun Yat-Sen University, GuangZhou, China.
Background: Ropivacaine is widely used for clinical anesthesia and postoperative analgesia. However, the neurotoxicity induced by ropivacaine in a concentration- and duration-dependent manner, and it is difficult to prevent neurotoxicity. Osthole inhibits phosphodiesterase-4 activity by binding to its catalytic site to prevent cAMP hydrolysis.
View Article and Find Full Text PDFDetermination of the Median Effective Dose of Dexmedetomidine for the Prevention of Emergence Agitation in Geriatric Patients Undergoing Major Open Surgery With General Anesthesia: A Prospective, Double-Blinded, Dose-Response Trial.
Dose Response
August 2021
Department of Anesthesiology, The Affiliated AnQing Municipal Hospitals of Anhui Medical University, AnQing, China.
Article Synopsis
- - The study explored the effective dose of dexmedetomidine for preventing emergence agitation (EA) in older patients undergoing major surgery under general anesthesia.
- - A sample of 50 geriatric patients was tested, and the median effective dose (ED50) determined was 0.30 μg·kg·h, with a predicted effective dose (ED95) of 0.42 μg·kg·h to manage EA.
- - Results indicated a significant increase in bradycardia (slow heart rate) among patients treated with dexmedetomidine when EA was not present, highlighting a major side effect of the medication.