2 results match your criteria: "The Affifiliated Lianyungang Hospital of Xuzhou Medical University[Affiliation]"
Pharmacological Inhibition or Silencing of TREM1 Restrains HCC Cell Metastasis by Inactivating TLR/PI3K/AKT Signaling.
Cell Biochem Biophys
September 2024
Department of Gastroenterology, The Affifiliated Lianyungang Hospital of Xuzhou Medical University, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, China.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a common cancer linked to inflammation, with TREM1 identified as a key player in its progression, though its specific role in HCC metastasis is still unclear.
- Research showed that TREM1 was significantly overexpressed in HCC tissue, correlating with worse survival rates, while inhibiting TREM1 reduced HCC cell growth, invasion, and the epithelial-mesenchymal transition (EMT).
- The study highlighted a connection between TREM1 and TLR2/4 pathways; blocking TREM1 affected signaling pathways involved in cancer cell behavior, and decreasing TREM1 also suppressed tumor growth and spread in animal models, suggesting it could be a therapeutic target
Application and Clinical Value of Machine Learning-Based Cervical Cancer Diagnosis and Prediction Model in Adjuvant Chemotherapy for Cervical Cancer: A Single-Center, Controlled, Non-Arbitrary Size Case-Control Study.
Contrast Media Mol Imaging
July 2022
Department of Obstetrics, The Affifiliated Lianyungang Hospital of Xuzhou Medical University, No. 182, Tongguan North Road, Lianyungang 222000, Jiangsu, China.
Objective: A case-control study was conducted to explore the application and clinical value of machine learning-based cervical cancer (CC) diagnosis and prediction model in adjuvant chemotherapy of CC.
Methods: From August 2019 to August 2021, 46 patients with stage IA CC (study group) and 55 patients with high-grade squamous intraepithelial lesions (HSIL) (control group) were retrospectively analyzed. All patients completed routine MRI examinations, the ADC values of diseased CC and normal cervix and cervical tissues in different stages were compared, and the changes of ADC values in CC tissues before and after chemotherapy were analyzed.