51 results match your criteria: "The ADA Forsyth Institute; Cambridge[Affiliation]"
NPJ Biofilms Microbiomes
January 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus & Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Emerging evidence indicates that oral microbes are closely related to gastric microbes and gastric lesions, including gastric atrophy, intestinal metaplasia and gastric cancer (GC). Helicobacter pylori is a key pathogen involved in GC. However, the increasing prevalence of H.
View Article and Find Full Text PDFACS Synth Biol
December 2024
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, United States.
J Dent Res
December 2024
The ADA Forsyth Institute Inc., Cambridge, MA, USA.
Tooth enamel maturation requires the removal of proteins from the mineralizing enamel matrix to allow for crystallite growth until full hardness is reached to meet the mechanical needs of mastication. While this process takes up to several years in humans before the tooth erupts, it is greatly accelerated in the faster-developing pigs. Pig teeth erupt with softer, protein-rich enamel that is similar to hypomineralized human enamel but continues to harden quickly after eruption.
View Article and Find Full Text PDFGut Microbes
December 2025
Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Cancerous tissue is a largely unexplored microbial niche that provides a unique environment for the colonization and growth of specific bacterial communities, and with it, the opportunity to identify novel bacterial species. Here, we report distinct features of a novel species, sp. nov.
View Article and Find Full Text PDFJ Appl Biomater Funct Mater
December 2024
Faculty of Dentistry, University of Hong Kong, Hong Kong, China.
Background: A stable copper tetraamine fluoride (CTF) with low cytotoxicity has been developed for dental use.
Objective: To investigate the antimicrobial effects of CTF against common microbes associated with dental caries and periodontal disease.
Method: The minimum inhibitory concentrations (MIC) and minimum bactericidal/fungicidal concentrations (MBC/MFC) were used to evaluate the antimicrobial effects of CTF against eight common bacteria and one fungus associated with dental caries and periodontal disease.
bioRxiv
November 2024
Department of Microbiology, ADA Forsyth Institute, Cambridge MA, 02142, USA.
All cultivated Patescibacteria, or CPR, exist as obligate episymbionts on other microbes. Despite being ubiquitous in mammals and environmentally, molecular mechanisms of host identification and binding amongst ultrasmall bacterial episymbionts are largely unknown. Type 4 pili (T4P) are well conserved in this group and predicted to facilitate symbiotic interactions.
View Article and Find Full Text PDFMicrobiol Resour Announc
November 2024
Department of Periodontics, University of Washington, Seattle, Washington, USA.
strain BB002, was isolated from the human oral cavity on its basibiont bacterial host sp. oral taxon 171 strain F0337, related to . As a member of the within the candidate phylum radiation group (CPR), its reduced genome facilitates the survival as an ultrasmall (<0.
View Article and Find Full Text PDFJ Infect Dis
November 2024
Wellman Center for Photomedicine, Massachusetts General Hospital (MGH), Boston, MA, USA.
We developed a translational prototype antimicrobial blue light (ABL) device for treating skin wounds with ABL. Partial-thickness surgical wounds were created in live swine, an animal whose skin is considered the most like human skin, then heavily contaminated and left untreated for 24 hours with methicillin-resistant Staphylococcus aureus (MRSA). ABL treatment stabilized and reduced MRSA infection by greater than four orders of magnitude (>99.
View Article and Find Full Text PDFJ Dent
December 2024
Faculty of Dentistry, University of Hong Kong, Hong Kong, China. Electronic address:
Objective: To investigate the antibacterial, remineralising, and discolouring effects of copper tetraamine fluoride (CTF) on artificial enamel caries.
Method: Human enamel blocks with artificial caries were treated with CTF, silver diamine fluoride (SDF, positive control) and water (negative control) before being challenged with Streptococcus mutans. The morphology, viability, and growth kinetics of biofilm were evaluated using scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and colony-forming unit (CFU) counting.
J Dent
December 2024
Faculty of Dentistry, University of Hong Kong, Hong Kong, China. Electronic address:
Objective: To investigate the antibacterial, mineralising, and discolouring properties of copper tetraamine fluoride (CTF) on artificial dentine caries.
Method: Demineralised human dentine blocks were treated with CTF, silver diamine fluoride (SDF, positive control) and water (negative control) before they were subjected to cariogenic challenge with Streptococcus mutans biofilm. The morphology, viability, and growth kinetics of the biofilm were assessed by scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and colony-forming unit (CFU) counting.
Braz Dent J
October 2024
School of Dental Medicine, Albert Einstein Israelite Hospital, São Paulo, SP, Brazil.
The necessity for regenerating peri-implant and periodontal tissues is increasingly apparent. Periodontal diseases can result in a significant loss of clinical attachment level, and tissue regeneration stands as the ultimate goal of periodontal therapy. With the rise of osseointegration, the prosthetic rehabilitation of missing teeth using dental implants has surged, leading to a frequent need for alveolar bone regeneration around implants.
View Article and Find Full Text PDFBraz Dent J
October 2024
Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
J Periodontal Res
September 2024
Laboratory of Neuroimmune Interface of Pain Research, Faculdade São Leopoldo Mandic, Instituto de Pesquisa São Leopoldo Mandic, Campinas, Brazil.
Aims: Periodontitis is a prevalent inflammatory disorder affecting the oral cavity, driven by dysbiotic oral biofilm and host immune response interactions. While the major clinical focus of periodontitis treatment is currently controlling oral biofilm, understanding the immune response is crucial to prevent disease progression. Soluble epoxide hydrolase (sEH) inhibition has shown promise in preventing alveolar bone resorption.
View Article and Find Full Text PDFJ Funct Biomater
September 2024
Faculty of Dentistry, University of Hong Kong, Hong Kong, China.
J Periodontol
September 2024
ADA Forsyth Institute, Cambridge, Massachusetts, USA.
Background: Behçet's disease (BD) pathogenesis involves severe outcomes such as blindness, central nervous system manifestations, and deep venous thrombosis that impacts systemic and local inflammatory changes. We tested the hypothesis that BD negatively affects gingival health and increases the severity of gingivitis.
Methods: The study included 37 BD patients with gingivitis without any sign of periodontitis.
Mol Immunol
October 2024
The ADA Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA. Electronic address:
Sjӧgren's syndrome (SS), also known as Sjögren's disease, is a chronic autoimmune condition predominantly affecting the salivary and lacrimal glands. The disease is driven by autoimmune responses involving the activation and actions of major innate- and adaptive immune cell subsets. However, the specific characteristics and roles of regulatory T cells (Tregs) in SS remain elusive.
View Article and Find Full Text PDFJ Clin Orthod
June 2024
Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders/Section of CMD, Campus Benjamin Franklin; Center for Dental and Craniofacial Sciences (CC3), Charité-Universitätsmedizin Berlin; Freie Universität Berlin, Humboldt-Universität zu Berlin; Berlin Institute of Health, Berlin, Germany.
Periodontol 2000
October 2024
ADA Forsyth Institute, Cambridge, Massachusetts, USA.
Chronic inflammation poses challenges to effective cancer treatment. Although anti-inflammatory therapies have shown short-term benefits, their long-term implications may be unfavorable because they fail to initiate the necessary inflammatory responses. Recent research underscores the promise of specialized pro-resolving mediators, which play a role in modulating the cancer microenvironment by promoting the resolution of initiated inflammatory processes and restoring tissue hemostasis.
View Article and Find Full Text PDFmSystems
September 2024
Department of Cell and Molecular Biology, University of Rhode Island, Kingston, Rhode Island, USA.
Microbiol Spectr
October 2024
Department of Oral Science and Translational Research, Health Professions Division, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Biochim Biophys Acta Mol Cell Res
October 2024
The ADA Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA. Electronic address:
Intermittent fasting exerts a profound beneficial influence on a spectrum of diseases through various mechanisms including regulation of immune responses, elimination of senescent- and pathogenic cells and improvement of stem cell-based tissue regeneration in a disease- and tissue-dependent manner. Our previous study demonstrated that alternate-day fasting (ADF) led to alleviation of xerostomia and sialadenitis in non-obese diabetic (NOD) mice, a well-defined model of Sjögren's syndrome (SS). This present study delved into the previously unexplored impacts of ADF in this disease setting and revealed that ADF increases the proportion of salivary gland stem cells (SGSCs), defined as the EpCAM cell population among the lineage marker negative submandibular gland (SMG) cells.
View Article and Find Full Text PDFJ Oral Microbiol
August 2024
Immunology and Infectious Diseases, The ADA Forsyth Institute, Cambridge, MA, USA.
Background: , a pathobiont in periodontal disease, contributes to alveolar bone destruction. We assessed the efficacy of a new targeted antimicrobial, FP-100, in eradicating from the oral microbial community and and evaluated its effectiveness in reducing bone loss in a mouse periodontitis model.
Methods: A multispecies bacterial community was cultured and treated with two concentrations of FP-100 over two days.
J Periodontal Res
August 2024
Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
bioRxiv
July 2024
Department of Microbiology, The ADA Forsyth Institute; Cambridge, MA, 02142.
The unique epibiotic-parasitic relationship between type strain TM7x, a member of the newly identified Candidate Phyla Radiation, now referred to as and its basibiont, strain XH001 (formerly , require more powerful genetic tools for deeper understanding of the genetic underpinnings that mediate their obligate relationship. Previous studies have mainly characterized the genomic landscape of XH001 during or post TM7x infection through comparative genomic or transcriptomic analyses followed by phenotypic analysis. Comprehensive genetic dissection of the pair is currently cumbersome due to the lack of robust genetic tools in TM7x.
View Article and Find Full Text PDFJ Funct Biomater
July 2024
Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Objectives: This study developed a sol-gel tricalcium silicate/graphene oxide (TCS-GO) composite and examined its physicochemical properties, antimicrobial activity, and osteo/odontogenic effect on dental pulp stem cells.
Methods: Tricalcium silicate was synthesized and combined with graphene oxide at three different concentrations, namely 0.02%, 0.