32 results match your criteria: "The 900th Hospital of the Joint Logistic Support Force[Affiliation]"

Construction of a risk prediction model for isolated pulmonary nodules 5-15 mm in diameter.

Transl Lung Cancer Res

November 2024

Department of Pulmonary and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, The 900th Hospital of the Joint Logistic Support Force, People's Liberation Army of China, Fuzhou, China.

Article Synopsis
  • - The study aimed to create a prediction model for assessing the risk of malignancy in solitary pulmonary nodules (SPNs) that are 5-15 mm in size, acknowledging limitations in current detection technologies.
  • - A total of 417 patients were analyzed for clinical and imaging features, with key factors like smoking history, nodule characteristics, and specific signs being identified as significant in determining malignancy risks.
  • - The developed model showed strong predictive performance, outperforming existing models, with an area under the curve (AUC) of 0.814 for the training cohort and 0.864 for the validation cohort, indicating its high clinical usefulness.
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Is pulmonary vascular remodeling an intermediate link between hyperglycemia and adverse outcomes in patients with idiopathic pulmonary arterial hypertension? Insights from a multi-center cohort study.

Cardiovasc Diabetol

October 2024

Center for Respiratory and Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing, 100037, China.

Article Synopsis
  • - The study investigates the effects of stress hyperglycemia ratio (SHR), admission blood glucose (ABG), and hemoglobin A1c (HbA1c) on the severity and long-term outcomes of patients with idiopathic pulmonary arterial hypertension (IPAH), as prior research has not explored these relationships.
  • - Out of 625 patients monitored for an average of 3.8 years, 35% faced severe health events or death, with findings showing that higher SHR and ABG are strong independent predictors of these outcomes.
  • - Analysis revealed that pulmonary vascular resistance played a role in the relationship between hyperglycemia and clinical worsening, indicating it could mediate a significant portion of these outcomes.
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Chordoma combined with Trousseau syndrome: a case report and literature review.

J Thorac Dis

September 2024

Department of Respiratory and Critical Care Medicine, Fuzong Teaching Hospital, Fujian University of Traditional Chinese Medicine (900 Hospital), Fuzhou, China.

Article Synopsis
  • - Trousseau syndrome (TS) is a serious condition characterized by spontaneous blood clots in patients with tumors, often leading to high fatality rates; it is usually associated with aggressive cancers like lung, pancreatic, and breast cancer but has not been reported in chordoma until now.
  • - A 56-year-old male with chordoma underwent various treatments for his cancer, but after experiencing chest tightness, he was diagnosed with TS following findings of pulmonary artery embolisms on a CT scan.
  • - The case highlights the need for increased awareness among clinicians regarding the risk of TS in different tumors, including chordoma, as well as the importance of identifying sensitive markers for better diagnosis and management strategies.
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Article Synopsis
  • Patients with non-small cell lung cancer (NSCLC) who have specific mutations (-Mut) are often in a more advanced stage of the disease and have a poorer prognosis; however, there is limited research on this group due to the rarity of the mutations.
  • The study utilized data from The Cancer Genome Atlas (TCGA) and a clinical center to analyze clinical, pathological, and molecular characteristics of NSCLC -Mut patients, examining 481 samples from TCGA and 20 patients from the center.
  • Results indicated that -Mut patients had a significantly worse prognosis compared to wild-type (WT) patients, but those with Napsin A expression experienced longer overall survival, suggesting that Napsin A could be a potential prognostic
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Article Synopsis
  • A gene called CDT1 is super active in certain cancers, especially in lung adenocarcinoma (LUAD), where it helps control how cells copy themselves.
  • Research showed that CDT1 and another gene, E2F2, worked together more when people had LUAD, and reducing CDT1 made cancer cells grow and spread less.
  • Studying this in mice, scientists found that lowering CDT1 levels also helped shrink tumors, suggesting that CDT1 could be a target for new cancer treatments.
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(), a common opportunistic pathogen, is highly prone to chronic infection and is almost impossible to eradicate, especially attributed to virulence factors and adaptive mutations. In the present study, pseudomonas effector candidate 1 (Pec 1), a novel virulence factor of , was investigated, which inhibited bacterial clearance by the host and aggravated lung injury. Further, it demonstrated that Pec 1 inhibited miR-155 via suppressing integrin β3 expression, thereby activating PI3K-AKT-mTOR and inhibiting autophagy in macrophages.

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Background And Objective: The cancer-immunity cycle (CIC) is defined as a series of progressive events that cause an anticancer immune response leading to the killing of the cancer cell. The concept of CIC has important guiding significance for the clinical and basic tumor immunotherapy research. As one of the methods of traditional Chinese medicine (TCM), Chinese herbal medicine (CHM) has shown unique advantages in multitarget and multipathway immune regulation.

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Clinical and imaging characteristics of growing skull fractures in children.

Sci Rep

March 2024

Department of Neurosurgery, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.

Growing skull fracture (GSF) is an uncommon form of head trauma among young children. In prior research, the majority of GSFs were typically classified based on pathophysiological mechanisms or the duration following injury. However, considering the varying severity of initial trauma and the disparities in the time elapsed between injury and hospital admission among patients, our objective was to devise a clinically useful classification system for GSFs among children, grounded in both clinical presentations and imaging findings, in order to guide clinical diagnosis and treatment decisions.

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Background: Pneumocystis jirovecii pneumonia (PJP) is a life-threatening opportunistic infection in immunocompromised children with systemic lupus erythematosus (SLE). Prophylaxis against PJP in high-risk children is crucial, but the risk factors for PJP in children with SLE are not adequately characterized. This study sought to identify the risk factors for PJP in long-term glucocorticoid-treated pediatric SLE patients.

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Rechallenge of immune checkpoint inhibitors in advanced non-small cell lung cancer.

Thorac Cancer

February 2024

Department of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.

Article Synopsis
  • * A consensus among 147 experts revealed that a significant majority (97.74%) support rechallenging; while nearly half (48.87%) favor using the original drug, others prefer a different one.
  • * Factors like previous performance status, PD-1 expression, and patient age are important in deciding on rechallenge, especially after experienced progression or metastasis.
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Clinical definition of secondary resistance to immunotherapy in non-small cell lung cancer.

Thorac Cancer

December 2023

Department of Thoracic Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, People's Republic of China.

Immune checkpoint inhibitors (PD-1/PD-L1 and CTLA-4 blockade) have revolutionized the treatment landscape in non-small cell lung cancer (NSCLC). Secondary resistance to immunotherapy (IO), which poses a substantial challenge in clinical settings, occurs in several initial responders. Currently, new treatment approaches have been extensively evaluated in investigational studies for these patients to tackle this difficult problem; however, the lack of consistency in clinical definition, uniform criteria for enrollment in clinical trials, and interpretation of results remain significant hurdles to progress.

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Comparison of different therapeutic approaches for pulmonary cryptococcosis in kidney transplant recipients: a 15-year retrospective analysis.

Front Med (Lausanne)

July 2023

Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, The 900th Hospital of the Joint Logistic Support Force, Fuzhou, China.

Introduction: Organ transplant recipients are at increased risk of developing pulmonary cryptococcosis (PC) due to weakened cell-mediated immunity caused by immunosuppressors. However, the nonspecific symptoms associated with PC can often lead to misdiagnosis and inappropriate treatment.

Methods: We conducted a retrospective analysis of data from 23 kidney transplant recipients with PC between April 2006 to January 2021.

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Background: The usefulness of metagenomic next-generation sequencing (mNGS) in identifying the prognosis of lung cancer with chromosomal instability (CIN) remains unclear. We aimed to analyze clinical characteristics and prognosis of patients in patients harboring CIN.

Methods: This retrospective cohort study included 668 patients diagnosed with suspected pulmonary infection or lung cancer whose samples underwent mNGS detection from January 2021 to January 2022.

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Gene Mutation and Its Association with Clinicopathological Features in Young Patients with Non-Small-Cell Lung Cancer.

Emerg Med Int

July 2022

Department of Pulmonary and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, The 900th Hospital of the Joint Logistic Support Force, PLA, Fuzhou, Fujian 350025, China.

Background: We investigated the correlation between genetic mutations and clinical-pathological features in young patients with NSCLC.

Methods: Clinicopathologic information of 102 young NSCLC patients was collected. Direct ctDNA sequencing of a portion of these patients was performed.

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For those patients with hepatocellular carcinoma (HCC), it is really a heavy burden. Herein, the immune genes of HCC were analyzed in groups to determine prognostic biomarkers related to immune genes in HCC. The mRNA data, clinical data in TCGA-LIHC dataset, and immune gene in the ImmPort database were collected for the combining usage with -means concordance clustering to cluster HCC patients according to the immune gene matrix.

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Background: The aim of this study was to investigate the clinical features, immunohistochemistry (IHC), compound mutation, and prognosis of patients with non-small cell lung cancer (NSCLC) harboring exon 19 deletion-insertion mutations.

Methods: This retrospective analysis included 4,666 NSCLC patients harboring epidermal growth factor receptor (EGFR) mutations in a multi-center study from January 2017 to December 2020, and 69 patients with EGFR exon 19 deletion-insertions were taken to account. Next-generation sequencing (NGS) was used to detect the subtype of EGFR exon 19 deletion-insertions.

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Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial.

Cancer Cell

March 2022

Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou 510060, China. Electronic address:

Article Synopsis
  • Platinum-based chemotherapy, specifically toripalimab combined with paclitaxel and cisplatin, was tested against a placebo in a phase 3 trial for patients with advanced esophageal squamous cell carcinoma (ESCC).
  • The results showed that those treated with toripalimab experienced significantly better progression-free survival (PFS) and overall survival (OS) compared to the placebo group.
  • Both treatment groups had similar rates of serious side effects, indicating that the toripalimab plus chemotherapy regimen is effective and has a manageable safety profile.
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Outcomes in Patients With Lung Adenocarcinoma With Transformation to Small Cell Lung Cancer After EGFR Tyrosine Kinase Inhibitors Resistance: A Systematic Review and Pooled Analysis.

Front Oncol

January 2022

Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, Department of Respiratory and Critical Care Medicine, The 900th Hospital of the Joint Logistic Support Force, PLA, Fuzhou, China.

Background: Lung adenocarcinoma can transform into small-cell lung cancer (SCLC) when resistance to tyrosine kinase inhibitors (TKIs) develops. Approximately 3% to 10% of epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) could transform to SCLC. This phenomenon has been described in several case reports and small patient series.

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Though patients with hepatocellular carcinoma (HCC) benefit from the treatment of immune checkpoint inhibitor (ICB), it is still of vital significance to develop more effective drugs and predict patients' response to ICB therapy. Herein, we utilized single sample gene set enrichment analysis (ssGSEA) to score the downloaded tumor samples from TCGA-LIHC based on 29 immune gene sets, thus reflecting the immunologic competence of samples. Then samples were classified into high, moderate, and low immunity groups.

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[Diagnosis and treatment of pneumonia: experiences of 8 cases].

Zhonghua Jie He He Hu Xi Za Zhi

June 2021

Department of Respiratory and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Dongfang Hospital of Xiamen University, the 900th Hospital of the Joint Logistic Support Force, PLA, Fuzhou 350025, China.

In order to improve the understanding and clinical treatment of pneumonia, we analyzed the clinical manifestations, laboratory test results and imaging features of 8 patients. We collected the clinical data of 8 patients with pneumonia diagnosed by metagenomic next-generation-sequencing (mNGS) from November 2018 to February 2020, including clinical features, chest CT scan, pathological features and antibiotic use. A total of one male and 7 females, aged from 45 to 85 years(median 62 years), were included in this study.

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