[DNA methylation of prostate cancer and clinical application].

It is well-known that the interaction of both genetic and epigenetic mechanisms results in the formation of malignant tumor. Epigenetic mechanism includes DNA methylation, histone modifications, and miRNA regulation. DNA aberrant methylation (hypermethylation and hypomethylation), which leads to genomic instability and inappropriate gene expression, is the best-characterized alteration in prostate cancer.

[Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi].

Objective: To assess the association between SIRT1 gene polymorphisms and the longevity phenomena in Yongfu region of Guangxi. In this case-control study, 500 individuals from Yongfu region of Guangxi were recruited. The subjects were divided into a longevity group (n=223, average age=93.

[Genetic mechanisms of longevity responses to dietary restriction].

Dietary restriction effectively extends lifespan in mammals and decreases the incidence and progression of many age-dependent diseases. To understand the genetic mechanisms that longevity responses to dietary restriction would have far-reaching impacts on future medical treatments to deal with the ageing problems. Until recently, we knew nothing about these mechanisms in metazoans.