Zanubrutinib Versus Bendamustine and Rituximab in Patients With Treatment-Naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Median 5-Year Follow-Up of SEQUOIA.

JCO SEQUOIA (ClinicalTrials.gov identifier: NCT03336333) is a phase III, randomized, open-label trial that compared the oral Bruton tyrosine kinase inhibitor zanubrutinib to bendamustine plus rituximab (BR) in treatment-naïve patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The initial prespecified analysis (median follow-up, 26.

An identification guide to the genera of aquatic larval Chironomidae (Diptera) of south-east Asia.

We provide illustrated dichotomous keys for the identification of final (4th) instar larvae of south-east Asian genera of Chironomidae (Diptera), predominantly from aquatic (freshwater and maritime) habitats. The region considered comprises oriental China, Burma, Thailand, Malaysia (west and east), Brunei, Singapore and Indonesia. Eight subfamilies are represented and phylogenetically validated tribes are keyed.

First record of Bagauda aelleni (Hemiptera: Reduviidae) from India and notes on its natural history in Sri Lanka.

Bagauda aelleni Villiers, 1970 (Hemiptera: Heteroptera: Reduviidae: Emesinae: Leistarchini), described from Sri Lanka, is reported from India for the first time. Based on specimens collected at Sirumalai, Tamil Nadu, the species is redescribed and various aspects of its morphology and life history are highlighted and illustrated.

High rates of MHC mismatches in HLA matched unrelated donor/recipient pairs and potential impact on hematopoietic cell transplant outcome.

Introduction: Donors for patients requiring hematopoietic cell transplant (HCT) are selected based on matching genetic sequences encoding the antigen recognition domain of specific HLA loci. However, differences in transplant outcomes in fully matched unrelated HCT compared with sibling HCT suggest that other genetic regions within the major histocompatibility complex (MHC) may contribute to HCT outcomes.

Methods: We sequenced the non-classical MHC loci (NCML) HLA-E, -F, -G, -H, MICA and MICB on a well-characterized retrospective cohort of 157 unrelated donor/recipient HCT pairs to determine the extent of MHC mismatching in matched pairs.

Effectiveness of unilateral lower-limb exoskeleton robot on balance and gait recovery and neuroplasticity in patients with subacute stroke: a randomized controlled trial.

Background: Impaired balance and gait in stroke survivors are associated with decreased functional independence. This study aimed to evaluate the effectiveness of unilateral lower-limb exoskeleton robot-assisted overground gait training compared with conventional treatment and to explore the relationship between neuroplastic changes and motor function recovery in subacute stroke patients.

Methods: In this randomized, single-blind clinical trial, 40 patients with subacute stroke were recruited and randomly assigned to either a robot-assisted training (RT) group or a conventional training (CT) group.

Dimensional versus categorical approach: A comparative study of mathematical cognition.

Background: Researchers have employed two distinct methods to understand the cognitive underpinnings of mathematical ability: categorical and dimensional. These two methods have different underlying assumptions. However, to the best of our knowledge, research to date has not empirically tested which method can better predict variance in mathematical ability.

Gender diversity and daily steps: Findings from the Adolescent Brain Cognitive Development Study.

Purpose: To examine the association between multiple dimensions of gender diversity and physical activity (daily steps) in a diverse national sample of early adolescents in the United States.

Methods: This study analyzed Year 2 data from the Adolescent Brain Cognitive Development (ABCD) Study (N = 6038, M=12.0 years).

Clinical evaluation of AYUSH-SL in patients receiving mass drug administration for the treatment of chronic inflammatory lymphedema, a double blind, placebo controlled, multicentric study.

Background Objectives: A 2.5-year placebo controlled double blind trial was conducted to investigate the safety and efficacy of AYUSH- SL, a poly- herbal Ayurvedic formulation on filarial lymphedema in different endemic areas of India. Lymphatic filariasis (LF) is caused by parasitic nematodes from Wuchereria bancrofti, Brugia malayi, or B.

Feasibility of interventions to increase HPV vaccination acceptability and coverage in school-based programs: Findings from a pilot study in Quebec, Canada.

Introduction: Human papillomavirus (HPV) vaccines have been offered in Quebec schools to 4th-grade (9-10 years old) girls since 2008 and boys since 2016. HPV vaccine coverage does not reach the 90 % target in many regions. This project evaluated the feasibility and the acceptability of interventions to improve HPV vaccine acceptability and coverage in school-based programs.

Cholera outbreak in a rural south - south Nigerian community: A case-control study.

Background: Cholera remains a disease of public health importance in Nigeria associated with high morbidity and mortality. On the 4 of June 2024, the Nigeria center for disease and control prevention (NCDC) through the Disease Surveillance and Notification Officer (DSNO) reported an increase in the number of reported cases of vomiting and diarrhea in Toru-Orua village, Sagbama Local Government Area Council, Bayelsa State, Nigeria. A team of researchers were deployed to investigate the outbreak with the objectives of verifying the diagnosis, identifying risk factors and instituting appropriate control measures to control the outbreak.

Effect of submucosal dexamethasone on postoperative pain, swelling and trismus after periodontal surgery: a randomized clinical study.

Objective: The aim of this study is to evaluate the effectiveness of submucosal 8 mg (2 mL) dexamethasone (DEX) on postoperative pain, swelling, chewing efficiency, trismus, healing, and discomfort after periodontal flap surgery (PFS).

Methods: In this randomized controlled split-mouth study, 25 patients underwent PFS in the mandible, whereby postoperative, submucosal DEX was injected to the surgical field to the test group and submucosal normal saline was applied to the control group. Pain was evaluated using the Visual Analogue Scale (VAS) and the 101-point numeric rate scale in the first 8 h after PFS and on the 2nd, 3rd, 4th, and 7th days, whereas swelling, chewing efficiency, trismus, healing, discomfort and analgesic consumption were evaluated preoperatively on the 1st, 2nd and 7th days.

Transcriptomic analysis of regulatory mechanisms in the telogen-anagen transition of ovine hair follicles.

Background: Dorper sheep are celebrated for their fast maturation and superior meat quality, with some shedding their wool each spring. Wool shedding occurs naturally due to the hair follicle (HF) cycle, but its regulatory mechanisms remain unclear and need further investigation.

Results: In this study, shedding and non-shedding sheep were selected from the same Dorper flock.

Development and Evaluation of the Global Appraisal of Individual Needs Quick Version 4 (GAIN-Q4) for ASAM Dimension Ratings and Placement Recommendations for Adolescents and Adults.

Objectives: This article describes the development and evaluation of the Global Appraisal of Individual Needs Quick Version 4 (GAIN-Q4) for the American Society of Addiction Medicine (ASAM) 4th edition patient placement dimension ratings and level of care placement recommendations. The research questions are as follows: (1) Can the GAIN-Q4 replicate recommendations from the prior longer instrument within adolescents and adults? (2) What are the substantive differences in the results by age?

Methods: The 35- to 45-minute GAIN-Q4 was developed through modification of the GAIN-Q3 and evaluated in terms of its ability to predict ASAM dimensional ratings and level of care placement recommendations from the 60- to 120-minute GAIN-I instrument. Data were obtained from participants who are adolescents aged 12 to 17 years (n = 101,897) and adults 18 years and older (n = 204,711) interviewed between 2002 and 2018 across 530 US sites.

Impact of Extreme Heat on Cardiovascular Health in Kuwait: Present and Future Projections.

Background: The Middle East, especially Kuwait, is experiencing rapidly rising temperatures due to climate change. Cardiovascular diseases (CVD) are the leading cause of mortality in the country, and extreme heat is expected to exacerbate hospitalizations for cardiovascular diseases. There is limited data quantifying the historical and future impacts of heat on hospitalizations for cardiovascular diseases in Kuwait.

Comparison of the treatment efficacy of suprascapular nerve block and intra-articular shoulder injection techniques in patients diagnosed with adhesive capsulitis.

Background: Adhesive capsulitis (AC) is a common cause of shoulder disability. Interventional procedures are used along with many other treatment methods. There are insufficient studies directly comparing the superiority of suprascapular nerve block (SSNB) and intra-articular shoulder injection (IAI) techniques, which are frequently used interventional methods in treatment.

Effect of telerehabilitation assessment for adults with musculoskeletal conditions on access to care beyond the COVID-19 pandemic: A retrospective case-control analysis.

Background: Musculoskeletal (MSK) conditions are the leading cause of disability worldwide. In MSK care, access to physical therapy is a major issue. The effectiveness of telerehabilitation phone assessment in improving access to care for MSK conditions has not yet been established in Saudi Arabia.

The potential of exosomes from adipose-derived stromal-vascular fraction in Increasing Migration Activity of Human Dental Pulp Stromal Cells (in vitro ).

Background: Migration of dental pulp stromal cells (DPSCs) significantly responds to wound healing after pulp injury. Deriving from low compliance characteristics, pulp tissue regeneration is challenging and depends on the microenvironmental signals. Exosomes can maintain and carry bioactive proteins that are crucial in cell communication.

DETECTION OF NEW HIV CASES UNDER EPIDEMIC CONTROL - WHEN IS IT THE RIGHT TIME TO REVIEW HIV TESTING ALGORITHMS FOR COUNTRIES NEARING THE 95-95-95 MILESTONES? CASE STUDY -BOTSWANA.

Background: Accurate diagnosis of human immunodeficiency virus (HIV) infection is dependent on using established national HIV testing algorithm. The purpose of this study was to review published articles to identify, and apply lessons learned to determine factors affecting transition of HIV testing algorithm for countries that have attained HIV epidemic control.

Materials And Methods: We systematically searched peer-reviewed articles from online scientific databases; PubMed and Google Scholar from January 2019 to March 2024, using defined search phrases to extract articles.

The Good, the Bad, and the Ugly: The Journey of an Architect-Researcher in Palliative Environments.

As an architect, I felt a strong moral urge to engage in research aimed at creating more human-centred healthcare environments, particularly in the context of palliative care. Being relatively new to this field 4 years ago, my primary goal then was to develop a deep understanding of these unique contexts, with a special focus on the people involved. To achieve this, I embarked on an immersive ethnographic study over the last few years, involving participant observations in three distinct palliative environments (i.

Outdoor health intervention for refugees, migrants, and asylum-seekers: A mixed-methods pilot study.

Despite the multifaceted and diverse challenges that refugees, migrants, and asylum-seekers experience when entering a new country, they remain notably underrepresented in the evaluation and understanding of the health and wellbeing impacts of outdoor health interventions. We addressed this knowledge gap by a mixed-methods evaluation (questionnaires, focus groups and photo elicitation activity) facilitated by a community researcher. Qualitative data (focus groups and photo elicitation activity) revealed that the participants saw the social component of outdoor activities as a critical factor in improving their wellbeing, an insight not captured by established quantitative wellbeing scales.