4 results match your criteria: "The 302 Military Hospital of China[Affiliation]"

Background And Objectives: Malnutrition is a major contributor to morbidity and mortality from pediatric liver disease. We investigated the prevalence of both malnutrition and high nutritional risk in hospitalized children with liver disease as well as the rate of in-hospital nutritional support.

Methods And Study Design: A total of 2,874 hospitalized children and adolescents with liver disease aged 1 to 17 years (inclusive) were enrolled.

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BACKGROUND We aimed to evaluate the combination therapy of Chinese herbs plus interferon and ribavirin in treatment of patients with chronic hepatitis C (CHC). MATERIAL AND METHODS Related databases were searched to identify randomized controlled trials (RCTs) that evaluated biochemical response, virological response, histological response, and/or adverse reactions to combination therapy of interferon and ribavirin with and without Chinese herbs. The RR (relative risk) with a 95% confidence interval (CI) was calculated.

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A new series of HAPs as anti-HBV agents targeting at capsid assembly.

Bioorg Med Chem Lett

September 2014

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Department of Medicinal Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China.

A series of novel Heteroaryldihydropyrimidines (HAPs) derivatives were designed and synthesized as potent inhibitors of HBV capsid assembly. These compounds were prepared from efforts to optimize an earlier series of HAPs, and compounds Mo1, Mo7, Mo8, Mo10, Mo12, and Mo13 demonstrated potent inhibition of HBV DNA replication at submicromolar range.

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Article Synopsis
  • The study investigates how rat drug serum affects the growth of liver cells (HSC-T6) when evaluating the drug peoniflorin found in Fufang Biejia Ruangan tablets.
  • By giving rats the tablets in different daily doses and measuring blood concentrations of peoniflorin over time, researchers aimed to find the most effective dosing frequency.
  • The findings suggest that taking the tablets twice a day provides the best therapeutic effects for combating liver fibrosis in chronic hepatitis, based on the relationship between drug concentration and its effects on liver cells.
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