New Insights into the Role of Inflammatory Pathways and Immune Cell Infiltration in Sleep Deprivation-Induced Atrial Fibrillation: An Integrated Bioinformatics and Experimental Study.

Background: The common occurrence of atrial fibrillation (AF) as a cardiac arrhythmia, along with its link to sleep deprivation (SD), is gaining more acknowledgment. Even with progress in comprehending the development of AF, the molecular connections between SD and AF are still not well-defined. The objective of this research was to pinpoint the shared molecular routes responsible for SD-induced AF and investigate possible treatment targets.

Levosimendan for sepsis-induced myocardial dysfunction: friend or foe?

Sepsis-induced myocardial dysfunction (SIMD) involves reversible myocardial dysfunction. The use of inotropes can restore adequate cardiac output and tissue perfusion, but conventional inotropes, such as dobutamine and adrenaline, have limited efficacy in such situations. Levosimendan is a novel inotrope that acts in a catecholamine-independent manner.

Immunopathological characteristics and therapeutic effects of UC-MSCs in a pigeon breeder's lung mouse model.

Hypersensitivity pneumonitis (HP), including pigeon breeder's lung (PBL), often progresses from acute inflammation to fibrosis, impairing lung function and limiting targeted therapeutic strategies. Mechanistic studies on PBL progression are limited by the lack of preclinical animal models and a predominant focus on patient data. This study explores the immunopathological characteristics of all stages of PBL in mice and evaluates the therapeutic potential of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) during the non-fibrotic stage.

Processed Products of Aconitum soongaricum Stapf. Inhibit the Growth of Ovarian Cancer Cells In vivo via Regulating the PI3K/AKT Signal Pathway.

Introduction/objective: The alkaloids of songorine, aconitine, and benzoylaconitine, as the processed products of Aconitum soongaricum Stapf., can significantly inhibit the migration and invasion of ovarian cancer cells in vitro. Herein, we studied the in vivo role and mechanism of these natural products in processed A.

Protective effect of low-dose lactulose in dextran sulfate sodium induced ulcerative colitis model of rats.

Although low-dose lactulose has shown a good theoretical foundation for the treatment of ulcerative colitis (UC) in previous studies, the exact effects and mechanism remain unclear. The rats were randomly distributed into 5 groups, i.e.

Prevalence of malnutrition among adult inpatients in China: a nationwide cross-sectional study.

Malnutrition substantially contributes to adverse clinical outcomes. However, no national survey has been conducted to characterize its epidemiology in hospital settings in China. We conducted the China Nutrition Fundamental Data 2020 project among a multistage stratified cluster sample of adult inpatients from 291 study sites across 30 provinces, autonomous regions and municipalities (except for Hong Kong, Macao, Taiwan Province, and the Xizang Autonomous Region, please see MATERIALS AND METHODS for details of the causes) of China to generate reliable data on the prevalence of malnutrition and explore the associated risk factors.

The association between serum albumin levels and metabolic syndrome based on the NHANES and two sample Mendelian randomization study.

Previous studies have shown that serum albumin levels are associated with a greater risk of metabolic syndrome (MetS). However, it is unclear whether this association is causal or only influenced by confounding factors, so further investigation is needed to determine the causal relationships. Researchers selected participants with serum albumin, metabolic syndrome, and related covariates from the National Health and Nutrition Examination Survey (NHANES) database for a total of 14,036 individuals, including 5483 individuals with MetS and 8553 individuals without MetS.

How Often Does Bacteremia Occur in Patients With Chronic Periprosthetic Joint Infection? A Prospective, Observational Study.

Background: Bacteremia is sometimes observed in patients with prosthetic joint infection (PJI), and it is associated with a lower likelihood of infection control. However, the prevalence and association of bacteremia in chronic PJI remain unknown.

Questions/purposes: (1) What percentage of patients are diagnosed with bacteremia at the time of hospital admission and before surgery for chronic PJI? (2) What clinical factors are associated with positive blood cultures? (3) To what degree are positive blood cultures associated with infection-free implant survival in patients with chronic PJI?

Methods: This prospective study was conducted at a single academic institution from June 2021 to August 2022.

Syringin inhibits the crosstalk between macrophages and fibroblast-like synoviocytes to treat rheumatoid arthritis via PDE4.

Background: Syringin (SRG) is well-known for its anti-inflammatory effects. However, its pharmacological mechanisms against rheumatoid arthritis (RA) are not fully understood.

Materials And Methods: We assessed the anti-RA effects of SRG using a collagen-induced arthritis (CIA) rat model.

Melatonin lessens the susceptibility to atrial fibrillation in sleep deprivation by ameliorating Ca mishandling in response to mitochondrial oxidative stress.

Background: The antiarrhythmic effect of melatonin(MLT) has been demonstrated in several studies; however, this hypothesis has recently been contested. Our research seeks to determine if exogenous MLT supplementation can reduce atrial fibrillation (AF) susceptibility due to sleep deprivation (SD) by addressing Ca mishandling and atrial mitochondrial oxidative stress.

Methods: Adult rats received daily MLT or vehicle injections and were exposed to a modified water tank.

Research progress of breast cancer surgery during 2010-2024: a bibliometric analysis.

Purpose: This study seeks to systematically analyze the research literature pertaining to breast cancer surgery from 2010 to 2024, as indexed in the PubMed database, employing bibliometric methodologies.

Methods: Employing the "bibliometrix" package in the R programming language, alongside VOSviewer and CiteSpace software, this research conducted a comprehensive visual analysis of 1,195 publications. The analysis encompassed publication trends, collaborative networks, journal evaluation, author and institutional assessments, country-specific analyses, keyword exploration, and the identification of research hotspots.

Prognostic nutritional index as a predictor of cardiovascular and all-cause mortality in American adults with hypertension: results from the NHANES database.

Background: Few studies have examined the relationship between nutritional status, as assessed by the Prognostic Nutrition Index (PNI), and incident cardiovascular mortality and all-cause mortality, particularly in hypertensive patients. This study aimed to examine the association between PNI and cardiovascular mortality and all-cause mortality in Americans with hypertension.

Methods: Data from this retrospective cohort study were obtained from the National Health and Nutrition Examination (NHANES) 1999-2016.

TransferBAN-Syn: a transfer learning-based algorithm for predicting synergistic drug combinations against echinococcosis.

Echinococcosis is a zoonotic parasitic disease caused by the larvae of echinococcus tapeworms infesting the human body. Drug combination therapy is highly valued for the treatment of echinococcosis because of its potential to overcome resistance and enhance the response to existing drugs. Traditional methods of identifying drug combinations via biological experimentation is costly and time-consuming.

Burden of type 2 diabetes due to high body mass index in different SDI regions and projections of future trends: insights from the Global Burden of Disease 2021 study.

Aim: The aim of our study was to assess the impact of high body mass index (BMI) on type 2 diabetes mellitus (T2DM) in different Socio-Demographic Development Index (SDI) regions using data from the Global Burden of Disease (GBD) 2021 study.

Methods: Using data from the GBD study, the burden of disease for T2DM was measured by analyzing the age-standardized disability-adjusted life year rate (ASDR) and age-standardized mortality rate (ASMR) for type 2 diabetes due to high BMI and the associated estimated annual percentage change (EAPC). Decomposition analyses, frontier analyses, and predictive models were used to analyze changes and influencing factors for each metric.

Cardiac hydatid cyst: case series and review of the literature.

Background: Echinococcosis is a zoonotic parasitic disease prevalent in pastoral areas, mainly involving the liver and lungs, and rarely affecting the brain and heart. This article describes the diagnosis and treatment of 14 patients with cardiac encapsulated cysts, with the aim of providing insights into the clinical presentation, diagnostic challenges, therapeutic strategies, and outcomes associated with cardiac encapsulated cysts.

Methods: This retrospective case series included 13 patients with cardiac and/or cerebral encapsulated cysts.

An Inter- and Intra-Rater Agreement Assessment of Two Novel Classification Systems for Coronal Imbalance in Adult Scoliosis and Spine Deformity.

Objective: Coronal malalignment is a common feature of adult spinal deformity, and accurate classification is essential for diagnosis and treatment planning. However, variations in interpretation among clinicians can impact classification consistency. By assessing the reliability and applicability of these systems across different medical experts, this study seeks to establish a standardized approach to enhance clinical outcomes.

Retrospective analysis of disease characteristics and treatment patterns among patients with esophageal cancer across 14 surgically represented centers.

Objective: Esophageal cancer (EC) ranks eighth among cancers in cancer-related deaths globally, and ~44% of new cases occur in China. We sought to describe the clinical characteristics and treatment landscape of EC in China before the approval of immunotherapy in 2020.

Methods: CHANNEL was a large, retrospective study using patient-level data from 14 hospitals/cancer centers across China, including adults initiating therapy for newly diagnosed EC (January to December 2018).

Risk factors and prediction model for sub-threshold depression in young and middle-aged breast cancer patients.

Objective: To explore the current status of subthreshold depression in young and middle-aged breast cancer patients and its influencing factors, in order to guide early identification and intervention in clinical settings.

Methods: The study included 385 young and middle-aged cancer patients treated at the First Affiliated Hospital of Xinjiang Medical University from June 2023 to June 2024. Standardized scales were used to evaluate sub-threshold depression, psychological resilience, and self-perceived burden.

Bland-Altman plot to assess the consistency of arterial and venous blood lactate in the emergency room: a retrospective cohort study.

To measure the correlation and agreement between arterial and peripheral venous blood lactate in the emergency room and to assess the predictive value of lactate for the occurrence of cardiac arrest. This was a retrospective cohort study involving 784 patients from January 1, 2020, to July 31, 2021, in the Emergency Room of the First Affiliated Hospital of Xinjiang Medical University. General information, vital signs, clinical symptoms, and laboratory findings of the patient were collected.

Real-world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study.

Azvudine and nirmatrelvir-ritonavir (Paxlovid) were widely used to treat patients with COVID-19 in China during the Omicron wave. However, the efficacy and safety of azvudine versus Paxlovid are poorly established. This study included 40,876 hospitalized patients with COVID-19 from eleven hospitals in Henan and Xinjiang Provinces, China.

Targeted Theranostic Nanoprobes Assisted NIR-II Fluorescence Imaging-Guided Surgery Therapy for Alveolar Echinococcosis.

Alveolar echinococcosis (AE) is a serious parasitic infectious disease that is highly invasive and destructive to the liver and has a high mortality rate. However, currently, there is no effective targeted imaging and treatment method for the precise detection and therapy of AE. We proposed a new two-step targeting strategy (TSTS) for AE based on poly(lactic--glycolic acid) (PLGA).

Investigating the role of age, admission systolic blood pressure, and neutrophil-to-lymphocyte ratio in predicting left ventricular hypertrophy among patients with primary hypertension.

Objective: In patients with primary hypertension (PH), left ventricular hypertrophy (LVH) is a critical predictor of cardiovascular events. We aimed to identify clinical and laboratory predictors of LVH in patients with PH.

Methods: This retrospective cohort study included 2321 patients with PH at the Fifth Affiliated Hospital of Xinjiang Medical University from December 2022 to January 2024.

The impact of community-based, non-pharmaceutical interventions on anxiety and depression in fibromyalgia: A systematic review and network meta-analysis.

Background: Fibromyalgia syndrome (FMS) is often accompanied by anxiety and depression, seriously affecting the prognosis of patients. Active non-pharmacological therapies are the mainstay of treatment, but the optimal choice is still contentious.

Methods: We did a network meta-analysis(NMA) of RCTs and compared 7 community-based non-pharmacological interventions based on 29 studies.

[High mobility group protein B1(HMGB1) promotes myeloid dendritic cell maturation and increases Th17 cell/Treg cell ratio in patients with immune primary thrombocytopenia].

Objective This study investigated the regulatory effect of high mobility group protein B1 (HMGB1) in the peripheral blood of patients with primary immune thrombocytopenia (ITP) on myeloid dendritic cells (mDC) and Th17/regulatory T cells (Treg) balance. Methods The study enrolled 30 newly diagnosed ITP patients and 30 healthy controls.Flow cytometry was used to measure the proportion of mDC, Th17, and Treg cells in the peripheral blood of ITP patients and healthy controls.