Development of Novel Magnetic Nanoparticles for Hyperthermia Cancer Therapy.

Advances in magnetic nanoparticle hyperthermia are opening new doors in cancer therapy. As a standalone or adjuvant therapy this new modality has the opportunity significantly advance thermal medicine. Major advantages of using magnetic magnetite (FeO) nanoparticles are their highly localized power deposition and the fact that the alternating magnetic fields (AMF) used to excite them can penetrate deeply into the body without harmful effect.

Microwave tomography in the context of complex breast cancer imaging.

The notion of applying microwave imaging to breast cancer imaging has been studied at various levels by numerous scientists. The earliest appeal of this concept related to the presumably high property contrast between benign and malignant tissue that was unique to the breast. Subsequent published studies have shown that this assumption was overly simplistic and that the tissue property heterogeneity is considerable within the breast.

Microwave tomographic imaging for osteoporosis screening: a pilot clinical study.

We are developing a microwave tomographic system for assessment of overall bone health. We hypothesize that as the mineralization of bone decreases due to the normal aging process and for more extreme situations such as osteoporosis, the dielectric property signature will also vary accordingly. To determine the merits of this approach, we have begun by performing initial exams of the heel to assess the level of image quality achievable.

Reactor scale up for biological conversion of cellulosic biomass to ethanol.

The absence of a systematic scale-up approach for biological conversion of cellulosic biomass to commodity products is a significant bottleneck to realizing the potential benefits offered by such conversion. Motivated by this, we undertook to develop a scale-up approach for conversion of waste paper sludge to ethanol. Physical properties of the system were measured and correlations were developed for their dependence upon cellulose conversion.

Dual-frequency ultrasound detection of stationary microbubbles in tissue.

Indirect evidence suggests that microbubbles that exist normally in tissue may play a key role in decompression sickness (DCS). Their sizes and locations are unknown. Dual-frequency ultrasound (DFU) exploits bubble resonance to detect bubbles over a wide size range and could potentially detect stationary tissue microbubbles.

Imaging forearm blood flow with pulse-ox gated electrical impedance tomography.

Assessing peripheral vasculature health has the potential to impact clinical decision making in terms of treating patients with cardiovascular disease. The electrical conductivity of certain tissue regions within the forearm change as blood vessels undergo pulsatile dilation in synchrony with the beating of the heart. We use dynamic electrical impedance tomography (EIT) gated to the peak of a pulse oxymetry plethysmography waveform to image this temporally varying spatial conductivity.

Kinetic modeling of cellulosic biomass to ethanol via simultaneous saccharification and fermentation: Part I. Accommodation of intermittent feeding and analysis of staged reactors.

The model of South et al. [South et al. (1995) Enzyme Microb Technol 17(9): 797-803] for simultaneous saccharification of fermentation of cellulosic biomass is extended and modified to accommodate intermittent feeding of substrate and enzyme, cascade reactor configurations, and to be more computationally efficient.

Kinetic modeling of cellulosic biomass to ethanol via simultaneous saccharification and fermentation: Part II. Experimental validation using waste paper sludge and anticipation of CFD analysis.

A kinetic model of cellulosic biomass conversion to ethanol via simultaneous saccharification and fermentation (SSF) developed previously was validated experimentally using paper sludge as the substrate. Adsorption parameters were evaluated based on the data obtained at various values for fractional cellulose conversion. The adsorption model was then combined with batch SSF data to evaluate the cellulose hydrolysis parameters.

Dislocation identification and in situ straining in the spinodal Fe30Ni20Mn25Al25 alloy.

Dislocations in the spinodal alloy Fe(30)Ni(20)Mn(25)Al(25), which is composed of alternating BCC and B2 (ordered BCC) phases, have been investigated using weak-beam transmission electron microscopy (TEM). The alloy was compressed at room temperature in an as-hot-extruded state to strains of approximately 3% for post-mortem dislocation analysis. Dislocations with a/2<111> Burgers vectors were found to glide in pairs on both {110} and {112} slip planes.