Perturbation of hyperthermia resistance in gastric cancer by hyperstimulation of autophagy using artemisinin-protected iron-oxide nanoparticles.

In a bid to overcome hyperthermia resistance, a major obstacle in cancer treatment, this study explores manipulating autophagy, a cellular recycling mechanism, within the context of gastric cancer. We designed artemisinin-protected magnetic iron-oxide nanoparticles (ART-MNPs) to hyperactivate autophagy, potentially sensitizing cancer cells to hyperthermia. The synthesized ART-MNPs exhibited magnetic properties and the capability of raising the temperature by 7 °C at 580.

Synthesis, microstructural and optical characterizations of sol-gel grown gadolinium doped cerium oxide ceramics.

In this study, through the utilization of the sol-gel combustion tactic, gadolinium (Gd)-doped cerium oxide (CeO), CeGdO ( = 0.00, 0.10, 0.

Photophysical Study of Heteroatom-Doped Carbon Dots-MnO-Based Nanosensor: Selective Detection of Glutathione in the Nanomolar Level.

Heteroatom doping on carbon dots (Cdots) has been developed as an efficient approach to modify its optical and electronic properties. The four different types of heteroatom-doped Cdots (undoped Cdots (u-Cdots, nitrogen-doped Cdots (N-Cdots), sulfur-doped Cdots (Cdots), nitrogen, sulfur codoped Cdots (N, S-Cdots)) have been synthesized through a simple heat treatment of 5 min. Among four different heteroatoms doped nanosensors, N, S-Cdots with MnO nanospheres (Mn NS) showed one of the best fluorescents "on-off-on" nanosensors for selective sensing of glutathione (GSH) and cell imaging.

Insulin-cobalt core-shell nanoparticles for receptor-targeted bioimaging and diabetic wound healing.

Diabetic wounds represent a major issue in medical care and need advanced therapeutic and tissue imaging systems for better management. The utilization of nano-formulations involving proteins like insulin and metal ions plays significant roles in controlling wound outcomes by decreasing inflammation or reducing microbial load. This work reports the easy one-pot synthesis of extremely stable, biocompatible, and highly fluorescent insulin-cobalt core-shell nanoparticles (ICoNPs) with enhanced quantum yield for their highly specific receptor-targeted bioimaging and normal and diabetic wound healing (HEKa cell line).

Production of a recyclable nanobiocatalyst to synthesize quinazolinone derivatives.

Nanobiocatalysts (NBCs) are an emerging innovation that paves the way toward sustainable and eco-friendly endeavors. In the quest for a robust and reusable nanobiocatalyst, herein, we report a nanobiocatalyst, namely CALB@MrGO, developed immobilizing lipase B onto the surface of FeO-decorated reduced graphene oxide (MrGO). Next, the enormous potential of the NBC (CALB@MrGO) was checked by employing it to synthesize clinically important quinazolinone derivatives in good to excellent yield (70-95%) using differently substituted aryl aldehydes with 2-aminobenzamide.

Protection of lead-induced cytotoxicity using paramagnetic nickel-insulin quantum clusters.

Pb-toxicity is associated with inflammation which leads to delay in wound healing. Pb utilizes calcium ion channels to enter the cell. Therefore, to achieve effective healing in a Pb-poisoned system, capturing Pb from the circulatory system would be an effective approach without hampering the activity of the calcium ion channel.

Tuning the photocatalytic/electrocatalytic properties of MoS/MoSe heterostructures by varying the weight ratios for enhanced wastewater treatment and hydrogen production.

Two-dimensional (2D) heterojunctions with layered structures give high flexibility in varying their photocatalytic/electrocatalytic properties. Herein, 2D/2D heterostructures of MoS/MoSe with different weight-ratios (1 : 1, 1 : 3, and 3 : 1) have been prepared by a simple one-step microwave-assisted technique. The characterization studies confirm formation of crystalline MoS/MoSe nanoparticles with a high surface area (60 m g) and porous structure.

Recent advances in heteroatom-doped graphene quantum dots for sensing applications.

Graphene quantum dots (GQDs) are carbon-based fluorescent nanomaterials having various applications due to attractive properties. But the low photoluminescence (PL) yield and monochromatic PL behavior of GQDs put limitations on their real-time applications. Therefore, heteroatom doping of GQDs is recognized as the best approach to modify the optical as well as electronic properties of GQDs by modifying their chemical composition and electronic structure.

Current progress, challenges and future prospects of indazoles as protein kinase inhibitors for the treatment of cancer.

The indazole core is an interesting pharmacophore due to its applications in medicinal chemistry. In the past few years, this moiety has been used for the synthesis of kinase inhibitors. Many researchers have demonstrated the use of indazole derivatives as specific kinase inhibitors, including tyrosine kinase and serine/threonine kinases.

Encapsulation and release of non-fluorescent crystal violet confined in bile-salt aggregates.

In this work, the entrapment of non-fluorescent dye Crystal Violet (CV) in presence of bio-mimetic confined bile-salt aggregates has been studied. The photophysical characteristic properties of CV have been carried out by changing different kinds of hydrophilic head groups and hydrophobic skeletons of bile-salt aggregates (NaC, NaDC, NaTC and NaTGC). The main aim of this work is to modulate the solubility behaviour, fluorescence properties and elucidation of different kinds of non-covalent interaction of CV confined in bile-salt aggregates.

ξ: An AI-Based Data Analytics Scheme for COVID-19 Prediction and Economy Boosting.

The coronavirus (COVID-19) outbreak has a significant impact on people's lives, occupations, businesses, and economies globally. The world economic market is experiencing a big shift and the share market has observed crashes day-by-day. Even, the Indian economy has witnessed a slowdown in the current pandemic, and recovery of it is quite difficult.

Label-free detection of creatinine using nitrogen-passivated fluorescent carbon dots.

In the field of biochemistry and biosensing, the passivation of carbon dots using nitrogen dopants has attracted great attention, as this can control their photoluminescence (PL) properties and quantum yield. To date, in the fabrication of a sensing probe, the impact of the chemical composition of the passivating molecule remained unexplored. In this work, we chose a series of different nitrogen-rich precursors (such as urea, thiourea, cysteine, and glycine) and ascorbic acid to synthesize nitrogen-doped carbon dots (NCDs).