gen. et sp. nov. (Mytilinidiaceae), and (Dactylosporaceae), a new lichenicolous species from Yunnan, China.

and are reported from China and identified through DNA sequence analyses (LSU, ITS, and 1-α) and morphological characteristics. Phylogenetic analysis showed that forms a distinct lineage within Mytilinidiaceae, closely related to the subclade, leading to the establishment of a new genus within this family. This saprotrophic species grows on the bark of , often surrounded by the thallus of species.

Animal models of post-acute COVID-19 syndrome: a call for longitudinal animal studies.

Animal models are indispensable for unraveling the mechanisms underlying post-acute sequelae of COVID-19 (PASC). This review evaluates recent research on PASC-related perturbations in animal models, drawing comparisons with clinical findings. Despite the limited number of studies on post-COVID conditions, particularly those extending beyond three months, these studies provide valuable insights.

Antibody responses in Burkinabe children against proteins associated with reduced risk of clinical malaria.

Individuals residing in malaria-endemic regions with high disease transmission can develop semi-immunity within five years of age. Although understanding the target of the IgGs in this age group helps discover novel blood-stage vaccine candidates and serological markers, it has not been well elucidated due to limited accessibility to plasmodial antigens and samples. This study presents the first comprehensive analysis of antibody levels in plasma obtained from Burkinabe children (n=80, aged 0 to 5 years) to 1307 proteins expressed by the eukaryotic wheat germ cell-free system.

Efficacy of Mild-to-Moderate Chronic Hand Eczema Treatment Using Petrolatum and Panthenol Ointment vs. 0.1% Triamcinolone Acetonide in 10% Urea Cream: A Split-hand, Evaluator-blinded, Randomized, Controlled Trial.

Background: There are many side effects resulting from the long-term use of conventional therapy (eg, high potency topical corticosteroids) for treatment of chronic hand eczema (CHE).

Objective: This study aimed to explore the efficacy of CHE treatment using the healing ointment (HO) of anti-inflammatory ingredients compared with 0.1% triamcinolone acetonide in 10% urea cream (TAU).

A global survey about undiagnosed rare diseases: perspectives, challenges, and solutions.

Background: Undiagnosed rare diseases (URDs) are a complex and multifaceted challenge, especially in low-and medium-income countries. They affect individuals with unique clinical features and lack a clear diagnostic label. Although the Undiagnosed Diseases Network International (UDNI) definition of URDs is not universally accepted, it is widely recognized.

The Differences in Necessary Competencies, Skills, and Performance Abilities Among Thai Board-Certified Occupational Medicine Physicians and Basic Occupational Medicine Certified Physicians.

Background: Occupational physicians in Thailand are classified into two groups: Thai board-certified occupational medicine physicians (TBOMPs) and Basic occupational medicine certified physician (BOMCPs). Variations in training duration result in differences in professional competencies. Although national regulations allow both groups to perform similar duties, disparities in training have raised concerns regarding competency, necessitating further investigation.

Phytochemical Analysis, Computational Study, and in vitro Assay of Inflorescence Extract Towards Inducible Nitric Oxide Synthase.

Background: Overproduction of nitric oxide (NO), catalyzed by inducible nitric oxide synthase (iNOS), in the gastric mucosa, contributes to the inflammatory process caused by oxidative stress. Current medications for gastric ulcers, such as proton pump inhibitors and histamine-2 receptor antagonists, have been reported to generate adverse reactions.

Purpose: To obtain the phytochemical profile of inflorescence extract, computational studies, and in vitro assay of the extract towards iNOS.

Improved genetic screening with zygosity detection through multiplex high-resolution melting curve analysis and biochemical characterisation for G6PD deficiency.

Accurate diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is crucial for relapse malaria treatment using 8-aminoquinolines (primaquine and tafenoquine), which can trigger haemolytic anaemia in G6PD-deficient individuals. This is particularly important in regions where the prevalence of G6PD deficiency exceeds 3%-5%, including Southeast Asia and Thailand. While quantitative phenotypic tests can identify women with intermediate activity who may be at risk, they cannot unambiguously identify heterozygous females who require appropriate counselling.

Machine Learning Assisted for Preparation of Graphene Supported Cu-Zn Catalyst for CO2 Hydrogenation to Methanol.

Graphene has emerged as a promising support material for Cu-Zn catalysts in CO2 hydrogenation to methanol due to its high surface area and potential for functionalization with heteroatoms like nitrogen and oxygen, with nitrogen believed to contribute to the reaction. In this study, we combined machine learning and data analysis with experimental work to investigate this effect. Machine learning (using a decision tree model) identified copper particle size, average pore diameter, reduction time, surface area, and metal loading content as the most impactful features for catalyst design, while nitrogen doping showed negligible influence on methanol space-time yield.

Characterization of treatment intensified (add-on to metformin) adults with type 2 diabetes in Thailand: A cross-sectional real-world study (CONVERGE).

Objective: The CONVERGE (Cardiovascular Outcomes and Value in the Real-World with GLP-1RAs) study characterized demographics, clinical characteristics, and medication use in treatment-intensified (add-on to metformin) adults with type 2 diabetes (T2D) in Thailand.

Methods: A retrospective cross-sectional study of data from medical records (Jul 26, 2013, to Dec 31, 2017) was descriptively summarized for overall population and subgroups defined by glucose-lowering agent (GLA) classes.

Results: Data from 1,000 adults were collected in reverse chronological order.

Bisphenol A Biomonitoring after Sealant Placement: A Prospective Cohort Study in Schoolchildren.

Introduction: Bisphenol A (BPA), known for its endocrine-disrupting properties, is a concern when leaching from dental sealants. This study investigates the systemic BPA exposure following the placement of Bis-GMA-based dental sealants in Thai primary school students.

Objectives: The main objective was to evaluate the changes in urinary BPA concentrations after the application of Bis-GMA dental sealants in a cohort of Thai students.

Bacteriocins from Lactic Acid Bacteria Could Modulate the Wnt Pathway: A Possible Therapeutic Candidate for the Management of Colorectal Cancer- An In silico Study.

Introduction: Colorectal cancer (CRC) is a type of cancer that develops due to abnormal cell growth in the colon and rectum. Existing conventional CRC treatment strategies have side effects. Hence, exploring new and advanced techniques for bacterial CRC therapy is crucial.

Exploring Antioxidant Properties of Standardized Extracts from Medicinal Plants Approved by the Thai FDA for Dietary Supplementation.

Background/objectives: There is a growing interest in plant-derived antioxidants as functional food ingredients, given their potential to address oxidative stress-related diseases, notably neurodegenerative disorders. This study aims to investigate the antioxidant properties of medicinal plants that have been approved by the Thai FDA for dietary supplementation, with the goal of further utilizing them as food-functional ingredients to prevent neurodegenerative conditions.

Methods: A systematic review-based methodology was employed on a list of 211 medicinal plants, and 21 medicinal plants were chosen based on their documented antioxidant activity and acetylcholinesterase (AChE) inhibitory capacity.

Camellia Tea Saponin Ameliorates 5-Fluorouracil-Induced Damage of HaCaT Cells by Regulating Ferroptosis and Inflammation.

Background/objective: Ferroptosis is an iron-dependent form of programmed cell death characterized by lipid peroxidation products (LPOs). A chemotherapeutic drug, 5-fluorouracil (5-FU), can induce epithelial mucositis and favor drug synergism with erastin in ferroptosis. tea saponin extract (TS) is known to exert antioxidative properties.

Synergistic Neuroprotection Through Epigenetic Modulation by Combined Curcumin-Enriched Turmeric Extract and L-Ascorbic Acid in Oxidative Stress-Induced SH-SY5Y Cell Damage.

Epigenetic modulation plays a crucial role in neuroprotection by regulating cellular responses to stress, inflammation, and oxidative damage, particularly in neurodegenerative diseases. Recognizing the therapeutic potential of epigenetic regulators, this study investigated the synergistic neuroprotective effects of curcumin-enriched turmeric extract combined with L-ascorbic acid, focusing on its modulation of epigenetic pathways in oxidative stress-induced neuronal damage. SH-SY5Y neuronal cells were treated with the combination at 20 and 40 µg/mL, and subsequently exposed to 200 µM hydrogen peroxide (HO) to induce oxidative stress.

Physicochemical, Volatile Compound Profile, Antioxidant, and Cytotoxic Activities of Northeastern Thai Ethnic Ready-to-Serve Food Pastes Jaew Hon and Gang Om: A Comparative Study of Laboratory and Industrial Production Processes.

Northeastern Thai ethnic foods are celebrated for their health benefits yet remain largely underexplored. This study assessed the antioxidant and cytotoxic properties of two ready-to-eat pastes-Jaew Hon (JH) and Gang Om (GO)-produced using laboratory (LAB) and industrial original equipment manufacturer (OEM) methods. Evaluations were conducted using 2,2-Diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), total phenolic content (TPC), and total flavonoid content (TFC) assays alongside the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for cytotoxicity.

Black Gram ( L.) Husk as a Source of Bioactive Compounds: An Evaluation of Starch Digestive Enzyme Inhibition Effects.

This research recovered bioactive compounds from black gram husk (BGH, a by-product of sprout processing) using different ethanol concentrations and maceration times. Based on the results, the highest phenolic and saponin contents were recovered using an 80% ethanolic solution for 3 h, with the extract having both antioxidant and starch digestive enzyme inhibition effects. The major bioactive compounds present in the extract were gallic acid, gentisic acid, ferulic acid, and vitexin.

Immunoglobulin Y-Based Lateral Flow Immunoassay Strip Test for Detecting Ciprofloxacin Antibiotic in Raw Pork Samples.

Ciprofloxacin is metabolized from enrofloxacin for use in poultry to manage respiratory and gastrointestinal diseases, raising concerns due to its widespread tissue distribution and prolonged systemic persistence. This lateral flow immunoassay was designed to detect ciprofloxacin using an alternative IgY antibody binded with gold nanoparticles to detect ciprofloxacin residue in raw pork meat samples. The developed strip test achieved adequate sensitivity and specificity under the optimized conditions for pH, which is 7.

Integrating Microalgal Biomass and Biorefinery Residues into Sustainable Agriculture and Food Production: Insights from Lettuce Cultivation.

Microalgal biomass offers a promising biofertilizer option due to its nutrient-rich composition, adaptability, and environmental benefits. This study evaluated the potential of microalgal-based biofertilizers-microalgal biomass, de-oiled microalgal biomass (DMB), and de-oiled and de-aqueous extract microalgal biomass (DAEMB)-in enhancing lettuce growth, soil nutrient dynamics, and microbial community composition. Lettuce seedlings were cultivated with these biofertilizers, and plant growth parameters, photosynthetic pigments, and nitrogen uptake were assessed.

Development of Bioactive Edible Film and Coating Obtained from sp. Extract Applied for Enhancing Shelf Life of Fresh Products.

The growing interest in environmentally friendly food packaging has led to the development of bio-edible alternatives. This study developed novel, edible, active films and coatings to enhance the shelf life of fresh products. Crude bioactive algal extract (CBAE) was obtained from the ethanol extraction of sp.

Panduratin A from Effectively Inhibits EGFR/STAT3/Akt Signaling Pathways, Inducing Apoptosis in NSCLC Cells with Wild-Type and T790M Mutations in EGFR.

Non-small cell lung cancer (NSCLC) is a challenging disease, with the epidermal growth factor receptor (EGFR) being a key target for new, effective treatments crucial for the signaling pathways regulating cancer cell survival. Targeting EGFR-mediated signaling offers promising strategies to improve NSCLC therapies, particularly in overcoming resistance in EGFR-mutant lung cancer. In this study, we investigated the anticancer effects of panduratin A, a naturally occurring flavonoid from , on human NSCLC cell lines expressing both wild-type EGFR (A549) and mutant EGFR (H1975) using in vitro experiments and molecular docking approaches.

Temporal Transcriptomic Analysis of Periodontal Disease Progression and Its Molecular Links to Systemic Diseases.

Periodontal disease, a prevalent oral inflammatory condition, is implicated in exacerbating systemic diseases. However, the molecular mechanisms underlying this association remain unclear. In this study, we performed RNA sequencing of gingival tissue samples collected from a mouse model of periodontal disease at multiple time points to investigate dynamic transcriptomic changes during disease progression.

Agomelatine Mitigates Kidney Damage in Obese Insulin-Resistant Rats by Inhibiting Inflammation and Necroptosis via the TNF-α/NF-ĸB/p-RIPK3 Pathway.

Obesity is a risk factor for chronic kidney disease. The expansion of adipose tissues in obesity induces insulin resistance and low-grade systemic inflammation, promoting kidney damage. Our previous studies have demonstrated that agomelatine (AGOM) exerts renoprotective effects in experimental models of obesity and insulin resistance through various mechanisms, including the attenuation of ER stress and oxidative stress.

L. Leaf Oil Displays Cardiovascular Protective Effects in Hypertensive Rats.

Hemp ( L.) leaf oil (HLO) contains several bioactive compounds such as phenolics, flavonoids, and quercetin. However, the effects of HLO on hypertensive conditions have not yet been investigated.