Short-Term Safety of Nutri-Jelly in Adults Undergoing Hemodialysis.

Excessive water consumption from liquid or reconstituted oral nutrition supplements may increase risk of fluid overload in renal patients. Nutri-jelly, a ready-to-eat texture-modified diet with 52.8% water, some protein, low potassium, phosphorus, and sodium, could be an alternative.

Benzaldehyde and azaphilone derivatives from the marine-derived fungus PSU-AMF89.

Two new compounds including one benzaldehyde () and one azaphilone () were isolated from the marine-derived fungus PSU-AMF89 together with nine known compounds (-). Their structures were determined by spectroscopic evidences. The absolute configuration of was established by comparison of the ECD data with those of the previously reported data of compound as well as the biosynthetic consideration.

A dual antioxidant and antimicrobial bioplastic film endowed with amine-branched poly(lactic acid): Bioactive packaging for electron beam sterilization and food shelf-life extension.

Cyclic amine-multibranched poly(lactic acid) (mPLA) was prepared as a dual antioxidant and antimicrobial toward PLA active packaging for food shelf-life extension in a case study of bread. The mPLA was coupled with piperidine (PPR) containing a heterocyclic amine derivative, which is a nature-rich bioactive function. The functions of mPLA-PPR enhancing the PLA film performance were studied in comparison with PPR, mPLA and Tinuvin® 770.

Early engraftment and immune kinetics following allogeneic transplant using a novel reduced-toxicity transplant strategy in children/adolescents with high-risk transfusion-dependent thalassemia: Early results of the ThalFAbS trial.

Background: Allogeneic transplant for patients with transfusion-dependent thalassemia is challenging once there has been iron overload and chronic transfusion support.

Objective(s): A transplant strategy that reduced intensity of the preparative regimen and tailored immunosuppression to both support donor engraftment and prevent GVHD was developed for this population. The combination of a pretransplant immunosuppression phase with reduced dosing of fludarabine/prednisone, treosulfan-based preparative regimen with reduced cyclophosphamide dosing, and introduction of a calcineurin/methotrexate-free GVHD prophylaxis/engraftment supporting regimen with abatacept/sirolimus/ATG was tested.

A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly.

Background And Objectives: The pharmacokinetics (PK) of piperacillin/tazobactam (PIP/TAZ) is highly variable across different patient populations and there are controversies regarding non-linear elimination as well as the fraction unbound of PIP (f). This has led to a plethora of subgroup-specific models, increasing the risk of misusing published models when optimising dosing regimens. In this study, we aimed to develop a single model to simultaneously describe the PK of PIP/TAZ in diverse patient populations and evaluate the current dosing recommendations by predicting the PK/pharmacodynamics (PD) target attainment throughout life.

The morphological dietary preferences of an outbreaking population of corallivorous crown-of-thorns sea stars (Acanthaster sp.) in the Gulf of Thailand.

The current study investigated the morphological dietary preferences of an outbreaking population of corallivorous crown-of-thorn sea stars (Acanthaster sp.) in Koh Tao, situated in the Gulf of Thailand. The local effects of such populations deemed to be in outbreak are currently poorly understood.

Malaria elimination challenges in countries approaching the last mile: a discussion among regional stakeholders.

Background: The national malaria control programmes in Cambodia, Nepal, and Bhutan aim to achieve malaria elimination by 2025-2030. While the vivax malaria burden remains challenging, the consistent decline in falciparum malaria in these countries over the last five years suggests that the goal is achievable. However, unexpected cases in previously falciparum malaria-free districts continue to occur.

Osteogenic Induction Activity of Magnesium Chloride on Human Periodontal Ligament Stem Cells.

Objectives: Periodontal ligament stem cells (PDLSCs) are promising for regenerative therapies due to their self-renewal and multilineage differentiation, essential for periodontal tissue repair. Although magnesium plays a vital role in bone metabolism, its specific effects on PDLSCs and potential applications in regeneration are unclear. This study aimed to investigate the effects of magnesium chloride (MgCl₂) on the proliferation and osteogenic differentiation of human PDLSCs (hPDLSCs).

Novel hydroxy naphthol blue-based recombinase polymerase amplification for the rapid detection of Staphylococcus pseudintermedius.

Staphylococcus pseudintermedius (S. pseudintermedius) is a significant cause of pyoderma, soft tissue, urinary tract, and ear infections in cats and dogs. Bacterial culture and biochemical phenotypic assays are the gold standards for clinical diagnosis of bacteria but molecular methods have now been developed to identify and differentiate S.

Prevalence and characteristics of microplastic contamination in soft drinks and potential consumer exposure.

Microplastics (MPs) contamination in human food is a growing concern due to potential health risks. Recent studies have indicated that MPs have been found in various human tissues and organs, including the placenta, lungs, liver, and blood. This highlights the importance of investigating the presence and concentration of MPs in food products, as it directly relates to human health and safety.

Effective control of snake fruit (Salacca zalacca) rot using Trichoderma asperelloides SKRU-01: A safe approach to preserving fruit quality.

Rot disease, caused by the fungal pathogen Peniophora salaccae SKRU002, affects the quality of snake fruit production. In the pursuit of sustainable disease management, biocontrol using Trichoderma asperelloides SKRU-01 offers a promising solution. This study evaluated the antagonistic potential of T.

Five new species, two new sexual morph reports, and one new geographical record of (Amphisphaeriales, Sordariomycetes) isolated from bamboo in Yunnan, China.

is an important genus in the Apiosporaceae family with a worldwide distribution. They exhibit different lifestyles including pathogenic, saprophytic, and endophytic. In this study, we aimed to explore the associated with bamboo and collected 14 apiospora-like taxa from the forests of Yunnan Province, China.

Efficacy and Safety of Transdermal Medical Cannabis (THC:CBD:CBN formula) to Treat Painful Diabetic Peripheral Neuropathy of Lower Extremities.

Introduction: Diabetic peripheral neuropathy (DPN) represents a prevalent neurological complication affecting millions of patients globally. This clinical investigation evaluated the therapeutic efficacy and safety profile of a novel transdermal medical cannabis formulation (THC:CBD:CBN) in treating painful DPN of the lower extremities.

Methods: This phase III, double-blind, placebo-controlled, randomized clinical trial was conducted at Don Chan Hospital, Thailand, enrolling 100 participants over a 12-week intervention period.

Continuous tremor monitoring in Parkinson's disease: A wristwatch-inspired triboelectric sensor approach.

Parkinson's disease (PD) prevalence is projected to reach 12 million by 2040. Wearable sensors offer a promising approach for comfortable, continuous tremor monitoring to optimize treatment strategies. Here, we present a wristwatch-like triboelectric sensor (WW-TES) inspired by automatic watches for unobtrusive PD tremor assessment.

Black rice bran‑derived anthocyanins attenuate cholangiocarcinoma cell migration via the alteration of epithelial‑mesenchymal transition and sialylation.

Cholangiocarcinoma (CCA) is an aggressive cancer of the bile duct epithelium. Anthocyanins are water-soluble flavonoids that contribute to the color of fruits and pigmented rice. Black rice bran is rich in anthocyanin pigments and exhibits certain health benefits, including anticancer activity; however, the effect of black rice bran-derived anthocyanins (BBR-M-10) on CCA progression remains unclear.

Impact of Perampanel for First-Episode Seizures versus Usual Care on Clinical Outcome and Safety Profile Aspects of the Thai Experience.

Background And Purpose: Epilepsy increases poor outcomes in patients with post-traumatic brain injury and brain tumor-related epilepsy, for whom early seizure control is essential. Perampanel (PER) was a known third-generation antiepileptic drug for treatment all types of seizures. The objective of the study is to compare clinical outcomes and safety of PER administration as monotherapy.

Impact of telehealth-based therapeutic exercise on pain, functional performance and dynamic knee valgus in young adult females with patellofemoral pain: a randomised controlled trial.

Objectives: This study aimed to evaluate the effectiveness of a telehealth-based therapeutic exercise (TTE) programme with real-time video conference supervision for young adult females with patellofemoral pain (PFP).

Methods: The study design was a randomised controlled trial. Forty-two participants with PFP were allocated to either the TTE group or the control (C) group.

Relationship between official visits, industry chain coordination and digital transformation in China.

With digital transformation becoming a global consensus, governments around the world are vigorously promoting the implementation of enterprise digital transformation. However, there are some uncertainties in the process of digital transformation, and companies have overlooked the role of formal access. To better understand the role official visits play in digital transformation, based on signal theory, the study examines the influence of official visits on corporate digitalization using data from listed SMEs in China from 2017 to 2021.

Impact of AI on the Cyber Kill Chain: A Systematic Review.

The Cyber Kill Chain (CKC) defense model aims to assist subject matter experts in planning, identifying, and executing against cyber intrusion activity, by outlining seven stages required for adversaries to execute an attack. Recent advancements in Artificial Intelligence (AI) have empowered adversaries to execute sophisticated attacks to exploit system vulnerabilities. As a result, it is essential to consider how AI-based tools change the cyber threat landscape and affect the current standard CKC model.

Functional kombucha production from fusions of black tea and Indian gooseberry ( L.).

The use of alternative ingredients as supplements to or blends with kombucha tea to improve organoleptic properties and health effects has recently increased. Indian gooseberry fruit is among the most promising alternative raw materials for producing functional kombucha since the berries contain several beneficial substances. In this study, the production of functional kombucha beverages from fusions of black tea and Indian gooseberry fruit homogenate (IGH) was investigated, and the chemical and biological properties of kombucha products were evaluated and compared with those of traditional black tea kombucha products.

Influence of three antiseptic mouthwashes on microtensile bond strength of self-etch adhesive to dentin: Rinsing versus non-rinsing with water.

Objective: The purpose of this study was to examine the effect of several antiseptic mouthwashes on the dentin microtensile bond strength of self-etch adhesive, considering the influence of rinsing with water.

Methods: Forty flat dentin surfaces were produced by sectioning sound extracted third molars. They were randomly divided into four main groups: (1) artificial saliva (control); (2) 1 % hydrogen peroxide; (3) 0.

MolecularWebXR: Multiuser discussions in chemistry and biology through immersive and inclusive augmented and virtual reality.

MolecularWebXR is a new web-based platform for education, science communication and scientific peer discussion in chemistry and biology, based on modern web-based Virtual Reality (VR) and Augmented Reality (AR). With no installs as it is all web-served, MolecularWebXR enables multiple users to simultaneously explore, communicate and discuss concepts about chemistry and biology in immersive 3D environments, by manipulating and passing around objects with their bare hands and pointing at different elements with natural hand gestures. Users may either be present in the same physical space or distributed around the world, in the latter case talking naturally with each other thanks to built-in audio.

VI steps to achieve VI-RADS assessment.

Bladder cancer is categorized into nonmuscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC), distinguished by the presence of detrusor muscle invasion. Urothelial cell carcinoma is the most common subtype of bladder cancer. Transurethral resection of bladder tumor (TURBT) is the standard approach for staging and managing NMIBC, while radical cystectomy remains the cornerstone treatment for MIBC.

Fractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery: impact of triamcinolone acetonide formulation on drug permeation.

Ablative fractional laser-assisted drug delivery has gained attention as a promising method for enhancing dermal drug absorption and improving therapeutic outcomes in dermatological conditions, particularly for hypertrophic and keloid scars. However, despite the growing number of clinical trials and case reports supporting its efficacy, there remains a scarcity of robust evidence on the topical bioavailability and dermato-pharmacokinetics of drugs in human subjects. This study aimed to examine the enhancement of triamcinolone acetonide (TAC) bioavailability following treatment with a fractional Erbium-Doped Yttrium Aluminum Garnet (Er: YAG) laser.