132,138 results match your criteria: "Thailand; Centre of Excellence on Energy Technology and Environment[Affiliation]"

Vernonolide A, a Sesquiterpene Lactone with a Unique Carbon Skeleton from .

Org Lett

January 2025

Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, Hawai'i 96720, United States.

A novel sesquiterpene lactone derivative, vernonolide A (), featuring an unprecedented carbon skeleton, along with its plausible biosynthetic precursor, vercinolide I (), and eight known sesquiterpene lactones (-) were isolated and characterized from the whole plants of (L.). The structures of and were elucidated using nuclear magnetic resonance spectroscopic analysis and calculated and experimental electronic circular dichroism spectra.

View Article and Find Full Text PDF

Synthetic rational design of live-attenuated Zika viruses based on a computational model.

Nucleic Acids Res

January 2025

SynVaccine Ltd, Ramat Hachayal, 3 Golda Meir Street, Science Park, Nes Ziona 7403648, Israel.

Many viruses of the Flaviviridae family, including the Zika virus (ZIKV), are human pathogens of significant public health concerns. Despite extensive research, there are currently no approved vaccines available for ZIKV and specifically no live-attenuated Zika vaccine. In this current study, we suggest a novel computational algorithm for generating live-attenuated vaccines via the introduction of silent mutation into regions that undergo selection for strong or weak local RNA folding or into regions that exhibit medium levels of sequence conservation.

View Article and Find Full Text PDF

The case report presents a male patient in his mid-60s with a history of hypertension, benign prostatic hyperplasia and chronic kidney disease (CKD). He presented with gradually increasing serum creatinine levels and hyperglobulinemia, leading to suspicion of multiple myeloma. However, subsequent testing revealed features consistent with systemic lupus erythematosus (SLE) and IgG4-related kidney disease (IgG4-RKD).

View Article and Find Full Text PDF

Background: Patients with serious mental illness (SMI) often engage in religious and superstitious activities. The implications of such engagements remain unclear, with no established guidelines for mental health professionals.

Aims: This study aimed to survey perspectives and gather suggestions from various disciplines within mental healthcare regarding the engagement in religious/superstitious activities of SMI patients: schizophrenia spectrum disorders, bipolar disorder, major depressive disorder.

View Article and Find Full Text PDF

Background: Edible insects are used for consumption and traditional medicine due to their rich bioactive compounds. This study examined the bioactive compounds and inhibitory effects of crude extracts from Bombyx mori and Omphisa fuscidentalis on α-glucosidase, α-amylase, acetylcholinesterase (AChE), and tyrosinase. Fatty acids, including n-hexadecanoic acid and oleic acid, were identified in the extracts and evaluated for their inhibitory potential against the enzymes in vitro and in silico.

View Article and Find Full Text PDF

Self-Sustained Biophotocatalytic Nano-Organelle Reactors with Programmable DNA Switches for Combating Tumor Metastasis.

Adv Mater

January 2025

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, P. R. China.

Metastasis, the leading cause of mortality in cancer patients, presents challenges for conventional photodynamic therapy (PDT) due to its reliance on localized light and oxygen application to tumors. To overcome these limitations, a self-sustained organelle-mimicking nanoreactor is developed here with programmable DNA switches that enables bio-chem-photocatalytic cascade-driven starvation-photodynamic synergistic therapy against tumor metastasis. Emulating the compartmentalization and positional assembly strategies found in living cells, this nano-organelle reactor allows quantitative co-compartmentalization of multiple functional modules for the designed self-illuminating chemiexcited PDT system.

View Article and Find Full Text PDF

Dasatinib and Quercetin Limit Gingival Senescence, Inflammation, and Bone Loss.

J Dent Res

January 2025

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Cellular senescence has emerged as one of the central hallmarks of aging and drivers of chronic comorbidities, including periodontal diseases. Senescence can also occur in younger tissues and instigate metabolic alterations and dysfunction, culminating in accelerated aging and pathological consequences. Senotherapeutics, such as the combination of dasatinib and quercetin (DQ), are being increasingly used to improve the clinical outcomes of chronic disorders and promote a healthy life span through the reduction of senescent cell burden and senescence-associated secretory phenotype (SASP).

View Article and Find Full Text PDF

Inclusion of Black Soldier Fly Larval Oil in Ruminant Diets Influences Feed Consumption, Nutritional Digestibility, Ruminal Characteristics, and Methane Estimation in Thai-Indigenous Steers.

J Anim Physiol Anim Nutr (Berl)

January 2025

Tropical Feed Resources Research and Development Center (TROFREC), Department of Animal Science, Faculty of Agriculture, Khon Kaen University, Khon Kaen, Thailand.

The objective of this study was to examine the impact of black soldier fly larval oil (BSFO) on feed consumption, nutritional digestibility, ruminal characteristics and methane (CH) estimation in Thai-indigenous steers. Four male Thai native steers (Bos indicus) weighing 383 ± 9.0 kg were used in this investigation.

View Article and Find Full Text PDF

Injuries involving the Atlas (C1) and Axis (C2) vertebrae of the cervical spine present significant clinical challenges due to their complex anatomy and potential for severe neurological impairment. Traditional imaging methods often lack the detailed visualization required for precise surgical planning. This study aimed to develop high-resolution 3D models of the C1 and C2 vertebrae to perform a comprehensive morphometric analysis, identify gender differences, and assess bilateral symmetry to enhance surgical accuracy.

View Article and Find Full Text PDF

: Attaining adequate oxygenation in critically ill patients undergoing invasive ventilation necessitates intense monitoring through pulse oximetry (SpO) and frequent manual adjustments of ventilator settings like the fraction of inspired oxygen (FiO) and the level of positive end-expiratory pressure (PEEP). Our aim was to compare the quality of oxygenation with the use of automated ventilation provided by INTELLiVENT-Adaptive Support Ventilation (ASV) vs. ventilation that is not automated, i.

View Article and Find Full Text PDF

Chronic stress exposure has been widely recognized as a significant contributor to numerous central nervous system (CNS) disorders, leading to debilitating behavioral changes such as anxiety, depression, and cognitive impairments. The prolonged activation of the hypothalamic-pituitary-adrenal (HPA) axis during chronic stress disrupts the neuroendocrine balance and has detrimental effects on neuronal function and survival. () Gaertn.

View Article and Find Full Text PDF

Efficacy of Natural β-Carotene Chewable Tablets Derived from Banana ( AA) Pulp in Reducing UV-Induced Skin Erythema.

Nutrients

December 2024

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.

Background/objectives: UV radiation is a primary cause of skin damage and photoaging. β-carotene, a potent antioxidant, aids in mitigating UV-induced oxidative stress and enhancing skin photoprotection. This research aimed to evaluate the efficacy of a nutraceutical product designed to prevent photoaging.

View Article and Find Full Text PDF

Comparative Analysis of Biochemical Parameters, Thermal Behavior, Rheological Features, and Gelling Characteristics of Thai Ligor Hybrid Chicken and Broiler Meats.

Foods

December 2024

Food Technology and Innovation Research Center of Excellence, School of Agricultural Technology and Food Industry, Walailak University, Nakhon Si Thammarat 80160, Thailand.

Genetic differences typically cause differences in the structure and function of proteins in meat. The objective of this research was to examine the biochemical characteristics and functional behavior of proteins in fresh composite meat from Thai Ligor hybrid chicken (LC) and commercial broiler chicken (BC). The composite meat samples, which comprise minced breast and thigh without skin from 20 chicken carcasses in a 1:1 (/) ratio, were randomly selected for analysis using the completely randomized design (CRD).

View Article and Find Full Text PDF

We investigated the accuracy of predicting preload responsiveness by means of a passive leg raising test (PLR) using the perfusion index (PI) in critically ill patients showing signs of hypoperfusion in a resource-limited setting. We carried out a prospective observational single center study in patients admitted for sepsis or severe malaria with signs of hypoperfusion in Chattogram, Bangladesh. A PLR was performed at baseline, and at 6, 24, 48, and 72 h.

View Article and Find Full Text PDF

Non-Invasive Biomarkers and Breath Tests for Diagnosis and Monitoring of Chronic Liver Diseases.

Diagnostics (Basel)

December 2024

Pediatric Liver Center, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Chronic liver disease (CLD) presents a significant global health burden, demanding effective tools for diagnosis and monitoring. Traditionally, liver biopsy has been the gold standard for evaluating liver fibrosis and other chronic liver conditions. However, biopsy's invasiveness, associated risks, and sampling variability indicate the need for reliable, noninvasive alternatives.

View Article and Find Full Text PDF

The accurate staging of liver fibrosis is crucial for managing chronic liver disease (CLD). Although magnetic resonance elastography (MRE) is the reference standard for noninvasive fibrosis assessment, its cost, specialized hardware, and operational demands restrict accessibility. In contrast, two-dimensional shear-wave elastography (2D-SWE) is more affordable, accessible, and widely integrated into routine ultrasound systems.

View Article and Find Full Text PDF

This study investigates the development of epoxy-resin composites reinforced with coral-derived calcium carbonate (CaCO) fillers for enhanced radiation shielding and mechanical properties. Leveraging the high calcium content and density of coral, composites were prepared with filler weight fractions of 0%, 25%, and 50%. SEM and EDS analyses revealed that higher filler concentrations (50%) increased particle agglomeration, affecting matrix uniformity.

View Article and Find Full Text PDF

Enhancing Mechanical and Antibacterial Performance of Tire Waste/Epoxidized Natural Rubber Blends Using Modified Zinc Oxide-Silica.

Polymers (Basel)

January 2025

Sustainable Polymer & Innovative Composite Materials Research Group, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand.

This study investigates the synergistic effects of incorporating modified zinc oxide-silica (ZnO-SiO) into tire waste (TW) and epoxidized natural rubber (ENR) blends, with a focus on crosslinking dynamics, mechanical reinforcement, and antibacterial activity. The addition of ZnO-SiO significantly enhanced crosslink density, as evidenced by increased torque and accelerated cure rates. An optimal concentration of 10 phr was found to yield the highest performance.

View Article and Find Full Text PDF

Dye Adsorbent from Natural Rubber Latex Foam: Efficiency and Post-Utilization.

Polymers (Basel)

January 2025

Department of Rubber Technology and Polymer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Pattani 94000, Thailand.

This study examined the feasibility of using natural rubber (NR) latex foam as a dye adsorbent and antibacterial foam. The dyes used in this experiment were Methylene Blue (MB) and Alizarin Yellow (AY). Foams with that optimum density were further evaluated for adsorption isotherm, kinetics, and thermodynamic data.

View Article and Find Full Text PDF

Hybrid Natural Fiber Composites of Polylactic Acid Reinforced with Sisal and Coir Fibers.

Polymers (Basel)

December 2024

Department of Industrial Engineering, School of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok 10520, Thailand.

This study explored the tensile and impact strength of polylactic acid (PLA) through the incorporation of sisal and coir fibers. Hybrid natural fiber composites were prepared using PLA as the matrix and sisal and coir fibers as the reinforcements. The hybrid composites were prepared with an internal mixer, followed by compression molding.

View Article and Find Full Text PDF

Nanocomposites based on metal nanoparticles (MNP) prepared with mangosteen () peel extract-mediated biosynthesis of Ag/Zn have attracted considerable interest due to their potential for various practical applications. In this study, their role in developing antibacterial protection for rubber cotton gloves is investigated. The process of mangosteen-peel-extract-mediated biosynthesis produced Ag/Zn nanocomposites with respective diameters of 23.

View Article and Find Full Text PDF

Methyl Gallate and Amoxicillin-Loaded Electrospun Poly(vinyl alcohol)/Chitosan Mats: Impact of Acetic Acid on Their Anti- Activity.

Polymers (Basel)

December 2024

Materials Technology Program, School of Energy, Environment and Materials, King Mongkut's University of Technology Thonburi, 126 Pracha Uthit Road, Bang Mod, Bangkok 10140, Thailand.

Methyl gallate (MG), a natural phenolic compound, exhibits in vitro synergistic activity with amoxicillin (Amox) against methicillin-resistant (MRSA), a global health concern. This study developed electrospun nanofibers incorporating MG and Amox into a poly(vinyl alcohol) (PVA)/chitosan (CS) blend to target both methicillin-susceptible (MSSA) and MRSA. The formulation was optimized, and the impact of acetic acid on antibacterial activity was evaluated using agar disc diffusion.

View Article and Find Full Text PDF

Strawberries are valued globally for their nutritional, aesthetic, and economic benefits. Optimizing blue-to-red LED ratios and nitrogen levels is essential for sustainable indoor strawberry cultivation. This factorial study investigated the effects of blue and red LED combination ratios (L1; 1:3, L2; 1:4, and L3; 1:6) and nitrogen levels (N1; 100 and N2; 200 mg/L) on the physiology and performance of strawberries in a plant factory.

View Article and Find Full Text PDF

Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to choline metabolism. The present study investigated the effect of holy basil ( L.) flower water extract (OSLY) on MASLD with choline metabolism as an underlying mechanism.

View Article and Find Full Text PDF

Porcine epidemic diarrhea (PED) virus is an important cause of diarrhea in sows and piglets [...

View Article and Find Full Text PDF