A systematic review of circulating IP-10/CXCL10 in patients with Plasmodium infections in relation to disease severity.

Interferon γ-induced protein 10 kDa (IP-10) or C-X-C motif chemokine 10 (CXCL10) is produced and secreted from specific leukocytes such as neutrophils, eosinophils, and monocytes, which play key roles in the immune response to Plasmodium infections. This systematic review aimed to collate and critically appraise the current evidence on IP-10 levels in malaria patients. It provided insights into its role in malaria pathogenesis and potential as a biomarker for Plasmodium infections and disease severity.

Accurate calculation of the content volume, density and original weight of museum curated eggs.

Worldwide museums hold collections of eggshells representing material for descriptive studies. However, an obstacle to this is the lack of information about the original contents and weight of the entire egg (W). This study aimed to fill this gap though development of a methodological mechanism for calculating the volume of the egg interior (V), its density (D) and W.

Characteristics of compression wave propagation and energy absorption effects in dry sandy soil.

The mechanical responses of sandy soil under dynamic loading is closely related to protective engineering and geotechnical engineering, is still not fully understood. To investigate the energy attenuation law and propagation velocity of compressed waves in dry sandy soil, this paper focuses on the dynamic response of compression waves in the specimen under single impact and repetitive impact conditions using an improved split Hopkinson pressure bar (SHPB). The results reveal that the length of the specimen follows an exponential relationship with the attenuation of the peak stress.

Sustainability study and SWOT analysis of mixed biofuel blends in engine at various injection pressure analysed by experimentally and statistically.

This study aims to reduce engine emissions while maintaining engine performance and providing a sustainable fuel source for long-term use. It introduces a novel approach by combining pine oil (PO) and lemon grass oil (LGO) with diesel fuel in a specific ratio (10% PO + 10% LGO + 80% Diesel). This work is innovative in that it employs these two distinct low-viscosity biofuel blends in conjunction with diesel fuel in an agricultural engine, resulting in reduced carbon footprints in the tailpipe.

A new type III effector from Bradyrhizobium sp. DOA9 encoding a putative SUMO-protease blocks nodulation in Arachis hypogaea L.

Effector proteins secreted via the type III secretion system (T3SS) of nitrogen-fixing rhizobia are key determinants of symbiotic compatibility in legumes. Previous report revealed that the T3SS of Bradyrhizobium sp. DOA9 plays negative effects on Arachis hypogaea symbiosis.

Prevalence of burnout and its determinants among Indonesian nurses: a multicentre study.

Frontline health workers face a significant issue concerning mental health, particularly stress and burnout. Nurses, being among them, grapple with this problem. The study aims to investigate the prevalence and determinants of burnout among nurses.

Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility.

Plasmodium malariae parasites are widely observed across the tropics and sub-tropics. This slow-growing species, known to maintain chronic asymptomatic infections, has been associated with reduced antimalarial susceptibility. We analyse 251 P.

Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance.

Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions have led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine instead. However, the molecular drivers of CQR remain unclear. Using a genome-wide approach, we perform a genomic analysis of 1534 P.

Low-Dose Emicizumab Versus Low-/Intermediate-Dose Factor VIII Secondary Prophylaxis for Noninhibitor Haemophilia A Patients With Severe Bleeding Phenotype.

Background: Subcutaneous emicizumab, a factor VIII (FVIII)-mimicking bispecific monoclonal antibody, can effectively prevent bleeds in haemophilia A (HA) patients with/without inhibitors; however, its standard-dose regimens are financially burdensome. Low-dose emicizumab prophylaxis may alternatively be applied to noninhibitor HA patients in resource-limited settings.

Methods: During 2023, Thai patients with noninhibitor severe HA or moderate HA with severe bleeding phenotype (historical annualized bleeding rate [ABR] >5 bleeds/year before regular FVIII prophylaxis) who received low-/intermediate-dose FVIII secondary prophylaxis ≥8 months were enrolled.

First-episode mild depression in young adults is a pre-proatherogenic condition even in the absence of subclinical metabolic syndrome: lowered lecithin-cholesterol acyltransferase as a key factor.

Background: Major depression is classified into distinct subtypes: simple (SDMD) and major dysmood disorder (MDMD). MDMD patients exhibit elevated atherogenicity and decreased reverse cholesterol transport (RCT). However, comprehensive data regarding lipid metabolism is absent in first episode (FE)-SDMD.

Demoralization: A concept analysis through a scoping review methodology.

Background: Demoralization is a complex construct comprising of several clinical phenomena that has gained increasing interest in clinical practice and research; however, the concept needs to be sufficiently specified and clearly described. A concept analysis of demoralization is necessary to integrate previous research findings and establish the scientific foundation for future intervention research.

Aim: To analyze the concept of demoralization in terms of its antecedents, attributes, consequences, and empirical referents in health.

The evolutionary history of Plasmodium falciparum from mitochondrial and apicoplast genomes of China-Myanmar border isolates.

Background: The frequent communication between African and Southeast Asian (SEA) countries has led to the risk of imported malaria cases in the China-Myanmar border (CMB) region. Therefore, tracing the origins of new malaria infections is important in the maintenance of malaria-free zones in this border region. A new genotyping tool based on a robust mitochondrial (mt) /apicoplast (apico) barcode was developed to estimate genetic diversity and infer the evolutionary history of Plasmodium falciparum across the major distribution ranges.

Finite element analysis on implant-supported bar with different geometric shapes.

Background: The selection guideline for the implant-supported bar connectors (ISBC) of hybrid denture is lacking. This study investigated the maximum von Mises stress (vMS), stress distribution, and displacement of various geometric ISBC in mandibular hybrid dentures, as well as the maximum principal stress (σmax) in the acrylic resin part, through finite element analysis.

Methods: Four different geometric cross-sectional patterns for mandibular ISBC-L, Y, I, and Square-of equal volume, based on the "All-on-4" concept, were created.

Delayed spontaneous resolution of a double anterior chamber following deep anterior lamellar keratoplasty (DALK).

Background: This study reports a rare case of delayed spontaneous resolution of double anterior chambers (AC) resulting from non-rhegmatogenous Descemet membrane detachment (DMD) after deep anterior lamellar keratoplasty (DALK). Currently, management guidelines for this condition have not been established.

Case Presentation: A 65-year-old woman with lattice corneal dystrophy underwent uncomplicated DALK, during which an unrecognized type 2 big bubble was present.

The implementation of teledentistry training in orthodontic practice: an explanatory sequential mixed-methods study.

Background: Teledentistry has been increasingly used in orthodontic practice. Comprehensive and appropriate trainings should be required to enhance the effective use of teledentistry. However, there is still a lack of adequate teledentistry training in postgraduate orthodontic programs.

Proteomic analysis of the effects of Girdin on Jiaogulan-treated type 2 diabetes patients.

Jiaogulan (Gynostemma pentaphyllum) is a traditional herb with potential antidiabetic properties. This study investigated the underlying mechanisms of these properties by analysing plasma protein profiles in type 2 diabetes patients. A total of 42 participants were divided into three groups, each comprising 14 individuals: healthy controls (N), untreated type 2 diabetes patients (DM), and Jiaogulan-treated type 2 diabetes patients (DMJ).

Conservation Genetics and Breeding using Molecular Genetic Markers in Japanese Quail ().

Background: The Japanese quail () is a small migratory bird whose main habitats are located in East Asia, Russia, China, Japan, Korea, and India. The Japanese quail was first introduced into the Iraqi research sector in the early 1980s. This investigation aimed to identify the genetic divergence between the available genetic lines of the Japanese quail in Iraq as a first step to conducting further conservation and breeding, benefiting from studying the genetic diversity related to productivity, adaptation, and immune susceptibility.

High-Affinity Lectin Ligands Enable the Detection of Pathogenic Biofilms: Implications for Diagnostics and Therapy.

is a critical priority pathogen and causes life-threatening acute and biofilm-associated chronic infections. The choice of suitable treatment for complicated infections requires lengthy culturing for species identification from swabs or an invasive biopsy. To date, no fast, pathogen-specific diagnostic tools for infections are available.

Ancestral Sequence Reconstruction for Designing Biocatalysts and Investigating their Functional Mechanisms.

Biocatalysis has emerged as a green approach for efficient and sustainable production in various industries. In recent decades, numerous advancements in computational and predictive approaches, including ancestral sequence reconstruction (ASR) have sparked a new wave for protein engineers to improve and expand biocatalyst capabilities. ASR is an evolution-based strategy that uses phylogenetic relationships among homologous extant sequences to probabilistically infer the most likely ancestral sequences.

Differences in smoking cessation behaviors and vaping status among adult daily smokers with and without depression, anxiety, and alcohol use: Findings from the 2018 and 2020 International Tobacco Control Four Country Smoking and Vaping (ITC 4CV) Surveys.

This study examined differences in quit attempts, 1-month quit success, and vaping status at follow-up among a cohort of 3709 daily smokers with and without depression, anxiety, and regular alcohol use who participated in both the 2018 and 2020 International Tobacco Control Four Country Smoking and Vaping (ITC 4CV) Surveys. At baseline, a survey with validated screening tools was used to classify respondents as having no, or one or more of the following: 1) depression, 2) anxiety, and 3) regular alcohol use. Multivariable adjusted regression analyses were used to examine whether baseline (2018) self-report conditions were associated with quit attempts; quit success; and vaping status by follow-up (2020).

Assigning (genus ) to Pseudoberkleasmiaceae (Dothideomycetes, Pleosporomycetidae, Pleosporales) and introducing as a novel species.

species are dematiaceous hyphomycetes that are characterised by acropleurogenous, dictyoseptate, campanulate or cheiroid, and brown to dark brown conidia that are composed of several layers of cells radiating from a protuberant basal cell, and mostly seen with appendages arising from the apical cells. The genus was introduced based on morphology to accommodate five of the six species that exhibited holoblastic conidial ontogeny. was referred to as Ascomycota genus as it was challenging to resolve its taxonomic placement based solely on the available morphological data (no DNA sequence data was previously available).

Development of peptone-based serum-free media to support Vero CCL-81 cell proliferation and optimize SARS-CoV2 viral production.

Background: Developing an optimal media for Vero cell lines is crucial as it directly influences cell survival, proliferation, and virus production. The use of serum in cell culture raises safety concerns in biological production. The United States Food and Drug Administration (FDA) and the European Medicines Agency have implemented stricter regulations on the use of animal-derived components in commercial protein manufacturing to ensure patient safety.

Biomarker potential of plasma cell-free DNA for cholangiocarcinoma.

Background: To prevent the development of cholangiocarcinoma, an effective screening opisthorchiasis viverrini and/or differential diagnosis of and the cholangiocarcinoma is crucial needed. The level and quality of cfDNA in plasma are being investigated for their potential role as biomarkers in cholangiocarcinoma.

Methods: The study enrolled 43 healthy controls (N), 36 -infected subjects (OV), and 36 cholangiocarcinoma patients (CCA).

Thermal management of photovoltaic module using affordable organic phase change material combined with nano metal oxide particles enhancer.

Phase change materials (PCMs) have been widely recognized as a highly efficient medium for thermal energy storage. Many studies have identified the low thermal conductivity of PCMs. In the current investigation, the researchers have blended PCM with nanoparticles to enhance its thermal conductivity and electrical efficiency.

Antimicrobial activity and synergistic effect of phage-encoded antimicrobial peptides with colistin and outer membrane permeabilizing agents against .

Background: poses a significant public health threat. Phage-encoded antimicrobial peptides (AMPs) have emerged as promising candidates in the battle against antibiotic-resistant .

Methods: Antimicrobial peptides from the endolysin of bacteriophage were designed from bacteriophage vB_AbaM_PhT2 and vB_AbaAut_ChT04.