7,443 results match your criteria: "Texas Dermatology & Laser Surgery Center[Affiliation]"

Dr. Frederic E. Mohs significantly advanced the treatment of skin cancer with the development of Mohs micrographic surgery (MMS).

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  • The text discusses the importance of forecasting future health issues in the USA for effective planning and public awareness regarding disease and injury burdens.
  • It describes the methodology for predicting life expectancy, cause-specific mortality, and disability-adjusted life-years (DALYs) from 2022 to 2050 using the Global Burden of Diseases framework.
  • The forecasting includes various scenarios to assess the potential impacts of health risks and improvements across the country, focusing on demographic trends and health-related risk factors.
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  • ChatGPT, a chatbot by OpenAI, was evaluated for its ability to diagnose and suggest workups for common dermatologic conditions.
  • The study involved inputting ten clinical vignettes into ChatGPT4 and analyzing its responses by board-certified dermatologists.
  • Overall, ChatGPT4 achieved a 52% accuracy in diagnoses and a 62% correctness in workup suggestions, performing better in recommending workups than in making accurate diagnoses.
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BPDCN: state of the art.

Hematology Am Soc Hematol Educ Program

December 2024

Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX.

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Retention in dermatological clinical trials is critical for ensuring the validity and reliability of study outcomes, yet participant dropout remains a pervasive challenge. In this analysis, the primary aim is to explore the psychological mechanisms underpinning the efficacy of a buddy system in enhancing retention rates in such trials. The buddy system, where participants are paired with peers who have previously participated in similar clinical trials offers mutual support and leverages the principles of social bonding, accountability, and shared experience to foster commitment and reduce attrition.

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  • Recurrent ovarian cancer patients, especially those resistant to platinum treatments, currently have few effective curative options, prompting a phase 2 clinical trial (NCT02853318) that combined pembrolizumab with bevacizumab and oral cyclophosphamide.
  • The trial included 40 patients and showed promising results, with a median progression-free survival of 10.2 months, a 47.5% objective response rate, and 30% of patients achieving stable disease for over a year while maintaining a good quality of life.
  • Comprehensive analysis revealed that increased T and B cell count and specific microbiome patterns correlated with strong clinical responses, suggesting that understanding the immune environment and gut microbiome could enhance future cancer treatment
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Acne is associated with an increased risk of stress fractures: A population-based cohort study.

J Am Acad Dermatol

December 2024

Harvard Medical School, Boston, Massachusetts; Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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Leukemia cutis (LC) is an uncommon cutaneous manifestation of leukemia that involves the leukocytic infiltration of the skin. LC typically presents after a diagnosis of leukemia has been made but may rarely appear before confirmation of the disease. In this report, we describe the case of an 86-year-old male presenting with LC prior to a clear diagnosis of leukemia in the blood.

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  • Autoimmune diseases like systemic lupus erythematosus (SLE) and psoriasis have been linked to a higher risk of atherosclerotic cardiovascular disease (ASCVD), but the impact of cutaneous lupus erythematosus (CLE) on ASCVD risk is uncertain.
  • A study aimed to compare the incidence and prevalence of ASCVD among patients with CLE, SLE, and psoriasis against a control group without these diseases, utilizing data from a large health database.
  • The results showed that individuals with CLE and SLE had significantly higher odds of developing ASCVD compared to the control group, but psoriasis did not show the same increased risk.
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  • Pilomatrix carcinoma (PMC) is a rare and aggressive hair follicle tumor with high recurrence and metastasis risks, often stemming from benign pilomatricoma or arising independently.
  • A study analyzed various surgical treatments for PMC by reviewing 257 articles from major databases, ultimately including 50 relevant studies, highlighting the effectiveness of different surgical methods.
  • The findings revealed that Mohs micrographic surgery (MMS) had no recurrences in 17 treated cases, while surgical excision resulted in a 34.5% recurrence rate, suggesting that MMS is a superior option to minimize recurrence and preserve tissue.
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Procedural treatments for hidradenitis suppurativa.

J Am Acad Dermatol

December 2024

Department of Surgery, Mary Washington Healthcare, Fredericksburg, Virginia.

Procedural treatments for hidradenitis suppurativa play a pivotal role in management of patients with hidradenitis suppurativa when used in combination with medical therapy. Laser, light, and surgical procedures can be used to improve a patient's symptoms and quality of life. Understanding how and when to use these treatments effectively is important for long-term hidradenitis suppurativa management.

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  • A study was conducted to compare the effectiveness and tolerability of a new retinoid, oleyl adapalenate (OA) at 0.5%, against traditional retinol at 0.5% for treating facial photoaging effects like wrinkles and pigmentation.
  • After 12 weeks, OA showed a significantly greater improvement in wrinkle severity (9.45%) compared to retinol (4.11%), and also reduced facial redness and water loss more effectively.
  • Overall, OA was found to be better tolerated than retinol, indicating its potential as a more favorable option in skincare for photoaging.
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  • The UK Biobank contains genotype data for around 500,000 individuals and over 7,000 traits, but many significant relationships are overlooked due to the vast number of tests conducted.
  • This study focuses on 13 skin-related conditions and identifies 447 important genetic variants that are more likely to affect protein functions, along with a higher CADD score, indicating their potential impact.
  • Through further analysis, the researchers not only confirmed existing pathways related to skin cancers but also discovered five new protein-coding variants linked to conditions like lipomas and systemic lupus erythematosus.
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